Výsledky vyhledávání - "Benjamin Mayes"

Abstract P3-11-13: Synergistic inhibition of MCF-7 mammary gland tumor growth with Piqray® (alpelisib) plus SDX-7320, a novel polymer-conjugated methionine aminopeptidase 2 (MetAP2) inhibitor

Autor: Andrew Slee, James Shanahan, Bradley Carver, Adam Nir, Peter Cornelius, Benjamin Mayes, Sara Little, Nir Raphael

Publikováno v: Cancer Research. 80:P3-11

Mutations in the PI3K pathway have been observed in about 40% of ER+/Her2- breast cancer patients. Amplification as well as mutation of the catalytic p110α subunit of PI3K results in activation of this pathway within tumors, conferring a growth adva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47c8eb04d5dad70aa8785198cca92fac
https://doi.org/10.1158/1538-7445.sabcs19-p3-11-13

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Abstract 1656: Evexomostat: A novel therapeutic in development for the treatment of prostate cancer

Autor: Peter Cornelius, Benjamin Mayes, Bradley J. Carver, James Shanahan, Jennifer Gunter, Colleen Nelson

Publikováno v: Cancer Research. 83:1656-1656

Background: Prostate cancer (PCa) is the second-most diagnosed malignancy among men and is a leading cause of cancer death worldwide (WHO, 2020). Elevated expression of the enzyme methionine aminopeptidase type 2 (MetAP2) in prostate cancer was recen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35af4ab225248ab58108cdd375869c91
https://doi.org/10.1158/1538-7445.am2023-1656

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Abstract P5-05-04: Inhibition of HER2+ tumor growth with SDX-7320, a novel MetAP2 inhibitor, alone and in combination with capivasertib/AZD-5363: Reduced expression of hypoxia-inducible and innate-immune system genes

Autor: Peter Cornelius, Benjamin Mayes, Pierre Dufour, Mark Kalinich, Jonathan Wang, Sara Little, Bradley Carver, James Shanahan

Publikováno v: Cancer Research. 82:P5-05

MetAP2 inhibitors have shown clinical anti-tumor activity, but CNS side effects and poor drug-like properties have generally limited their development. SDX-7320 is a polymer-drug conjugate of a novel fumagillin-derived MetAP2 inhibitor (SDX-7539) att

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3acd3caae394c2610c6df0d9c4996bc4
https://doi.org/10.1158/1538-7445.sabcs21-p5-05-04

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Abstract 1068: SDX-7320, a novel inhibitor of methionine aminopeptidase 2 (MetAP2), inhibits MCF-7 tumor growth in combination with palbociclib (Ibrance®)

Autor: Adam Nir, Benjamin Mayes, Nir Raphael, Bradley Carver, Peter Cornelius, Sara Little, Andrew Slee, Pierre Dufour, James Shanahan

Publikováno v: Cancer Research. 81:1068-1068

Small molecule MetAP2 inhibitor TNP-470 previously showed clinical anti-tumor activity, however CNS side effects and poor drug-like properties limited its development. SDX-7320 is a polymer-drug conjugate of a novel MetAP2 inhibitor (SDX-7539), inten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dedc8be0e478169de40906631fc23fb1
https://doi.org/10.1158/1538-7445.am2021-1068

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Abstract CT153: SDX-7320 elicits improvements in tumor-related and metabolic biomarkers: Results of a phase 1 dose-escalation study in patients with advanced refractory or late-stage solid tumors

Autor: Benjamin Mayes, Alfred Anderson-Villaluz, Alain C. Mita, Kimberly Sullivan, Jasgit C. Sachdev, Neal Salomon, James Shanahan, David Browning, Bradley Carver, Petersen John S, Kris Awerkamp, Johanna C. Bendell, Joe Johnson, Peter Cornelius, Michael S. Gordon, David J. Turnquist, Monica M. Mita

Publikováno v: Cancer Research. 80:CT153-CT153

Background and Rationale: Metabo-oncology is the study of specific tumor types whose growth and/or metastasis is accelerated by metabolic dysfunction, often associated with hyper-adiposity. In this setting the metabolic hormones leptin, adiponectin a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a1e8e2d1da2955570d3dc52fc54412c
https://doi.org/10.1158/1538-7445.am2020-ct153

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Abstract 1226: A novel polymer-conjugated methionine aminopeptidase 2 (MetAP2) inhibitor SDX-7320 inhibits the growth of EO771 mammary gland tumors and ameliorates the immunosuppressive tumor immune micro-environment (TIME)

Autor: Peter Cornelius, James Shanahan, Bradley Carver, Sara Little, David J. Turnquist, Andrew Slee, Benjamin Mayes

Publikováno v: Cancer Research. 79:1226-1226

Obese patients with certain cancers face a greater risk of dying from their cancer compared to non-obese patients. Obesity may contribute to cancer progression via multiple mechanisms: increased leptin, decreased adiponectin, increased adipose tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2d24cfeb04d3e1c74e81291b9ab8ecf
https://doi.org/10.1158/1538-7445.am2019-1226

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Abstract 4919: Preclinical activity of SDX-7320 in mouse models of obesity and obesity-driven cancer

Autor: Andrew Slee, Bradley Carver, Benjamin Mayes, Peter Cornelius, Alfred Anderson-Villaluz, James Shanahan, Robert J. Lutz, Petersen John S, David J. Turnquist, Sara Little, Kimberly Sullivan

Publikováno v: Cancer Research. 78:4919-4919

Cancer patients who are obese face a greater risk of dying from cancer compared to nonobese patients (Calle, 2003). Obesity is believed to contribute to metastasis and progression of cancer via multiple mechanisms: increased secretion of the adipose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d36aa290c5ac9ac7c85694de67f0acb
https://doi.org/10.1158/1538-7445.am2018-4919

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