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pro vyhledávání: '"Benjamin Mayro"'
Role of the ABL tyrosine kinases in the epithelial–mesenchymal transition and the metastatic cascade
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-16 (2021)
Abstract The ABL kinases, ABL1 and ABL2, promote tumor progression and metastasis in various solid tumors. Recent reports have shown that ABL kinases have increased expression and/or activity in solid tumors and that ABL inactivation impairs metastas
Externí odkaz:
https://doaj.org/article/be71b935fea0465399abeaf2aea02bf6
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3421-3434.e8 (2019)
Summary: Brain metastases are a common consequence of advanced lung cancer, resulting in cranial neuropathies and increased mortality. Currently, there are no effective therapies to treat brain metastases due to a lack of actionable targets and a fai
Externí odkaz:
https://doaj.org/article/ba2162c3f9b44856a2d706c3b90aa586
Autor:
Benjamin Mayro, Jacob P. Hoj, Christian G. Cerda-Smith, Haley M. Hutchinson, Michael W. Caminear, Hannah L. Thrash, Peter S. Winter, Suzanne E. Wardell, Donald P. McDonnell, Colleen Wu, Kris C. Wood, Ann Marie Pendergast
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The hypoxia-inducible factor 1-α (HIF-1α) enables cells to adapt and respond to hypoxia (Hx), and the activity of this transcription factor is regulated by several oncogenic signals and cellular stressors. While the pathways controlling normoxic de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91c1ed5facafc72acc92a2d4a73e9e59
https://doi.org/10.1073/pnas.2210418120
https://doi.org/10.1073/pnas.2210418120
Autor:
Christopher F. Bassil, Gray R. Anderson, Benjamin Mayro, Kayleigh N. Askin, Peter S. Winter, Samuel Gruber, Tierney M. Hall, Jacob P. Hoj, Christian Cerda-Smith, Haley M. Hutchinson, Shane T. Killarney, Katherine R. Singleton, Li Qin, Kévin Jubien-Girard, Cécile Favreau, Anthony R. Martin, Guillaume Robert, Rachid Benhida, Patrick Auberger, Ann Marie Pendergast, David M. Lonard, Alexandre Puissant, Kris C. Wood
Targeted therapies have revolutionized cancer chemotherapy. Unfortunately, most patients develop multifocal resistance to these drugs within a matter of months. Here, we used a high-throughput phenotypic small molecule screen to identify MCB-613 as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32db380ec124a00fe75c2903a8374419
https://doi.org/10.1101/2023.01.17.524094
https://doi.org/10.1101/2023.01.17.524094
Autor:
Courtney M. McKernan, Aaditya Khatri, Molly Hannigan, Jessica Child, Qiang Chen, Benjamin Mayro, David Snyder, Christopher V. Nicchitta, Ann Marie Pendergast
Publikováno v:
Cell reports. 40(9)
Patients with human epidermal growth factor receptor 2-positive (HER2+/ERBB2) breast cancer often present with brain metastasis. HER2-targeted therapies have not been successful to treat brain metastases in part due to poor blood-brain barrier (BBB)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015077aad4b341cb41df0b48aab41aff
https://pubmed.ncbi.nlm.nih.gov/36044842
https://pubmed.ncbi.nlm.nih.gov/36044842
Role of the ABL tyrosine kinases in the epithelial–mesenchymal transition and the metastatic cascade
Publikováno v:
Cell Communication and Signaling : CCS
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-16 (2021)
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-16 (2021)
The ABL kinases, ABL1 and ABL2, promote tumor progression and metastasis in various solid tumors. Recent reports have shown that ABL kinases have increased expression and/or activity in solid tumors and that ABL inactivation impairs metastasis. The t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84c18a18858a5413098ac45880035b5
https://doi.org/10.1186/s12964-021-00739-6
https://doi.org/10.1186/s12964-021-00739-6
Publikováno v:
Neuro-oncology Advances
Brain metastases are the most common intracranial tumors in adults and are associated with increased patient morbidity and mortality. Limited therapeutic options are currently available for the treatment of brain metastasis. We have identified an act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e98119794c9b3e1918eb26c1eecbbab
https://doi.org/10.1093/noajnl/vdab071.004
https://doi.org/10.1093/noajnl/vdab071.004
Publikováno v:
Cancer Research. 81:PS16-05
Background: RET is an important proto-oncogene involved in the development of various cancers for which we have FDA approved therapies. RET alterations are a known mechanism of resistance against breast cancer systemic therapies and higher RET expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4616d9e3205d3237167078763ceb44aa
https://doi.org/10.1158/1538-7445.sabcs20-ps16-05
https://doi.org/10.1158/1538-7445.sabcs20-ps16-05
Autor:
Benjamin Mayro, Jeremy Force, Carey K. Anders, P. Kelly Marcom, Leylah Drusbosky, Mary Love Taylor, Robin Batchelder
Publikováno v:
Cancer Research. 81:PS16-06
Background: FGFR alterations are a known mechanism of resistance against breast cancer systemic therapies with higher FGFR RNA expression in breast cancer brain metastases compared to their primary tumors. While the genomic characterization of FGFR a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34af6626cd20d4f44e5773eae8c7ebcc
https://doi.org/10.1158/1538-7445.sabcs20-ps16-06
https://doi.org/10.1158/1538-7445.sabcs20-ps16-06
Publikováno v:
Molecular Cancer Research. 18:B25-B25
Despite recent work to uncover the biologic mechanisms governing tumor cell metastasis to the brain, new therapeutic approaches for treating patients with brain-metastatic disease have remained elusive. Through the use of in vivo models of brain meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13319a58c4bb60dc4e5f615a7fe983f2
https://doi.org/10.1158/1557-3125.hippo19-b25
https://doi.org/10.1158/1557-3125.hippo19-b25