Propagation of orientation selectivity in a spiking network model of layered primary visual cortex.

Autor: Benjamin Merkt, Friedrich Schüßler, Stefan Rotter

Publikováno v: PLoS Computational Biology, Vol 15, Iss 7, p e1007080 (2019)

Neurons in different layers of sensory cortex generally have different functional properties. But what determines firing rates and tuning properties of neurons in different layers? Orientation selectivity in primary visual cortex (V1) is an interesti

Externí odkaz: https://doaj.org/article/073a1e1f5653464883b71c4372806126

Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds

Autor: Fang Zhang, Sebastian Malkusch, Mike Heilemann, Lea Zimmermann, Franziska Herrmann, Christopher E. Goldring, B. Kevin Park, Robert P. Jones, Angela Oppelt, Daniel Kaschek, Suzanna Huppelschoten, Hassan Malik, Carmen L. Krüger, Benjamin Merkt, Jens Timmer, Ursula Klingmüller, Mara Meub, Amy Schofield, Rowena Sison-Young, Marie Buck-Wiese, Bob van de Water, Marcel Schilling

Publikováno v: npj Systems Biology and Applications
NPJ Systems Biology and Applications
npj Systems Biology and Applications, 4, 23
npj Systems Biology and Applications, Vol 4, Iss 1, Pp 1-16 (2018)

Drug-induced liver injury (DILI) has become a major problem for patients and for clinicians, academics and the pharmaceutical industry. To date, existing hepatotoxicity test systems are only poorly predictive and the underlying mechanisms are still u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de450ad97aa24dfcfaaa163f8f317035
https://doi.org/10.1038/s41540-018-0058-z

Characterization of a Setup to test the Impact of High-Amplitude Pressure Waves on Living Cells

Autor: Johanna Wessolleck, Ulf Dietrich Kahlert, Mischa Schmidt, Jens Osterholz, Martin O. Steinhauser, Jaroslaw Maciaczyk, Donata Maciaczyk, Guido Nikkhah, Benjamin Merkt

Publikováno v: Scientific Reports

The impact of pressure waves on cells may provide several possible applications in biology and medicine including the direct killing of tumors, drug delivery or gene transfection. In this study we characterize the physical properties of mechanical pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e5655e8d458a5da0964853160cfdaa
https://doi.org/10.1038/srep03849