Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Benjamin N. Rocke"'
Autor:
Wanida Ruangsiriluk, Kimberly A. Stevens, Markus Boehm, Benjamin N. Rocke, Paula M. Loria, Julie Jia Li Hawkins, Thomas N. O'Connell, Tim Rolph, Roger B. Ruggeri, Philip A. Carpino, David Hepworth, Bruce A. Maguire, Donna N. Petersen
Publikováno v:
Cell Chemical Biology. 23:1362-1371
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that downregulates low-density lipoprotein (LDL) receptor (LDL-R) levels on the surface of hepatocytes, resulting in decreased clearance of LDL-cholesterol (LDL-C). Phenotypi
Autor:
Tim, Markovic, Philip R D, Murray, Benjamin N, Rocke, Andre, Shavnya, David C, Blakemore, Michael C, Willis
Publikováno v:
Journal of the American Chemical Society. 140(46)
Heterocyclic sulfinates are effective reagents in palladium-catalyzed coupling reactions with aryl and heteroaryl halides, often providing high yields of the targeted biaryl. However, the preparation and purification of complex heterocylic sulfinates
Autor:
Doris Chen, Elizabeth V. Jones, Benjamin N. Rocke, Andrew C. Flick, Stephen W. Wright, John I. Trujillo, Stefan France
Publikováno v:
Tetrahedron. 76:131501
Azomethine ylide [3 + 2]-cycloaddition reactions are among the most powerful and well-studied chemical transformations to construct five-membered nitrogen-containing frameworks. However, cycloadditions of azomethine ylides bearing N-alkoxy substituen
Autor:
Angela Wolford, Heather Eng, Yanwei Zhang, Suvi T. M. Orr, Kay Ahn, Daniel W. Widlicka, Carlin Okerberg, Amit S. Kalgutkar, Yingmei Qi, Samantha N. Spath, Paul D. Bonin, Dilinie P. Fernando, Aaron C. Smith, Tim F. Ryder, Karen Walters, Yan Zhang, David Hepworth, Wenhua Jiao, Joseph S. Warmus, Benjamin N. Rocke, Tristan S. Maurer, Daniel Merritt Bowles, Daniel W. Kung, Scott W. Bagley, Philip A. Carpino, Roger B. Ruggeri, Gang Xing, Leonard Buckbinder, Edward L. Conn, Matthew S. Dowling, Raman Sharma
Publikováno v:
Journal of Medicinal Chemistry. 58:8513-8528
Myeloperoxidase (MPO) is a heme peroxidase that catalyzes the production of hypochlorous acid. Clinical evidence suggests a causal role for MPO in various autoimmune and inflammatory disorders including vasculitis and cardiovascular and Parkinson's d
Publikováno v:
Organic letters. 19(22)
A range of 5- and 6-membered heterocycle-derived sulfinates are shown to be effective nucleophilic coupling partners with aryl chlorides and bromides using Pd(0) catalysis. The use of optimal reaction conditions, specifically incorporating a P(t-Bu)2
Publikováno v:
Chemical Science
Pyridine sulfinates are stable and straightforward to prepare nucleophilic coupling partners for palladium catalyzed cross-coupling reactions with aryl and heteroaryl halides. The scope with respect to the halides coupling partner is considerable, an
Publikováno v:
Organic Letters. 20:3148-3149
Publikováno v:
Synfacts. 11:0593-0595
Publikováno v:
Tetrahedron Letters. 53:5467-5470
While optimizing the synthesis of pharmaceutical building block 3 [ethyl 1-(hydroxymethyl)-1,3-dihydroisobenzofuran-1-carboxylate], we encountered an unusual addition of an aryllithium reagent to the ketone oxygen atom of diethyl ketomalonate. Compou
The last two decades have been a period of tremendous growth in the field of organometallic chemistry. This chapter highlights industrial examples where problems in synthetic organic chemistry were solved using the main group metals, lithium and magn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1f50548c10d378857d8d03fb871c6a1
https://doi.org/10.1039/9781782627913-00001
https://doi.org/10.1039/9781782627913-00001