Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Benjamin P Kleinstiver"'
Autor:
Florian Wünnemann, Thierry Fotsing Tadjo, Mélissa Beaudoin, Simon Lalonde, Ken Sin Lo, Benjamin P Kleinstiver, Guillaume Lettre
Publikováno v:
PLoS Genetics, Vol 19, Iss 3, p e1010680 (2023)
Genome-wide association studies have identified >250 genetic variants associated with coronary artery disease (CAD), but the causal variants, genes and molecular mechanisms remain unknown at most loci. We performed pooled CRISPR screens to test the i
Externí odkaz:
https://doaj.org/article/7b4b43e0998f413aa9650954810b1239
Autor:
Andrea Schmidts, Leah C Marsh, Ambike A Srivastava, Amanda A Bouffard, Angela C Boroughs, Rebecca C Larson, Felipe Bedoya, Bryan D Choi, Stefanie R Bailey, Mark B Leick, Sonika Vatsa, Michael C Kann, Michelle S Prew, Benjamin P Kleinstiver, J Keith Joung
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Adoptive cell therapy with chimeric antigen receptor T cells (CAR-T) has become a standard treatment for patients with certain aggressive B cell malignancies and holds promise to improve the care of patients suffering from numerous other c
Externí odkaz:
https://doaj.org/article/1383b25b9a8e4f49a0640c17e9556951
Autor:
Zachariah L. McLean, Dadi Gao, Kevin Correia, Jennie C. L. Roy, Shota Shibata, Iris N. Farnum, Zoe Valdepenas-Mellor, Marina Kovalenko, Manasa Rapuru, Elisabetta Morini, Jayla Ruliera, Tammy Gillis, Diane Lucente, Benjamin P. Kleinstiver, Jong-Min Lee, Marcy E. MacDonald, Vanessa C. Wheeler, Ricardo Mouro Pinto, James F. Gusella
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Huntington’s disease (HD) is a dominant neurological disorder caused by an expanded HTT exon 1 CAG repeat that lengthens huntingtin’s polyglutamine tract. Lowering mutant huntingtin has been proposed for treating HD, but genetic modifier
Externí odkaz:
https://doaj.org/article/04c90e61e38c4922b3fb3425418eb127
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23804 (2011)
Homing endonucleases are site-specific DNA endonucleases that function as mobile genetic elements by introducing double-strand breaks or nicks at defined locations. Of the major families of homing endonucleases, the modular GIY-YIG endonucleases are
Externí odkaz:
https://doaj.org/article/0af65566a9214451a379eb69ee03264b
Autor:
Kathleen A. Christie, Jimmy A. Guo, Rachel A. Silverstein, Roman M. Doll, Megumu Mabuchi, Hannah E. Stutzman, Jiecong Lin, Linyuan Ma, Russell T. Walton, Luca Pinello, G. Brett Robb, Benjamin P. Kleinstiver
Publikováno v:
Nature Biotechnology. 41:409-416
Autor:
Máté G. Kiss, John E. Mindur, Abi G. Yates, Donghoon Lee, John F. Fullard, Atsushi Anzai, Wolfram C. Poller, Kathleen A. Christie, Yoshiko Iwamoto, Vladimir Roudko, Jeffrey Downey, Christopher T. Chan, Pacific Huynh, Henrike Janssen, Achilles Ntranos, Jan D. Hoffmann, Walter Jacob, Sukanya Goswami, Sumnima Singh, David Leppert, Jens Kuhle, Seunghee Kim-Schulze, Matthias Nahrendorf, Benjamin P. Kleinstiver, Fay Probert, Panos Roussos, Filip K. Swirski, Cameron S. McAlpine
Publikováno v:
Immunity.
Autor:
Lisa Nieland, Thomas S. van Solinge, Pike See Cheah, Liza M. Morsett, Joseph El Khoury, Joseph I. Rissman, Benjamin P. Kleinstiver, Marike L.D. Broekman, Xandra O. Breakefield, Erik R. Abels
Publikováno v:
Molecular Therapy - Oncolytics. 25:121-136
Non-coding RNAs, including microRNAs (miRNAs), support the progression of glioma. miR-21 is a small, non-coding transcript involved in regulating gene expression in multiple cellular pathways, including the regulation of proliferation. High expressio
Autor:
Doo Eun Choi, Jun Wan Shin, Sophia Zeng, Eun Pyo Hong, Jae-Hyun Jang, Jacob M. Loupe, Vanessa C. Wheeler, Hannah E. Stutzman, Benjamin P. Kleinstiver, Jong-Min Lee
Publikováno v:
bioRxiv
An expanded CAG repeat in the huntingtin gene (HTT) causes Huntington’s disease (HD). Since the length of uninterrupted CAG repeat, not polyglutamine, determines the age-at-onset in HD, base editing strategies to convert CAG to CAA are anticipated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95978ca0d623b50e7eb2b21c91a6b50
https://doi.org/10.1101/2023.04.28.538700
https://doi.org/10.1101/2023.04.28.538700
Autor:
Nabeel Bardeesy, Cyril H. Benes, Kevan M. Shokat, J. Keith Joung, Andrew X. Zhu, Cristina R. Ferrone, Lipika Goyal, Yusuke Mizukami, Andrew S. Liss, Aram F. Hezel, Travis B. Sullivan, Kimberly M. Rieger-Christ, Roger L. Jenkins, Mathew J. Garnett, Ultan McDermott, Patricia Greninger, Regina K. Egan, Leah J. Damon, James T. Webber, Rebecca S. Levin, Yasutaka Kato, Lei Shi, Jia-Chi Yeo, Mortada S. Najem, Phuong Vu, Benjamin P. Kleinstiver, John D. Gordan, Supriya K. Saha
Source and cell culture information for cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554f923055f544d58b0d54320212c8e6
https://doi.org/10.1158/2159-8290.22531416
https://doi.org/10.1158/2159-8290.22531416
Autor:
Nabeel Bardeesy, Cyril H. Benes, Kevan M. Shokat, J. Keith Joung, Andrew X. Zhu, Cristina R. Ferrone, Lipika Goyal, Yusuke Mizukami, Andrew S. Liss, Aram F. Hezel, Travis B. Sullivan, Kimberly M. Rieger-Christ, Roger L. Jenkins, Mathew J. Garnett, Ultan McDermott, Patricia Greninger, Regina K. Egan, Leah J. Damon, James T. Webber, Rebecca S. Levin, Yasutaka Kato, Lei Shi, Jia-Chi Yeo, Mortada S. Najem, Phuong Vu, Benjamin P. Kleinstiver, John D. Gordan, Supriya K. Saha
Supplementary Figure S1. IDHm ICC are insensitive to IDH inhibition. Supplementary Figure S2. Similarity matrix for drug response of BTC cell lines. Supplementary Figure S3. Hypersensitivity of ICC cells harboring endogenous IDH mutations to dasatini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3c51a5488a4a22b1bc30c07dfe5f23
https://doi.org/10.1158/2159-8290.22531431.v1
https://doi.org/10.1158/2159-8290.22531431.v1