Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Benjamin P Hurrell"'
Autor:
Yumei Li, Christine Wu, Jiyoung Lee, Qiqi Ning, Juhyeon Lim, Hyungjin Eoh, Sean Wang, Benjamin P Hurrell, Omid Akbari, Jing-Hsiung James Ou
Publikováno v:
PLoS Pathogens, Vol 20, Iss 3, p e1012079 (2024)
Macrophages can undergo M1-like proinflammatory polarization with low oxidative phosphorylation (OXPHOS) and high glycolytic activities or M2-like anti-inflammatory polarization with the opposite metabolic activities. Here we show that M1-like macrop
Externí odkaz:
https://doaj.org/article/f1735b83553344999cb0114097c782db
Autor:
Benjamin P Hurrell, Steffen Schuster, Eva Grün, Manuel Coutaz, Roderick A Williams, Werner Held, Bernard Malissen, Marie Malissen, Shida Yousefi, Hans-Uwe Simon, Andreas J Müller, Fabienne Tacchini-Cottier
Publikováno v:
PLoS Pathogens, Vol 11, Iss 5, p e1004929 (2015)
The protozoan Leishmania mexicana parasite causes chronic non-healing cutaneous lesions in humans and mice with poor parasite control. The mechanisms preventing the development of a protective immune response against this parasite are unclear. Here w
Externí odkaz:
https://doaj.org/article/09af7485d6a547b79a7d0472260b5d08
Autor:
Sarah A C Falcão, Tiffany Weinkopff, Benjamin P Hurrell, Fabiana S Celes, Rebecca P Curvelo, Deboraci B Prates, Aldina Barral, Valeria M Borges, Fabienne Tacchini-Cottier, Camila I de Oliveira
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 3, p e0003601 (2015)
BACKGROUND: Neutrophils are the first line of defense against invading pathogens and are rapidly recruited to the sites of Leishmania inoculation. During Leishmania braziliensis infection, depletion of inflammatory cells significantly increases the p
Externí odkaz:
https://doaj.org/article/46dba151668a4c60b30e8562e9907aec
Autor:
Benjamin P. Hurrell, Doumet Georges Helou, Emily Howard, Jacob D. Painter, Pedram Shafiei-Jahani, Arlene H. Sharpe, Omid Akbari
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Regulatory T (Treg) cells have been implicated in the induction of airway tolerance and amelioration of respiratory duct inflammation. Here the authors show, using PD-L2 deficient mice, that the immune suppression signal from PD-L2 is important for m
Externí odkaz:
https://doaj.org/article/dd4e965ac85f475c9f66e78325872bc5
Autor:
Christine Quach, Lauriane Galle-Treger, Omid Akbari, Emily Howard, Doumet Georges Helou, Richard Lo, Marshall Fung, Benjamin P. Hurrell, Pedram Shafiei-Jahani, Hooman Allayee, Jacob D. Painter
Publikováno v:
Mucosal immunology
Allergic asthma is a chronic inflammatory disorder associated with airway hyperreactivity (AHR) whose global prevalence is increasing at an alarming rate. Group 2 innate lymphoid cells (ILC2s) and T helper 2 (TH2) cells are producers of type 2 cytoki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5676a61ba20b54ca7cf099e39b64f1
https://doi.org/10.1038/s41385-021-00388-5
https://doi.org/10.1038/s41385-021-00388-5
Autor:
Benjamin P. Hurrell, Meng Li, Jacob D. Painter, Pedram Shafiei-Jahani, Yong-Hwee Eddie Loh, Doumet Georges Helou, Omid Akbari, Emily Howard, Lauriane Galle-Treger, Christine Quach
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
The prevalence of asthma and airway hyperreactivity (AHR) is increasing at an alarming rate. Group 2 innate lymphoid cells (ILC2s) are copious producers of type 2 cytokines, which leads to AHR and lung inflammation. Here, we show that mouse ILC2s exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312552aaf8bb384498450cb85b718470
https://doaj.org/article/fea260e6f82a47a287a0d596f7eecfe6
https://doaj.org/article/fea260e6f82a47a287a0d596f7eecfe6
Autor:
Lauriane Galle-Treger, Doumet Georges Helou, Christine Quach, Emily Howard, Benjamin P. Hurrell, German R. Aleman Muench, Pedram Shafiei-Jahani, Jacob D. Painter, Andrea Iorga, Lily Dara, Juliet Emamaullee, Lucy Golden-Mason, Hugo R. Rosen, Pejman Soroosh, Omid Akbari
Publikováno v:
Nature Communications. 13
There has been a global increase in rates of obesity with a parallel epidemic of non-alcoholic fatty liver disease (NAFLD). Autophagy is an essential mechanism involved in the degradation of cellular material and has an important function in the main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32ad603b7ade2357f8f1d572e85ed00c
https://doi.org/10.1038/s41467-022-29174-y
https://doi.org/10.1038/s41467-022-29174-y
Autor:
Doumet Georges Helou, Christine Quach, Marshall Fung, Jacob D. Painter, Benjamin P. Hurrell, Yong-Hwee Eddie Loh, Emily Howard, Pedram Shafiei-Jahani, Pejman Soroosh, Arlene H. Sharpe, Omid Akbari
Publikováno v:
The Journal of allergy and clinical immunology.
Neutrophilic asthma is associated with disease severity and corticosteroid insensitivity. Novel therapies are required to manage this life-threatening asthma phenotype. Programmed cell death protein-1 (PD-1) is a key homeostatic modulator of the immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47aea1149ea79a0b971a25388240053b
https://pubmed.ncbi.nlm.nih.gov/35963455
https://pubmed.ncbi.nlm.nih.gov/35963455
PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity
Autor:
Doumet Georges Helou, Benjamin P. Hurrell, Pejman Soroosh, Emily Howard, Arlene H. Sharpe, Richard Lo, Pedram Shafiei-Jahani, Lauriane Galle-Treger, Omid Akbari, Gavin Lewis, Jacob D. Painter
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Allergic asthma is a leading chronic disease associated with airway hyperreactivity (AHR). Type-2 innate lymphoid cells (ILC2s) are a potent source of T-helper 2 (Th2) cytokines that promote AHR and lung inflammation. As the programmed cell death pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d7d921ff2d2653086f48ffe632f73e
https://doaj.org/article/7aaaa31742d140ac9e011cac9002ea8f
https://doaj.org/article/7aaaa31742d140ac9e011cac9002ea8f
Autor:
Emily Howard, Benjamin P. Hurrell, Doumet Georges Helou, Christine Quach, Jacob D. Painter, Pedram Shafiei-Jahani, Marshall Fung, Parkash S. Gill, Pejman Soroosh, Arlene H. Sharpe, Omid Akbari
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
While pulmonary ILC2s represent one of the major tissue-resident innate lymphoid cell populations at steady state and are key drivers of cytokine secretion in their occupational niche, their role in pulmonary cancer progression remains unclear. As th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0d99aa3fdd81ed558fa9a44825f507
http://europepmc.org/articles/PMC8438316
http://europepmc.org/articles/PMC8438316