Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Benjamin M. Larimer"'
Autor:
Yun Lu, Hailey A. Houson, Carlos A. Gallegos, Alessandro Mascioni, Fang Jia, Argin Aivazian, Patrick N. Song, Shannon E. Lynch, Tiara S. Napier, Ameer Mansur, Benjamin M. Larimer, Suzanne E. Lapi, Ariella B. Hanker, Anna G. Sorace
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-15 (2024)
Abstract Background Immune-positron emission tomography (PET) imaging with tracers that target CD8 and granzyme B has shown promise in predicting the therapeutic response following immune checkpoint blockade (ICB) in immunologically “hot” tumors.
Externí odkaz:
https://doaj.org/article/a67333033d1f4caf9696ae27352ee60a
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 440 (2022)
Advancements in monitoring and predicting of patient-specific response of triple negative breast cancer (TNBC) to immunotherapy (IMT) with and without chemotherapy are needed. Using granzyme B-specific positron emission tomography (GZP-PET) imaging,
Externí odkaz:
https://doaj.org/article/23a8b5afdb5640ce94bd34c245ff13b9
Publikováno v:
Journal of Clinical and Translational Science, Vol 5, Pp 20-20 (2021)
ABSTRACT IMPACT: Insights from this project will provide clinical guidance in treatment of immunotherapy in triple negative breast cancer and identify early imaging biomarkers of treatment response. OBJECTIVES/GOALS: Significant research that address
Externí odkaz:
https://doaj.org/article/d35064a1fd2e4fb3ba1a38a11192ff4f
Autor:
Yun Lu, Meng Li, Adriana V. F. Massicano, Patrick N. Song, Ameer Mansur, Katherine A. Heinzman, Benjamin M. Larimer, Suzanne E. Lapi, Anna G. Sorace
Publikováno v:
Molecules, Vol 26, Iss 6, p 1568 (2021)
Paclitaxel (PTX) treatment efficacy varies in breast cancer, yet the underlying mechanism for variable response remains unclear. This study evaluates whether human epidermal growth factor receptor 2 (HER2) expression level utilizing advanced molecula
Externí odkaz:
https://doaj.org/article/8486229e4f754d789d946344429c7cbc
Autor:
Mohammad O, Sako, Benjamin M, Larimer
Publikováno v:
Journal of Nuclear Medicine. 64:30-33
The adaptive immune response plays a critical role in detecting, eliminating, and creating a memory toward foreign pathogens and malignant cells. Demonstration of the specific and effective target killing of T cells in cancer has reignited interest i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed1b59a7c0c99835e94031931105978
https://doi.org/10.2967/jnumed.122.264097
https://doi.org/10.2967/jnumed.122.264097
Autor:
Benjamin M. Larimer, Anna G. Sorace, Eddy S. Yang, Jianbo Wang, Yufeng Li, Deborah Della Manna, Allyson Angermeier, Patrick N. Song, Kirsten M. Reeves
Purpose:Hypoxia is a common characteristic of many tumor microenvironments, and it has been shown to promote suppression of antitumor immunity. Despite strong biological rationale, longitudinal correlation of hypoxia and response to immunotherapy has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::555c22415eeccbb1d2b089eb89dd570a
https://doi.org/10.1158/1078-0432.c.6531002.v1
https://doi.org/10.1158/1078-0432.c.6531002.v1
Autor:
Umar Mahmood, Genevieve Boland, Eric Wehrenberg-Klee, Emily E. Austin, Sarah Nesti, Emily Bloch, Benjamin M. Larimer
Purpose:The lack of a timely and reliable measure of response to cancer immunotherapy has confounded understanding of mechanisms of resistance and subsequent therapeutic advancement. We hypothesized that PET imaging of granzyme B using a targeted pep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56bcad1029054f3538e783395b9b6203
https://doi.org/10.1158/1078-0432.c.6526670.v1
https://doi.org/10.1158/1078-0432.c.6526670.v1
Autor:
Umar Mahmood, Genevieve Boland, Keith Flaherty, Taylor Kalomeris, Anila Mehta, Frank Dubois, Eric Wehrenberg-Klee, Benjamin M. Larimer
While cancer immunotherapy can produce dramatic responses, only a minority of patients respond to treatment. Reliable response biomarkers are needed to identify responders, and conventional imaging modalities have not proved adequate. Here, we provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e2061a2a086929afb3fb6ab7696536
https://doi.org/10.1158/0008-5472.c.6509415.v1
https://doi.org/10.1158/0008-5472.c.6509415.v1
Autor:
Benjamin M. Larimer, Anna G. Sorace, Eddy S. Yang, Jianbo Wang, Yufeng Li, Deborah Della Manna, Allyson Angermeier, Patrick N. Song, Kirsten M. Reeves
Supplementary Data from 18F-FMISO PET Imaging Identifies Hypoxia and Immunosuppressive Tumor Microenvironments and Guides Targeted Evofosfamide Therapy in Tumors Refractory to PD-1 and CTLA-4 Inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabf3a6c873a11744d51dfe97c62763b
https://doi.org/10.1158/1078-0432.22482809
https://doi.org/10.1158/1078-0432.22482809
Autor:
Umar Mahmood, Genevieve Boland, Eric Wehrenberg-Klee, Emily E. Austin, Sarah Nesti, Emily Bloch, Benjamin M. Larimer
Supplementary Figures and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750a56b06d3421e63ff50e50ab77c459
https://doi.org/10.1158/1078-0432.22467518
https://doi.org/10.1158/1078-0432.22467518