Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Benjamin R Lichman"'
Autor:
Bonnie C Wintle, Christian R Boehm, Catherine Rhodes, Jennifer C Molloy, Piers Millett, Laura Adam, Rainer Breitling, Rob Carlson, Rocco Casagrande, Malcolm Dando, Robert Doubleday, Eric Drexler, Brett Edwards, Tom Ellis, Nicholas G Evans, Richard Hammond, Jim Haseloff, Linda Kahl, Todd Kuiken, Benjamin R Lichman, Colette A Matthewman, Johnathan A Napier, Seán S ÓhÉigeartaigh, Nicola J Patron, Edward Perello, Philip Shapira, Joyce Tait, Eriko Takano, William J Sutherland
Publikováno v:
eLife, Vol 6 (2017)
Advances in biological engineering are likely to have substantial impacts on global society. To explore these potential impacts we ran a horizon scanning exercise to capture a range of perspectives on the opportunities and risks presented by biologic
Externí odkaz:
https://doaj.org/article/375630ae17554bfda9c8fed83d5403a9
Publikováno v:
Frontiers in Catalysis, Vol 3 (2023)
Deoxypodophyllotoxin synthase (DPS) is a 2-oxoglutarate (2-OG) dependent non-heme iron (II) dioxygenase that catalyzes the stereoselective ring-closing carbon-carbon bond formation of deoxypodophyllotoxin from the aryllignan (−)-yatein. Deoxypodoph
Externí odkaz:
https://doaj.org/article/be0da50c9a2d49b5ba8e7ce72f00f6c1
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
The Pictet-Spengler condensation of β-arylethylamine and carbonyl compounds is an important step in the synthesis of bioactive alkaloids. Here, the authors report a Pictet-Spengler reaction between dopamine and unactivated ketones catalysed by norco
Externí odkaz:
https://doaj.org/article/5064c200fc83450fa59809ac2239395e
Autor:
Mohamed O. Kamileen, Matthew D. DeMars, Benke Hong, Yoko Nakamura, Christian Paetz, Benjamin R. Lichman, Prashant D. Sonawane, Lorenzo Caputi, Sarah E. O’Connor
Publikováno v:
Journal of the American Chemical Society
Nature uses cycloaddition reactions to generate complex natural product scaffolds. Dehydrosecodine is a highly reactive biosynthetic intermediate that undergoes cycloaddition to generate several alkaloid scaffolds that are the precursors to pharmacol
Autor:
Neil K. Garg, Tang, Sarah E. O'Connor, William C. Turner, Francesca M. Ippoliti, Benjamin R. Lichman, Undramaa Bat-Erdene, John M. Billingsley
Publikováno v:
ACS Catal
Here we report the one-pot, cell-free enzymatic synthesis of the plant monoterpene nepetalactol starting from the readily available geraniol. A pair of orthogonal cofactor regeneration systems permitted NAD(+)-dependent geraniol oxidation followed by
Autor:
Néstor J. Hernández Lozada, Benke Hong, Joshua C. Wood, Lorenzo Caputi, Jérôme Basquin, Ling Chuang, Maritta Kunert, Carlos E. Rodríguez López, Chloe Langley, Dongyan Zhao, C. Robin Buell, Benjamin R. Lichman, Sarah E. O’Connor
Publikováno v:
Nature Communications. 13
Autor:
Néstor J. Hernández Lozada, Benke Hong, Joshua C. Wood, Lorenzo Caputi, Jérôme Basquin, Ling Chuang, Maritta Kunert, Carlos E. Rodríguez López, Chloe Langley, Dongyan Zhao, C. Robin Buell, Benjamin R. Lichman, Sarah E. O’Connor
Publikováno v:
Nature Communications
Thousands of natural products are derived from the fused cyclopentane-pyran molecular scaffold nepetalactol. These natural products are used in an enormous range of applications that span the agricultural and medical industries. For example, nepetala
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4b2b971cf51a10d819cab5cb1edbd1
https://hdl.handle.net/21.11116/0000-000A-D771-421.11116/0000-000C-317B-321.11116/0000-000A-CC7B-721.11116/0000-000A-D76B-C
https://hdl.handle.net/21.11116/0000-000A-D771-421.11116/0000-000C-317B-321.11116/0000-000A-CC7B-721.11116/0000-000A-D76B-C
Autor:
Chanchan Liu, Samuel J. Smit, Jingjie Dang, Peina Zhou, Grant T. Godden, Zheng Jiang, Wukun Liu, Licheng Liu, Wei Lin, Jinao Duan, Qinan Wu, Benjamin R. Lichman
Publikováno v:
Molecular plant.
Biosynthetic gene clusters (BGCs) are regions of a genome where genes involved in a biosynthetic pathway are in proximity. The origin and evolution of plant BGCs, and their role in specialised metabolism, remains unclear. We have assembled a chromoso
Autor:
Benjamin R, Lichman
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2505
The complex and bioactive monoterpene indole alkaloids (MIAs) found in Catharanthus roseus and related species are the products of many millions of years of evolution through mutation and natural selection. Ancestral sequence reconstruction (ASR) is
Autor:
Kaouthar Eljounaidi, Barbara Radzikowska, Caragh Whitehead, Susana Conde, William Davis, Adam Dowle, Swen Langer, Tony Larson, William P. Unsworth, Daphne Ezer, Benjamin R. Lichman
Daphniphyllum alkaloids are structurally diverse nitrogen-containing compounds with polycyclic, stereochemically rich carbon skeletons. Understanding how plants biosynthesise these compounds may lead to greater access to allow exploration of bioactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f26908efa12f6829254485b12bf35232
https://doi.org/10.1101/2022.05.25.493403
https://doi.org/10.1101/2022.05.25.493403