Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Benjamin R, Pryce"'
Autor:
Benjamin R. Pryce, Alexander Oles, Erin E. Talbert, Martin J. Romeo, Silvia Vaena, Sudarshana Sharma, Victoria Spadafora, Lauren Tolliver, David A. Mahvi, Katherine A. Morgan, William P. Lancaster, Eryn Beal, Natlie Koren, Bailey Watts, Morgan Overstreet, Stefano Berto, Suganya Subramanian, Kubra Calisir, Anna Crawford, Brian Neelon, Michael C. Ostrowski, Teresa A. Zimmers, James G. Tidball, David J. Wang, Denis C. Guttridge
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114925- (2024)
Summary: Although cancer cachexia is classically characterized as a systemic inflammatory disorder, emerging evidence indicates that weight loss also associates with local tissue inflammation. We queried the regulation of this inflammation and its ca
Externí odkaz:
https://doaj.org/article/d485e34a70874913a4928068b00e19df
Autor:
Victoria Spadafora, Benjamin R. Pryce, Alexander Oles, Erin E. Talbert, Martin Romeo, Silvia Vaena, Stefano Berto, Michael C. Ostrowski, David J. Wang, Denis C. Guttridge
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-19 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) presents with a high mortality rate. Two important features of PDAC contribute to this poor outcome. The first is metastasis which occurs in ~ 80% of PDAC patients. The second is cachexia, w
Externí odkaz:
https://doaj.org/article/c0dab385199c4f3b81dbc7e59c365feb
Autor:
Cédrik Labrèche, David P. Cook, John Abou-Hamad, Julia Pascoal, Benjamin R. Pryce, Khalid N. Al-Zahrani, Luc A. Sabourin
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-14 (2021)
Abstract Background Breast cancer is a highly heterogeneous disease with multiple drivers and complex regulatory networks. Periostin (Postn) is a matricellular protein involved in a plethora of cancer types and other diseases. Postn has been shown to
Externí odkaz:
https://doaj.org/article/9c9e5ccf6503486ea9f67bb494f2c5be
Autor:
Benjamin R. Pryce, David J. Wang, Teresa A. Zimmers, Michael C. Ostrowski, Denis C. Guttridge
Publikováno v:
Cancer Cell. 41:581-584
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6e52f3b49b8d92c75e0549ec7d389e5
https://doi.org/10.1016/j.ccell.2023.02.007
https://doi.org/10.1016/j.ccell.2023.02.007
Autor:
Jonathan J. Hodgins, David P. Cook, Cédrik Labrèche, Benjamin R. Pryce, Michele Ardolino, John Abou-Hamad, Pascale Robineau-Charette, Luc A. Sabourin, Barbara C. Vanderhyden, Khalid N. Al-Zahrani, Rebecca C. Auer, John C. Bell, Christiano Tanese de Souza
Publikováno v:
Oncogene. 39:4592-4602
HER2 is overexpressed in 20–30% of all breast cancers and is associated with an invasive disease and poor clinical outcome. The Ste20-like kinase (SLK) is activated downstream of HER2/Neu and is required for efficient epithelial-to-mesenchymal tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cc4676984bf021acddb906daf74fe3e
https://doi.org/10.1038/s41388-020-1315-3
https://doi.org/10.1038/s41388-020-1315-3
Autor:
Benjamin R. Pryce, Denis C. Guttridge
Publikováno v:
The Systemic Effects of Advanced Cancer ISBN: 9783031072727
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4de9d01ee86342baf9c820ce556767da
https://doi.org/10.1007/978-3-031-09518-4_7
https://doi.org/10.1007/978-3-031-09518-4_7
Publikováno v:
Journal of Cell Science. 134
Over the past 20 years, the Ste20-like kinase (SLK; also known as STK2) has emerged as a central regulator of cytoskeletal dynamics. Reorganization of the cytoskeleton is necessary for a plethora of biological processes including apoptosis, prolifera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543274980da061af4aad07108071c32e
https://doi.org/10.1242/jcs.258269
https://doi.org/10.1242/jcs.258269
Autor:
Cédrik Labrèche, Jérôme Frenette, Luc A. Sabourin, Benjamin R. Pryce, John Abou-Hamad, Antoine Boulanger-Piette, Dounia Hamoudi, Khalid N. Al-Zahrani, Cindy Balog-Alvarez, Jonathan J. Hodgins, Michele Ardolino, Sabrina Bossé, Joe N. Kornegay
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1868(2)
Duchenne's muscular dystrophy (DMD) is a severe muscle wasting disorder characterized by the loss of dystrophin expression, muscle necrosis, inflammation and fibrosis. Ongoing muscle regeneration is impaired by persistent cytokine stress, further dec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc31a1dfee7cad418cf3c6ffc0a678a5
https://pubmed.ncbi.nlm.nih.gov/33259860
https://pubmed.ncbi.nlm.nih.gov/33259860
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1865:1590-1597
We have previously shown that the Ste20-like kinase SLK interacts directly with the LIM domain-binding protein 1, Ldb1. Ldb1 knock down in murine fibroblasts activates SLK and enhances cell migration. To investigate the effect of Ldb1 deletion in Erb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b396fae2e3d8909e675a31213d6b0dd
https://doi.org/10.1016/j.bbamcr.2018.08.013
https://doi.org/10.1016/j.bbamcr.2018.08.013
Publikováno v:
Oncotarget
Invasion can be stimulated in vitro using the soluble ligand transforming growth factor-β (TGFβ) to induce a process called epithelial-to-mesenchymal transition (EMT) characterized by cell-cell junction breakdown and an invasive phenotype. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e13407f7686e6b1c7ecf8705330290
https://doi.org/10.18632/oncotarget.21928
https://doi.org/10.18632/oncotarget.21928