Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Benjamin R DiFrancesco"'
Autor:
Roland Pfoh, Adithya S Subramanian, Jingjing Huang, Dustin J Little, Adam Forman, Benjamin R DiFrancesco, Negar Balouchestani-Asli, Elena N Kitova, John S Klassen, Régis Pomès, Mark Nitz, P Lynne Howell
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8, p e1010750 (2022)
The synthesis of exopolysaccharides as biofilm matrix components by pathogens is a crucial factor for chronic infections and antibiotic resistance. Many periplasmic proteins involved in polymer processing and secretion in Gram-negative synthase depen
Externí odkaz:
https://doaj.org/article/a4e5e4ac72e544bdb741f717ccff0750
Autor:
Erum Razvi, Benjamin R. DiFrancesco, Gregory A. Wasney, Zachary A. Morrison, John Tam, Anick Auger, Perrin Baker, Noor Alnabelseya, Jacquelyn D. Rich, Piyanka Sivarajah, Gregory B. Whitfield, Joe J. Harrison, Roman A. Melnyk, Mark Nitz, P. Lynne Howell
Publikováno v:
Microbiology Spectrum.
Present in more than 500 diverse Gram-negative and 900 Gram-positive organisms, the Pel polysaccharide is one of the most phylogenetically widespread biofilm matrix determinants found to date. Partial de- N -acetylation of this α-1,4 linked N -acety
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:5631-5643
The Carbohydrate Esterase family 4 contains virulence factors which modify peptidoglycan and biofilm-related exopolysaccharides. Despite the importance of this family of enzymes, a potent mechanism-based inhibition strategy has yet to emerge. Based o
Autor:
Natalie C. Bamford, Grace Li, Christopher Ing, Howard Robinson, Dustin J. Little, Benjamin R. DiFrancesco, Régis Pomès, P. Lynne Howell, Mark Nitz
Publikováno v:
Proceedings of the National Academy of Sciences. 111:11013-11018
Poly-β-1,6-N-acetyl-D-glucosamine (PNAG) is an exopolysaccharide produced by a wide variety of medically important bacteria. Polyglucosamine subunit B (PgaB) is responsible for the de-N-acetylation of PNAG, a process required for polymer export and
Autor:
Natalie C. Bamford, Sonja Milek, Rajendar Deora, Mark Nitz, Dustin J. Little, P. Lynne Howell, Tridib Ganguly, Benjamin R. DiFrancesco
Publikováno v:
The Journal of biological chemistry. 290(37)
Bordetella pertussis and Bordetella bronchiseptica are the causative agents of whooping cough in humans and a variety of respiratory diseases in animals, respectively. Bordetella species produce an exopolysaccharide, known as the Bordetella polysacch
Autor:
Benjamin R. DiFrancesco, Alison C. Holloway, Denis J. Crankshaw, Alexander J. Nielsen, Nesrin Vurgun, James McNulty, Carla E. Brown, Jerald J. Nair
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(22)
Bioisosteric replacement of cyclic ketone functionality with aryl halides was investigated on a centrally-flexible, five-component 1,2,3-triazole-containing pharmacophore, resulting in enhanced inhibition of aromatase (CYP450 19A1). Structure-activit
Autor:
James McNulty, Nesrin Vurgun, Benjamin R. DiFrancesco, Alison C. Holloway, Denis J. Crankshaw, Jerald J. Nair, Carla E. Brown, Bernice Tsoi
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(1)
The discovery of a novel five-component 1,2,3-triazole-containing pharmacophore that exhibits potent and selective inhibition of aromatase (CYP 450 19A1) is described. All compounds are derived from an initial aldol reaction of a phenylacetate deriva
Autor:
Régis Pomès, Joanna Poloczek, Grace Li, Natalie C. Bamford, Howell Pl, Howard Robinson, Benjamin R. DiFrancesco, Dustin J. Little, Christopher Ing, Mark Nitz
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 70:C464-C464
Bacteria embedded in a self-produced matrix of exopolymeric substances, or biofilm, represent a significant medical problem, as the bacteria are tolerant to antibiotics, protected from the environment, and isolated from the innate immune system. A ke