Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Benjamin M.L. Drum"'
Publikováno v:
Am J Physiol Cell Physiol
Excitation-contraction (EC) coupling is the coordinated process by which an action potential triggers cardiac myocyte contraction. EC coupling is initiated in dyads where the junctional sarcoplasmic reticulum (jSR) is in tight proximity to the sarcol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b396d0b2117c52e20755e2a11f4e90a
https://doi.org/10.1152/ajpcell.00573.2019
https://doi.org/10.1152/ajpcell.00573.2019
Autor:
Haifeng Yin, Jing Li, L. Fernando Santana, Yi Chen, Stephen W. Luckey, Merle L. Gilbert, Xiaoyun Guo, Lei Li, G. Stanley McKnight, John D. Scott, Qinghang Liu, Benjamin M.L. Drum
Publikováno v:
Cardiovascular research, vol 113, iss 2
Li, L; Li, J; Drum, BM; Chen, Y; Yin, H; Guo, X; et al.(2017). Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve. Cardiovascular Research, 113(2), 147-159. doi: 10.1093/cvr/cvw221. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/0912z16q
Li, L; Li, J; Drum, BM; Chen, Y; Yin, H; Guo, X; et al.(2017). Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve. Cardiovascular Research, 113(2), 147-159. doi: 10.1093/cvr/cvw221. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/0912z16q
© 2016 The Author. Aims Impaired Ca2+cycling and myocyte contractility are a hallmark of heart failure triggered by pathological stress such as hemodynamic overload. The A-Kinase anchoring protein AKAP150 has been shown to coordinate key aspects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed411433a7cd22b2f8adb9f95e09c1c8
https://doi.org/10.1093/cvr/cvw221
https://doi.org/10.1093/cvr/cvw221
Publikováno v:
Journal of Molecular and Cellular Cardiology. 66:63-71
Ca(2+) flux through l-type CaV1.2 channels shapes the waveform of the ventricular action potential (AP) and is essential for excitation-contraction (EC) coupling. Timothy syndrome (TS) is a disease caused by a gain-of-function mutation in the CaV1.2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b35e6670c1ddf4071f287a8938e8c2
https://doi.org/10.1016/j.yjmcc.2013.10.021
https://doi.org/10.1016/j.yjmcc.2013.10.021
Publikováno v:
Journal of Molecular and Cellular Cardiology. 81:15-17
The junctional sarcoplasmic reticulum (jSR) is an important and unique ER subdomain in the adult myocyte that concentrates resident proteins to regulate Ca2+ release. To investigate cellular mechanisms for sorting and trafficking proteins to jSR, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e8014afa2c54a18aa13ccae3e182fe
https://doi.org/10.1016/j.yjmcc.2015.01.020
https://doi.org/10.1016/j.yjmcc.2015.01.020
Autor:
Merle L. Gilbert, Haifeng Yin, Benjamin M.L. Drum, Lei Li, Jing Li, G S McKnight, Xiaoyun Guo, Stephen W. Luckey, Yi Chen, Luis Fernando Santana, John D. Scott, Qinghang Liu
Publikováno v:
Circulation Research. 119
Impaired Ca 2+ cycling and myocyte contractility are a hallmark of heart failure triggered by pathological stress such as hemodynamic overload. The A-Kinase anchoring protein AKAP150 has been shown to coordinate key aspects of adrenergic regulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25954645d680731fa341bf80bfbd42ab
https://doi.org/10.1161/res.119.suppl_1.238
https://doi.org/10.1161/res.119.suppl_1.238
Publikováno v:
Drum, BML; Yuan, C; Li, L; Liu, Q; Wordeman, L; & Santana, LF. (2016). Oxidative stress decreases microtubule growth and stability in ventricular myocytes. Journal of Molecular and Cellular Cardiology, 93, 32-43. doi: 10.1016/j.yjmcc.2016.02.012. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/7cj6p7jc
© 2016 Elsevier Ltd. Microtubules (MTs) have many roles in ventricular myocytes, including structural stability, morphological integrity, and protein trafficking. However, despite their functional importance, dynamic MTs had never been visualized in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76fbbde6b3475e00ea82c9d46425a4bc
https://escholarship.org/uc/item/7cj6p7jc
https://escholarship.org/uc/item/7cj6p7jc
Publikováno v:
Biophysical Journal. 110(3)
Microtubules have many roles in non-differentiating cardiomyocytes, including structural stability, morphological integrity, and protein trafficking. However, these proteins had never been visualized. Using adeno-associated viral vectors expressing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1edf6139786af2d64f659f2ebbebe7ac
Publikováno v:
Biophysical Journal. 100:30a
Ether-a-go-go (Eag) family channels, which include hErg1, are voltage-gated K+ channels that are important in cardiac and neural function and have a well-documented role in disease. Eag1 channels in particular are found throughout the central nervous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb482406e60a4ca49c157fd6def7e4ae
https://doi.org/10.1016/j.bpj.2010.12.367
https://doi.org/10.1016/j.bpj.2010.12.367