Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Benjamin Neuenswander"'
Autor:
Joanna K. Loh, Sun Young Yoon, Thiwanka B. Samarakoon, Alan Rolfe, Patrick Porubsky, Benjamin Neuenswander, Gerald H. Lushington, Paul R. Hanson
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 1293-1302 (2012)
The efficient synthesis of an 80-member library of unique benzoxathiazocine 1,1-dioxides by a microwave-assisted, intermolecular nucleophilic aromatic substitution (SNAr) diversification pathway is reported. Eight benzofused sultam cores were generat
Externí odkaz:
https://doaj.org/article/f068f8b0072a4d89a1cd7033c4f4328e
Autor:
Carlos C Goller, Mehreen Arshad, James W Noah, Subramaniam Ananthan, Carrie W Evans, N Miranda Nebane, Lynn Rasmussen, Melinda Sosa, Nichole A Tower, E Lucile White, Benjamin Neuenswander, Patrick Porubsky, Brooks E Maki, Steven A Rogers, Frank Schoenen, Patrick C Seed
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e96054 (2014)
Uropathogenic Escherichia coli (UPEC) is the leading cause of community-acquired urinary tract infections (UTIs), with over 100 million UTIs occurring annually throughout the world. Increasing antimicrobial resistance among UPEC limits ambulatory car
Externí odkaz:
https://doaj.org/article/87e084b83fca45db96122f19cf43b049
Autor:
Kara C Evans, Lennel A Camuy-Vélez, Benjamin Neuenswander, Josephine R. Chandler, Saida Benomar, Xiaofei Wang, Ellen B Nasseri
Publikováno v:
The ISME Journal. 12:1263-1272
Many Proteobacteria use quorum sensing to regulate production of public goods, such as antimicrobials and proteases, that are shared among members of a community. Public goods are vulnerable to exploitation by cheaters, such as quorum sensing-defecti
Autor:
Victor W. Day, Bronwyn M. Kivell, Thomas E. Prisinzano, Rachel Saylor Crowley, Andrew Biggerstaff, Benjamin Neuenswander, Kelly F. Paton, Alexander M. Sherwood
Publikováno v:
Journal of Medicinal Chemistry. 60:3866-3878
Previous structure-activity studies on the neoclerodane diterpenoid salvinorin A have demonstrated the importance of the acetoxy functionality on the A-ring in its activity as a kappa opioid receptor agonist. Few studies have focused on understanding
Autor:
Charlotte D. Majerczyk, Blake R. Peterson, Jacqueline J. Deay, Mohammad R. Seyedsayamdost, Benjamin Neuenswander, Jennifer R. Klaus, Todd D. Williams, Kyle Monize, Tiffany Bouddhara, Patricia Martins, Josephine R. Chandler, Wyatt Hursh, Justin T. Douglas, Zhe Gao, Mario Rivera
Publikováno v:
Journal of bacteriology. 200(14)
Burkholderia pseudomallei , the causative agent of melioidosis, encodes almost a dozen predicted polyketide (PK) biosynthetic gene clusters. Many of these are regulated by LuxR-I-type acyl-homoserine (AHL) quorum-sensing systems. One of the PK gene c
Publikováno v:
ACS Combinatorial Science. 15:247-254
The solution-phase parallel synthesis of a diverse 71-member library of multisubstituted cyclic imidates is described. The key intermediates, 3-iodomethylene-containing cyclic imidates, are readily prepared in good to excellent yields by the palladiu
Autor:
Peter J. Bosch, Rachel Saylor Crowley, Aimee Culverhouse, Benjamin Neuenswander, Bronwyn M. Kivell, Amy Ewald, Thomas E. Prisinzano
Publikováno v:
Psychopharmacology. 234(16)
Kappa-opioid receptor (KOPr) agonists have pre-clinical anti-cocaine and analgesic effects. However, side effects including sedation, dysphoria, aversion, anxiety and depression limit their therapeutic development. The unique structure of salvinorin
Autor:
Sudeshna Roy, Thomas D.Y. Chung, Frank J. Schoenen, Benjamin Neuenswander, Paolo Bernardi, Jeffrey Aubé, Michael P Hedrick, Michael Forte, Justina Šileikytė
Persistent opening of the mitochondrial permeability transition pore (PTP), an inner membrane channel, leads to mitochondrial dysfunction and renders the PTP a therapeutic target for a host of life-threatening diseases. Herein, we report our effort t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862eeb825f184726d252e06a6171f816
Autor:
Paul R. Hanson, Alan Rolfe, Joanna K. Loh, Gerald H. Lushington, Benjamin Neuenswander, Thiwanka Bandara Samarakoon, Patrick Porubsky, Sun Young Yoon
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 1293-1302 (2012)
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry
The efficient synthesis of an 80-member library of unique benzoxathiazocine 1,1-dioxides by a microwave-assisted, intermolecular nucleophilic aromatic substitution (SNAr) diversification pathway is reported. Eight benzofused sultam cores were generat
Autor:
Danse Bi, Gerald H. Lushington, Conrad Santini, Salim Javed, Patrick Porubsky, Benjamin Neuenswander, Michael G. Organ, David E. Hill, Qin Zang, Paul R. Hanson, Farman Ullah
Publikováno v:
ACS Combinatorial Science. 14:456-459
The construction of a 96-member library of triazolated 1,2,5-thiadiazepane 1,1-dioxides was performed on a Chemspeed Accelerator (SLT-100) automated parallel synthesis platform, culminating in the successful preparation of 94 out of 96 possible produ