Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Benjamin Newcomb"'
Autor:
Helena Lamptey, Benjamin Newcomb, Evelyn Y. Bonney, James O. Aboagye, Peter Puplampu, Vincent J. Ganu, Gloria Ansa, Joseph Oliver-Commey, George B. Kyei
Publikováno v:
AIDS Research and Treatment, Vol 2023 (2023)
Introduction. Antiretroviral therapy (ART) has reduced mortality and improved life expectancy among HIV patients but does not provide a cure. Patients must remain on lifelong medications and deal with drug resistance and side effects. This underscore
Externí odkaz:
https://doaj.org/article/56daff3fbf614c33a8032615b6587523
Autor:
Samia Mohammed, Achraf A. Shamseddine, Benjamin Newcomb, Ronald S. Chavez, Tyler D. Panzner, Allen H. Lee, Daniel Canals, Chioma M. Okeoma, Christopher J. Clarke, Yusuf A. Hannun
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-20 (2021)
Abstract Background Doxorubicin (Dox) is a widely used chemotherapy, but its effectiveness is limited by dose-dependent side effects. Although lower Dox doses reduce this risk, studies have reported higher recurrence of local disease with no improvem
Externí odkaz:
https://doaj.org/article/74aeb82b3aa147e8ab18f595aca938cb
Autor:
Benjamin Newcomb, Cosima Rhein, Izolda Mileva, Rasheed Ahmad, Christopher J. Clarke, Justin Snider, Lina M. Obeid, Yusuf A. Hannun
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 7, Pp 1219-1229 (2018)
Acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to produce the biologically active lipid ceramide. Previous studies have implicated ASM in the induction of the chemokine CCL5 in response to TNF-α however, the lipid mediator of this effect was n
Externí odkaz:
https://doaj.org/article/d929eab6ae61435eaff45ec3e1c7b339
Autor:
Benjamin Newcomb, Kyle Tousignant
Publikováno v:
Steel Construction. 14:236-249
Autor:
Aras N. Mattis, Valerie M. Weaver, Lan Wei, Steve S. Ho, Yusuf A. Hannun, Lorena Pantano, Meghan S. Mooring, Bryan C. Fuchs, Jennifer Y. Chen, Alan C. Mullen, Regina Español-Suñer, Diego dos Santos Ferreira, Dean Yimlamai, Andrew M. Tager, Daniel Canals, Raymond T. Chung, Joe M. Segal, Vikram R. Rao, Amy Yu, Johanna R. Schaub, Mai Sedki, Caroline C. Duwaerts, Sarani Ghoshal, Hsiao-Yen Ma, Nadia M. E. Ayad, Scott M. Turner, Jimmy Kuang-Hsien Hu, Benjamin Newcomb, Megan M. Marlow, Stephanie A. Christenson, Izolda Mileva, Dean Sheppard, Sarah Alsamman
Publikováno v:
Sci Transl Med
Science translational medicine, vol 12, iss 557
Science translational medicine, vol 12, iss 557
Hepatic stellate cells (HSCs) drive hepatic fibrosis. Therapies that inactivate HSCs have clinical potential as antifibrotic agents. We previously identified acid ceramidase (aCDase) as an antifibrotic target. We showed that tricyclic antidepressants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a4b8c3ed8a9921917b7e90c8313188
https://europepmc.org/articles/PMC7976849/
https://europepmc.org/articles/PMC7976849/
Autor:
Cosima Rhein, Benjamin Newcomb, Christopher J. Clarke, Lina M. Obeid, Justin Snider, Izolda Mileva, Rasheed Ahmad, Yusuf A. Hannun
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 7, Pp 1219-1229 (2018)
Acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to produce the biologically active lipid ceramide. Previous studies have implicated ASM in the induction of the chemokine CCL5 in response to TNF-α however, the lipid mediator of this effect was n
Autor:
Alan C. Mullen, Bryan C. Fuchs, Joshua V. Pondick, Irina Bronova, Yusuf A. Hannun, Raymond T. Chung, Chan Zhou, Sarani Ghoshal, Samuel R. York, Nicolas Coant, Evgeny Berdyshev, Jennifer Y. Chen, Cungui Mao, Jae Kyo Yi, Benjamin Newcomb, Daniel L. Motola, Kenneth K. Tanabe
Publikováno v:
Scientific Reports
Activation of hepatic stellate cells (HSCs) in response to injury is a key step in hepatic fibrosis, and is characterized by trans-differentiation of quiescent HSCs to HSC myofibroblasts, which secrete extracellular matrix proteins responsible for th
Autor:
Benjamin Newcomb, Leah J. Siskind, Yusuf A. Hannun, Mohamad Adada, David M. Perry, Patrick Roddy, Bill X. Wu, Kazuyuki Kitatani, Lina M. Obeid
Publikováno v:
Journal of Biological Chemistry. 289:22401-22412
Acid sphingomyelinase (ASM) is one of the key enzymes involved in regulating the metabolism of the bioactive sphingolipid ceramide in the sphingolipid salvage pathway, yet defining signaling pathways by which ASM exerts its effects has proven difficu
Autor:
Gursimran Chandhok, Jos van Pelt, Jef Verbeek, Bruno P. A. Cammue, Benjamin Newcomb, Yusuf A. Hannun, Hartmut Schmidt, David Cassiman, Kim Vriens, Andree Zibert, Karin Thevissen, Pieter Spincemaille
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1843:1207-1215
We previously identified the Arabidopsis thaliana-derived decapeptide OSIP108, which increases tolerance of plants and yeast cells to oxidative stress. As excess copper (Cu) is known to induce oxidative stress and apoptosis, and is characteristic for
Autor:
Benjamin Newcomb, Jason L. Gandy, L. Ashley Cowart, Nabil Matmati, Sarah E. Brice, David J. Montefusco, Yusuf A. Hannun
Publikováno v:
Journal of Biological Chemistry. 287:9280-9289
Targets of bioactive sphingolipids in Saccharomyces cerevisiae were previously identified using microarray experiments focused on sphingolipid-dependent responses to heat stress. One of these heat-induced genes is the serine deamidase/dehydratase Cha