Data from Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction

Autor: Jing-Ruey Joanna Yeh, Edward Chouchani, Othon Iliopoulos, Andrew M. Intlekofer, Eugene Rhee, Benjamin Olenchock, Kyung Bo Kim, Surendra Punganuru, Michelle L. Kelley, Ana M. Metelo, Yan Liu, Yiyun Zhang, Evanna Mills, Wen Zhou, Iiro Taneli Helenius, Hanumantha Rao Madala

Under conditions of inherent or induced mitochondrial dysfunction, cancer cells manifest overlapping metabolic phenotypes, suggesting that they may be targeted via a common approach. Here, we use multiple oxidative phosphorylation (OXPHOS)–competen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de16a69c1792a4adfa552b1373b28ee
https://doi.org/10.1158/0008-5472.c.6512227.v1

A Cycle of Inflammatory Adipocyte Death and Regeneration in Murine Adipose Tissue

Autor: Akio Monji, Yang Zhang, G.V. Naveen Kumar, Christelle Guillermier, Soomin Kim, Benjamin Olenchock, Matthew L. Steinhauser

Publikováno v: Diabetes

Adipose tissue (AT) expands by a combination of two fundamental cellular mechanisms: hypertrophic growth of existing adipocytes or through generation of new adipocytes, also known as hyperplastic growth. Multiple lines of evidence suggest a limited c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1ca363a48212c3c003b16cb1cb521b9
https://europepmc.org/articles/PMC8893943/

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

Autor: Paul M Ridker, Jean G MacFadyen, Tom Thuren, Brendan M Everett, Peter Libby, Robert J Glynn, Paul Ridker, Alberto Lorenzatti, Henry Krum, John Varigos, Peter Siostrzonek, Peter Sinnaeve, Francisco Fonseca, Jose Nicolau, Nina Gotcheva, Jacques Genest, Huo Yong, Miguel Urina-Triana, Davor Milicic, Renata Cifkova, Riina Vettus, Wolfgang Koenig, Stephan D Anker, Athanasios J Manolis, Fernando Wyss, Tamas Forster, Axel Sigurdsson, Prem Pais, Alessandro Fucili, Hisao Ogawa, Hiroaki Shimokawa, Irina Veze, Birute Petrauskiene, Leon Salvador, John Kastelein, Jan Hein Cornel, Tor Ole Klemsdal, Felix Medina, Andrzej Budaj, Luminita Vida-Simiti, Zhanna Kobalava, Petar Otasevic, Daniel Pella, Mitja Lainscak, Ki-Bae Seung, Patrick Commerford, Mikael Dellborg, Marc Donath, Juey-Jen Hwang, Hakan Kultursay, Marcus Flather, Christie Ballantyne, Seth Bilazarian, William Chang, Cara East, Brendan Everett, Les Forgosh, Robert Glynn, Barry Harris, Monica Ligueros, Erin Bohula, Bindu Charmarthi, Susan Cheng, Sherry Chou, Jacqueline Danik, Graham McMahon, Bradley Maron, MingMing Ning, Benjamin Olenchock, Reena Pande, Todd Perlstein, Aruna Pradhan, Natalia Rost, Aneesh Singhal, Viviany Taqueti, Nancy Wei, Howard Burris, Angela Cioffi, Anne Marie Dalseg, Nilanjan Ghosh, Julie Gralow, Tina Mayer, Hope Rugo, Vance Fowler, Ajit P Limaye, Sara Cosgrove, Donald Levine, Renato Lopes, John Scott, Robert Hilkert, Georgia Tamesby, Carolyn Mickel, Brian Manning, Julian Woelcke, Monique Tan, Sheryl Manfreda, Tom Ponce, Jane Kam, Ravinder Saini, Kehur Banker, Thomas Salko, Panjat Nandy, Ronda Tawfik, Greg O'Neil, Shobha Manne, Pravin Jirvankar, Shankar Lal, Deepak Nema, Jaison Jose, Rory Collins, Kent Bailey, Roger Blumenthal, Helen Colhoun, Bernard Gersh

Publikováno v: Lancet (London, England). 390(10105)

Inflammation in the tumour microenvironment mediated by interleukin 1β is hypothesised to have a major role in cancer invasiveness, progression, and metastases. We did an additional analysis in the Canakinumab Anti-inflammatory Thrombosis Outcomes S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812cc417728b9562fe3fc374d1a8746d
https://pubmed.ncbi.nlm.nih.gov/30370085