Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Benjamin P Flynn"'
Autor:
Benjamin P Flynn, Matthew T Birnie, Yvonne M Kershaw, Audrys G Pauza, Sohyoung Kim, Songjoon Baek, Mark F Rogers, Alex R Paterson, Diana A Stavreva, David Murphy, Gordon L Hager, Stafford L Lightman, Becky L Conway-Campbell
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009737 (2021)
Ultradian glucocorticoid rhythms are highly conserved across mammalian species, however, their functional significance is not yet fully understood. Here we demonstrate that pulsatile corticosterone replacement in adrenalectomised rats induces a dynam
Externí odkaz:
https://doaj.org/article/ebb7253002144d5885d6bce3701f46a0
Autor:
Mitsuhiro Yoshimura, Benjamin P. Flynn, Yvonne M. Kershaw, Zidong Zhao, Yoichi Ueta, Stafford L. Lightman, Becky L. Conway-Campbell
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Here we demonstrate, in rodents, how the timing of feeding behaviour becomes disordered when circulating glucocorticoid rhythms are dissociated from lighting cues; a phenomenon most commonly associated with shift-work and transmeridian trave
Externí odkaz:
https://doaj.org/article/bcadd1670f5c46de9d4df0ba63659c00
Autor:
Matthew T. Birnie, Matthew D. B. Claydon, Oliver Troy, Benjamin P. Flynn, Mitsuhiro Yoshimura, Yvonne M. Kershaw, Zidong Zhao, Rebecca C. R. Demski-Allen, Gareth R. I. Barker, E. Clea Warburton, Zuner A. Bortolotto, Stafford L. Lightman, Becky L. Conway-Campbell
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Disrupted circadian activity is associated with many neuropsychiatric disorders. A major coordinator of circadian biological systems is adrenal glucocorticoid secretion which exhibits a pronounced preawakening peak that regulates metabolic, immune, a
Autor:
Matthew T. Birnie, Matthew D.B. Claydon, Benjamin P. Flynn, Mitsuhiro Yoshimura, Yvonne M. Kershaw, Rebecca C.R. Demski-Allen, Gareth R.I. Barker, E. Clea Warburton, Zuner A. Bortolotto, Stafford L. Lightman, Becky L. Conway-Campbell
Neuropsychiatric disorders such as major depression and schizophrenia are highly prevalent and contribute substantially to disease burden worldwide. Despite this, progress understanding the pathophysiology has remained largely elusive, yet these diso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d6aba9fffa08156304733ee8ebb3d98
https://doi.org/10.1101/2022.07.12.499774
https://doi.org/10.1101/2022.07.12.499774
Autor:
Matthew T. Birnie, Alex Paterson, Diana A. Stavreva, YM Kershaw, Becky L. Conway-Campbell, Audrys G Pauza, Songjoon Baek, David Murphy, Mark F. Rogers, Benjamin P. Flynn, Sohyoung Kim, Gordon L. Hager, Stafford L. Lightman
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009737 (2021)
Flynn, B P, Birnie, M T, Kershaw, Y M, Pauza, A G, Kim, S, Baek, S, Rogers, M F, Paterson, A R, Stavreva, D A, Murphy, D, Hager, G L, Lightman, S L & Conway-Campbell, B L 2021, ' Corticosterone pattern-dependent glucocorticoid receptor binding and transcriptional regulation within the liver ', PLoS Genetics, vol. 17, no. 8, e1009737, pp. e1009737 . https://doi.org/10.1371/journal.pgen.1009737
PLoS Genetics
Flynn, B P, Birnie, M T, Kershaw, Y M, Pauza, A G, Kim, S, Baek, S, Rogers, M F, Paterson, A R, Stavreva, D A, Murphy, D, Hager, G L, Lightman, S L & Conway-Campbell, B L 2021, ' Corticosterone pattern-dependent glucocorticoid receptor binding and transcriptional regulation within the liver ', PLoS Genetics, vol. 17, no. 8, e1009737, pp. e1009737 . https://doi.org/10.1371/journal.pgen.1009737
PLoS Genetics
Ultradian glucocorticoid rhythms are highly conserved across mammalian species, however, their functional significance is not yet fully understood. Here we demonstrate that pulsatile corticosterone replacement in adrenalectomised rats induces a dynam
Publikováno v:
Cell Reports
Summary Glucocorticoids act by binding to the glucocorticoid receptor (GR), which binds to specific motifs within enhancers of target genes to activate transcription. Previous studies have suggested that GRs can promote interactions between gene prom
Autor:
Felicity E. Stubbs, Hai Fang, Stafford L. Lightman, Simon C. Biddie, Matthew T. Birnie, Benjamin P. Flynn, Becky L. Conway-Campbell
Publikováno v:
Endocrine Abstracts.
Autor:
Benjamin P. Flynn
Publikováno v:
Annales d'Endocrinologie. 80:70
Autor:
Benjamin P. Flynn, Diana A. Stavreva, Gordon L. Hager, Sohyoung Kim, Stafford L. Lightman, Matthew T. Birnie, Songjoon Baek, YM Kershaw, Becky L. Conway-Campbell
Publikováno v:
Endocrine Abstracts.
Autor:
Charlotte L, George, Matthew T, Birnie, Benjamin P, Flynn, Yvonne M, Kershaw, Stafford L, Lightman, Becky L, Conway-Campbell
Publikováno v:
Molecular and Cellular Endocrinology
In this paper we report differential decoding of the ultradian corticosterone signal by glucocorticoid target tissues. Pulsatile corticosterone replacement in adrenalectomised rats resulted in different dynamics of Sgk1 mRNA production, with a distin