Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Benjamin N Harwood"'
Autor:
Jamie R Doyle, Benjamin N Harwood, Subrahmanian Tarakkad Krishnaji, Vijay M Krishnamurthy, Wei-En Lin, Jean-Philippe Fortin, Krishna Kumar, Alan S Kopin
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e110502 (2014)
Novel strategies are needed to expedite the generation and optimization of peptide probes targeting G protein-coupled receptors (GPCRs). We have previously shown that membrane tethered ligands (MTLs), recombinant proteins comprised of a membrane anch
Externí odkaz:
https://doaj.org/article/43b89814a6d64eacb23319dd84417b82
Autor:
Gabriel B. Borja, Hongkang Zhang, Benjamin N. Harwood, Jane Jacques, Jennifer Grooms, Romina O. Chantre, Dawei Zhang, Adam Barnett, Christopher A. Werley, Yang Lu, Steven F. Nagle, Owen B. McManus, Graham T. Dempsey
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Optogenetic assays provide a flexible, scalable, and information rich approach to probe compound effects for ion channel drug targets in both heterologous expression systems and associated disease relevant cell types. Despite the potential utility an
Externí odkaz:
https://doaj.org/article/fbccbcbdfa4349c68b6c7eb8e5f3089d
Autor:
Kathleen M. Sicinski, Vittorio Montanari, Venkata S. Raman, Jamie R. Doyle, Benjamin N. Harwood, Yi Chi Song, Micaella P. Fagan, Maribel Rios, David R. Haines, Alan S. Kopin, Martin Beinborn, Krishna Kumar
Publikováno v:
ACS Central Science, Vol 7, Iss 3, Pp 454-466 (2021)
Externí odkaz:
https://doaj.org/article/0801e8218c0d49fab074c95cdbfeee66
Autor:
Alan S. Kopin, Martin Beinborn, Micaella P Fagan, Jamie R. Doyle, David R. Haines, Maribel Rios, Kathleen M Sicinski, Venkata S. Raman, Yi Chi Song, Krishna Kumar, Vittorio Montanari, Benjamin N. Harwood
Publikováno v:
ACS Central Science, Vol 7, Iss 3, Pp 454-466 (2021)
ACS Central Science
ACS Central Science
The gut-derived incretin hormone, glucagon-like peptide-1 (GLP1), plays an important physiological role in attenuating post-prandial blood glucose excursions in part by amplifying pancreatic insulin secretion. Native GLP1 is rapidly degraded by the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a981a6490ffab054d45057568971aa31
https://doaj.org/article/0801e8218c0d49fab074c95cdbfeee66
https://doaj.org/article/0801e8218c0d49fab074c95cdbfeee66
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 360:106-116
The Cys-Cys chemokine receptor 6 (CCR6) is a well-established modulator of inflammation. Although several genetic associations have been identified between CCR6 polymorphisms and immune system disorders (e.g., rheumatoid arthritis and Crohn's disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf226d4f5dbd28e46392a9e3e90fe30
https://doi.org/10.1124/jpet.116.237669
https://doi.org/10.1124/jpet.116.237669
Autor:
Benjamin N. Harwood, Jean-Philippe Fortin, David L. Kaplan, Alan S. Kopin, Balajikarthick Subramanian, Rebecca S. Hayden, Irene Georgakoudi, Kyle P. Quinn
Publikováno v:
Advanced Functional Materials. 24:472-479
The goals of the present study are to establish an in vitro co-culture model of osteoblast and osteoclast function and to quantify the resulting bone remodeling. The bone is tissue engineered using well-defined silk protein biomaterials in 2D and 3D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6244b66ee3c5a73572d15a713f3588c2
https://doi.org/10.1002/adfm.201302210
https://doi.org/10.1002/adfm.201302210
Autor:
Benjamin N. Harwood, Subrahmanian Tarakkad Krishnaji, Jamie R. Doyle, Krishna Kumar, Jean-Philippe Fortin, Alan S. Kopin, Venkata S. Raman
Publikováno v:
The FASEB Journal. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6134a14062c622876adfd047ad6c0028
https://doi.org/10.1096/fasebj.29.1_supplement.1022.1
https://doi.org/10.1096/fasebj.29.1_supplement.1022.1
Publikováno v:
The FASEB Journal. 29
The chemokine receptor subfamily of GPCRs plays a central role in the migration of immune cells. Family member C-C Chemokine Receptor 6 (CCR6) is associated with the trafficking of the pro-inflamma...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbcd089d336de301a0081d55cb4d9591
https://doi.org/10.1096/fasebj.29.1_supplement.772.15
https://doi.org/10.1096/fasebj.29.1_supplement.772.15
Publikováno v:
The Journal of experimental biology. 217(Pt 22)
Bursicon is a hormone that modulates wing expansion, cuticle hardening, and melanization in Drosophila melanogaster. Bursicon activity is mediated through its cognate G protein-coupled receptor, rickets. We have developed a membrane tethered bursicon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30df07032c19eae0c57c46be65af76e1
https://pubmed.ncbi.nlm.nih.gov/25278473
https://pubmed.ncbi.nlm.nih.gov/25278473
Autor:
Ci Chen, Jean-Philippe Fortin, Kevin Gao, Martin Beinborn, Alan S. Kopin, Benjamin N. Harwood
The study of complex heterodimeric peptide ligands has been hampered by a paucity of pharmacological tools. To facilitate such investigations, we have explored the utility of membrane tethered ligands (MTLs). Feasibility of this recombinant approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f887fec17651e3aedb736c391e75c5
https://europepmc.org/articles/PMC3608437/
https://europepmc.org/articles/PMC3608437/
