Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Benjamin R, Saville"'
Autor:
Robert K. Mahar, Anna McGlothlin, Michael Dymock, Todd C. Lee, Roger J. Lewis, Thomas Lumley, Jocelyn Mora, David J. Price, Benjamin R. Saville, Tom Snelling, Rebecca Turner, Steven A. Webb, Joshua S. Davis, Steven Y. C. Tong, Julie A. Marsh, on behalf of the SNAP Global Trial Steering Committee
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is a multifactorial Bayesian adaptive platform trial that aims to improve the way that S. aureus bloodstream infection, a globally common and severe infectious disease, is trea
Externí odkaz:
https://doaj.org/article/f2f571ebfaca4b29a4b8ece1023e07d1
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 3 (2024)
Background The Breakthrough Devices Program of the US Food and Drug Administration has accelerated the development and evaluation of medical devices for patients with heart failure. One such device is the Optimizer Smart System, which the US Food and
Externí odkaz:
https://doaj.org/article/83937a0bf4024a2db19e952bc53277d2
Autor:
Najib Rahman, Andrew Carson-Stevens, Stavros Petrou, Judith Breuer, Paul Little, Melissa Dobson, Kerenza Hood, Jienchi Dorward, May Ee Png, Richard Hobbs, Gail Hayward, Mark Lown, Nigel Hart, Ly-Mee Yu, Nick Francis, Philip Evans, Oliver van Hecke, Julie Allen, Joseph F Standing, Emma Ogburn, Jennifer Davies, Christopher C Butler, Saye Khoo, Andrew Ustianowski, Victoria Harris, Bhautesh Jani, Jane Holmes, Heather Rutter, Oghenekome Gbinigie, Lucy Cureton, Sarah Barrett, Benjamin R Saville, Nicholas P B Thomas, Monique I Andersson, Mahendra Patel, Jonathan Nguyen-Van-Tam, Duncan Richards, Layla Lavallee, David M Lowe, Tracie-Ann Madden, Joe Marion, Jem Chalk, Elizabeth Hadley, Magdalena Benysek, Mona Koshkouei, Maria Coates, Clare Bateman, Ivy Raymundo-Wood
Publikováno v:
BMJ Open, Vol 13, Iss 8 (2023)
Introduction There is an urgent need to determine the safety, effectiveness and cost-effectiveness of novel antiviral treatments for COVID-19 in vaccinated patients in the community at increased risk of morbidity and mortality from COVID-19.Methods a
Externí odkaz:
https://doaj.org/article/f284538c5d9a4aadbf25f6d87d454717
Autor:
Jonathan J. Ratcliff, Alex J. Hall, Edoardo Porto, Benjamin R. Saville, Roger J. Lewis, Jason W. Allen, Michael Frankel, David W. Wright, Daniel L. Barrow, Gustavo Pradilla
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
BackgroundIntracerebral hemorrhage (ICH) is a potentially devastating condition with elevated early mortality rates, poor functional outcomes, and high costs of care. Standard of care involves intensive supportive therapy to prevent secondary injury.
Externí odkaz:
https://doaj.org/article/7180233ab4674518ac68a6f414dc3075
Autor:
Jienchi Dorward, Susan Hopkins, Gail Hayward, Ly-Mee Yu, Oliver van Hecke, Julie Allen, Emma Ogburn, Heather Rutter, Oghenekome Gbinigie, Sharon Tonner, Aleksandra Borek, Philip H Evans, Martin Llewelyn, Benjamin R Saville, Nicholas Berry, Hannah Swayze, David Judge, Jenna Grabey, Nicholas P B Thomas, Monique I Andersson, Mahendra Patel
Publikováno v:
BMJ Open, Vol 11, Iss 6 (2021)
Introduction There is an urgent need to idenfy treatments for COVID-19 that reduce illness duration and hospital admission in those at higher risk of a longer illness course and complications.Methods and analysis The Platform Randomised trial of INte
Externí odkaz:
https://doaj.org/article/6dea15b166554be6bf0060fd090d7225
Autor:
Charlie McLeod, Richard Norman, Edward Litton, Benjamin R. Saville, Steve Webb, Thomas L. Snelling
Publikováno v:
Contemporary Clinical Trials Communications, Vol 16, Iss , Pp - (2019)
The purpose of late phase clinical trials is to generate evidence of sufficient validity and generalisability to be translated into practice and policy to improve health outcomes. It is therefore crucial that the chosen endpoints are meaningful to th
Externí odkaz:
https://doaj.org/article/37109659d6144ffbb65a2e31e792acbd
Publikováno v:
Clinical Trials. 19:490-501
Background Multi-arm platform trials investigate multiple agents simultaneously, typically with staggered entry and exit of experimental treatment arms versus a shared control arm. In such settings, there is considerable debate whether to limit analy
Autor:
Sharon D Yeatts, Lydia D Foster, William G Barsan, Nicholas S Berry, Clifton W Callaway, Roger J Lewis, Benjamin R Saville, Robert Silbergleit, Jeffrey A Kline
Publikováno v:
Clin Trials
Background/Aims Fibrinolytic therapy with tenecteplase has been proposed for patients with pulmonary embolism but the optimal dose is unknown. Higher-than-necessary dosing is likely to cause excess bleeding. We designed an adaptive clinical trial to
Autor:
Andre Schultz, Julie A. Marsh, Benjamin R. Saville, Richard Norman, Peter G. Middleton, Hugh W. Greville, Matthew I. Bellgard, Scott M. Berry, Tom Snelling
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Cystic fibrosis is a genetic disease typically characterized by progressive lung damage and premature mortality. Pulmonary exacerbations, or flare-ups of the lung disease, often require hospitalization for intensive treatment. Approximately 25% of pa
Externí odkaz:
https://doaj.org/article/9a4376be32994aa3ac3fc809dad1f799
Autor:
Christopher C Butler, F D Richard Hobbs, Oghenekome A Gbinigie, Najib M Rahman, Gail Hayward, Duncan B Richards, Jienchi Dorward, David M Lowe, Joseph F Standing, Judith Breuer, Saye Khoo, Stavros Petrou, Kerenza Hood, Jonathan S Nguyen-Van-Tam, Mahendra G Patel, Benjamin R Saville, Joe Marion, Emma Ogburn, Julie Allen, Heather Rutter, Nick Francis, Nicholas P B Thomas, Philip Evans, Melissa Dobson, Tracie-Ann Madden, Jane Holmes, Victoria Harris, May Ee Png, Mark Lown, Oliver van Hecke, Michelle A Detry, Christina T Saunders, Mark Fitzgerald, Nicholas S Berry, Lazaro Mwandigha, Ushma Galal, Sam Mort, Bhautesh D Jani, Nigel D Hart, Haroon Ahmed, Daniel Butler, Micheal McKenna, Jem Chalk, Layla Lavallee, Elizabeth Hadley, Lucy Cureton, Magdalena Benysek, Monique Andersson, Maria Coates, Sarah Barrett, Clare Bateman, Jennifer C Davies, Ivy Raymundo-Wood, Andrew Ustianowski, Andrew Carson-Stevens, Ly-Mee Yu, Paul Little, Akosua A Agyeman, Tanveer Ahmed, Damien Allcock, Adrian Beltran-Martinez, Oluseye E Benedict, Nigel Bird, Laura Brennan, Julianne Brown, Gerard Burns, Mike Butler, Zelda Cheng, Ruth Danson, Nigel de Kare-Silver, Devesh Dhasmana, Jon Dickson, Serge Engamba, Stacey Fisher, Robin Fox, Eve Frost, Richard Gaunt, Sarit Ghosh, Ishtiaq Gilkar, Anna Goodman, Steve Granier, Aleksandra Howell, Iqbal Hussain, Simon Hutchinson, Marie Imlach, Greg Irving, Nicholas Jacobsen, James Kennard, Umar Khan, Kyle Knox, Christopher Krasucki, Tom Law, Rem Lee, Nicola Lester, David Lewis, James Lunn, Claire I. Mackintosh, Mehul Mathukia, Patrick Moore, Seb Morton, Daniel Murphy, Rhiannon Nally, Chinonso Ndukauba, Olufunto Ogundapo, Henry Okeke, Amit Patel, Kavil Patel, Ruth Penfold, Satveer Poonian, Olajide Popoola, Alexander Pora, Vibhore Prasad, Rishabh Prasad, Omair Razzaq, Scot Richardson, Simon Royal, Afsana Safa, Satash Sehdev, Tamsin Sevenoaks, Divya Shah, Aadil Sheikh, Vanessa Short, Baljinder S Sidhu, Ivor Singh, Yusuf Soni, Chris Thalasselis, Pete Wilson, David Wingfield, Michael Wong, Maximillian N J Woodall, Nick Wooding, Sharon Woods, Joanna Yong, Francis Yongblah, Azhar Zafar
Publikováno v:
PANORAMIC Trial Collaborative Group, Butler, C C, Hobbs, F D R, Gbinigie, O A, Rahman, N M, Hayward, G, Richards, D B, Dorward, J, Lowe, D M, Standing, J F, Breuer, J, Khoo, S, Petrou, S, Hood, K, Nguyen-Van-Tam, J S, Patel, M G, Saville, B R, Marion, J, Ogburn, E, Allen, J, Rutter, H, Francis, N, Thomas, N P B, Evans, P, Dobson, M, Madden, T-A, Holmes, J, Harris, V, Png, M E, Lown, M, van Hecke, O, Detry, M A, Saunders, C T, Fitzgerald, M, Berry, N S, Mwandigha, L, Galal, U, Mort, S, Jani, B D, Hart, N D, Ahmed, H, Butler, D, McKenna, M, Chalk, J, Lavallee, L, Hadley, E, Cureton, L, Benysek, M, Andersson, M, Coates, M & Barrett, S 2023, ' Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial ', The Lancet, vol. 401, no. 10373, pp. 281-293 . https://doi.org/10.1016/S0140-6736(22)02597-1
Background The safety, effectiveness, and cost-effectiveness of molnupiravir, an oral antiviral medication for SARS-CoV-2, has not been established in vaccinated patients in the community at increased risk of morbidity and mortality from COVID-19. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6937dbf90341fd2ff687fe41c3d612
https://hdl.handle.net/10023/27412
https://hdl.handle.net/10023/27412