Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Benjamin M. Partridge"'
Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-13 (2023)
Abstract Background Mycobacterium ulcerans is the causative agent of Buruli ulcer. The pathology of M. ulcerans disease has been attributed to the secretion of a potent macrolide cytotoxin known as mycolactone which plays an important role in the vir
Externí odkaz:
https://doaj.org/article/a6de7d1473ad497ea1fc8987a6c4b384
Publikováno v:
The Journal of Organic Chemistry. 86:9883-9897
We report a Chan-Lam coupling reaction of benzylic and allylic boronic esters with primary and secondary anilines to form valuable alkyl amine products. Both secondary and tertiary boronic esters can be used as coupling partners, with mono-alkylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a696599d7407e631d0126666855b57b
https://doi.org/10.1021/acs.joc.1c00976
https://doi.org/10.1021/acs.joc.1c00976
Autor:
Jennifer C. Louth, Imane Ghafir El Idrissi, James D Grayson, Valerie J. Gillet, Sasha Stimpson, Emma Mead, Antonio de la Vega de León, Margarita Segovia Roldan, Gary Sharman, Claire J. Garwood, Jim A. Thomas, Matthew P. Baumgartner, Amélia P. Rauter, Beining Chen, Samuel J Dawes, Joanna Wolak, Charlotte Dunbar, Ke Ning, Anastasia Zhuravleva, Cleide dos Santos Souza, Benjamin M. Partridge, Nicola Antonio Colabufo, David A. Evans
Publikováno v:
Chemical Science. 12:3768-3785
Amyloid β oligomers (Aβo) are the main toxic species in Alzheimer's disease, which have been targeted for single drug treatment with very little success. In this work we report a new approach for identifying functional Aβo binding compounds. A tai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04daccd30e1189b255839170ec5be975
https://doi.org/10.1039/d0sc04769d
https://doi.org/10.1039/d0sc04769d
Publikováno v:
Advanced Synthesis & Catalysis. 363:2392-2395
Saturated heterocycles are found widely in biologically active compounds such as medicinal drugs and agrochemicals. However, boronic acid‐derived building blocks for these structures have limited availability, particularly in comparison to heteroar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d02a928d824968e891a5bd1ed7f0842f
https://doi.org/10.1002/adsc.202001339
https://doi.org/10.1002/adsc.202001339
Autor:
Benjamin M. Partridge, James D Grayson
Publikováno v:
ACS Catalysis. 9:4296-4301
The oxidation of benzylic boronic esters directly to the ketone is reported. This mild Cu-catalyzed method uses an ambient atmosphere of air as the terminal oxidant and is notably chemoselective. Oxidation of the C-B bond occurs selectively, even in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9139158c8987b095e3a6dfb3daa4375
https://doi.org/10.1021/acscatal.9b00992
https://doi.org/10.1021/acscatal.9b00992
The Cu-catalysed coupling of arylboronic acids with amines, known as the Chan-Lam reaction, is used widely to prepare aryl amines. In contrast, alkyl variants of this reaction, while highly desirable, are underdeveloped. Herein, we report a Chan-Lam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71e8b3f63eb8979fc8dcb9c720fea696
https://doi.org/10.26434/chemrxiv.12925199.v2
https://doi.org/10.26434/chemrxiv.12925199.v2
A nickel catalyst for the allylboration of aldehydes is reported, facilitating the preparation of homoallylic alcohols in high diastereoselectivity. The observed diastereoselectivities and NMR experiments suggest that allylation occurs through a well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbc2664dadb41b714ba8d196d421e60
https://eprints.whiterose.ac.uk/163076/8/BP_Nickel_catalysed_allylboration_revision.pdf
https://eprints.whiterose.ac.uk/163076/8/BP_Nickel_catalysed_allylboration_revision.pdf
Publikováno v:
Angewandte Chemie (International Ed. in English)
A chiral rhodium complex catalyzes the highly enantioselective coupling of arylboronic acids, 1,3‐enynes, and imines to give homoallylic sulfamates. The key step is the generation of allylrhodium(I) species by alkenyl‐to‐allyl 1,4‐rhodium(I)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62a9805bd9985617c5fc04bc56f986f
https://doi.org/10.1002/anie.201709334
https://doi.org/10.1002/anie.201709334
Publikováno v:
Angewandte Chemie. 129:7333-7338
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f9d6ef5e9a3d0784c04e8c273d5f67
https://doi.org/10.1002/ange.201703155
https://doi.org/10.1002/ange.201703155
Autor:
David A. Evans, Benjamin M. Partridge, James H. Grayson, Emma Mead, Claire J. Garwood, Amélia P. Rauter, Teresa Man, Cleide C. Souza, Beining Chen, Imane Ghafir El Idrissi, Ke Ning, Maria Cristina Oliveira, Ana M. Matos, Gary Sharman, Joanna Wolak, Charlotte Dunbar
With no currently available disease-modifying drugs, Alzheimer’s disease is the most common type of dementia affecting over 47 million people worldwide. In light of the most recent discoveries placing the cellular prion protein (PrPC) as a key play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa463a554c9c54853feeb04e0204b91d