Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Benjamin M. Hogan"'
Autor:
Teodor E. Yordanov, Mikaela S. Keyser, Marco A. Enriquez Martinez, Tyron Esposito, Juliann B. Tefft, Elysse K. Morris, Larisa I. Labzin, Samantha J. Stehbens, Alan E. Rowan, Benjamin M. Hogan, Christopher S. Chen, Jan Lauko, Anne K. Lagendijk
Publikováno v:
APL Bioengineering, Vol 8, Iss 1, Pp 016108-016108-14 (2024)
Cerebral cavernous malformations (CCMs) are vascular lesions that predominantly form in blood vessels of the central nervous system upon loss of the CCM multimeric protein complex. The endothelial cells within CCM lesions are characterized by overact
Externí odkaz:
https://doaj.org/article/a60ddf22761145ba8d3826e7dbcf0896
Autor:
Mei Fong Ng, Juliana Da Silva Viana, Pei Jean Tan, Denver D. Britto, Sy Bing Choi, Sakurako Kobayashi, Norazwana Samat, Dedrick Soon Seng Song, Satoshi Ogawa, Ishwar S. Parhar, Jonathan W. Astin, Benjamin M. Hogan, Vyomesh Patel, Kazuhide S. Okuda
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 108 (2024)
Tumour-associated angiogenesis play key roles in tumour growth and cancer metastasis. Consequently, several anti-angiogenic drugs such as sunitinib and axitinib have been approved for use as anti-cancer therapies. However, the majority of these drugs
Externí odkaz:
https://doaj.org/article/5fb5f72b7457456c83d2000c4f68f22a
Autor:
Josie F. Gibson, Aleksandra Bojarczuk, Robert J. Evans, Alfred Alinafe Kamuyango, Richard Hotham, Anne K. Lagendijk, Benjamin M. Hogan, Philip W. Ingham, Stephen A. Renshaw, Simon A. Johnston
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4 (2022)
Meningitis caused by infectious pathogens is associated with vessel damage and infarct formation, however the physiological cause is often unknown. Cryptococcus neoformans is a human fungal pathogen and causative agent of cryptococcal meningitis, whe
Externí odkaz:
https://doaj.org/article/9a0f3facc19348eb8e32b4c945c9e636
Autor:
Kazuhide S. Okuda, Benjamin M. Hogan
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The formation of the vertebrate vasculature involves the acquisition of endothelial cell identities, sprouting, migration, remodeling and maturation of functional vessel networks. To understand the cellular and molecular processes that drive vascular
Externí odkaz:
https://doaj.org/article/e7de2efacf4347208140fabb69a80296
Autor:
Ilkka Paatero, Loïc Sauteur, Minkyoung Lee, Anne K. Lagendijk, Daniel Heutschi, Cora Wiesner, Camilo Guzmán, Dimitri Bieli, Benjamin M. Hogan, Markus Affolter, Heinz-Georg Belting
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
During the formation of the zebrafish dorsal longitudinal anastomotic vessel, blood vessels connect in a process called anastomosis. Using live imaging, the authors here show that endothelial cell movements during blood vessel anastomosis are associa
Externí odkaz:
https://doaj.org/article/7819155b39d244c7a779701c32e360d4
Autor:
Anne Karine Lagendijk, Guillermo A. Gomez, Sungmin Baek, Daniel Hesselson, William E. Hughes, Scott Paterson, Daniel E. Conway, Heinz-Georg Belting, Markus Affolter, Kelly A. Smith, Martin A. Schwartz, Alpha S. Yap, Benjamin M. Hogan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Mechanical forces play a crucial role during morphogenesis, but how these are sensed and transduced in vivo is not fully understood. Here the authors apply a FRET tension sensor to live zebrafish and study changes in VE-cadherin tension at endothelia
Externí odkaz:
https://doaj.org/article/05f4c034d6774bbe95030ef2e8d3c537
Autor:
Kazuhide S. Okuda, Mei Fong Ng, Nur Faizah Ruslan, Neil I. Bower, Dedrick Soon Seng Song, Huijun Chen, Sungmin Baek, Philip S. Crosier, Katarzyna Koltowska, Jonathan W. Astin, Pei Jean Tan, Benjamin M. Hogan, Vyomesh Patel
Publikováno v:
Pharmaceuticals, Vol 14, Iss 7, p 614 (2021)
Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vasculature, plays critical roles in disease, including in cancer metastasis and chronic inflammation. Preclinical and recent clinical studies have now demonstrated therapeut
Externí odkaz:
https://doaj.org/article/9cccbc0b9d394f71a04ef23b0bbdf222
Autor:
Samuel J. Capon, Gregory J. Baillie, Neil I. Bower, Jason A. da Silva, Scott Paterson, Benjamin M. Hogan, Cas Simons, Kelly A. Smith
Publikováno v:
Biology Open, Vol 6, Iss 1, Pp 125-131 (2017)
The advent of genome editing has significantly altered genetic research, including research using the zebrafish model. To better understand the selectivity of the commonly used CRISPR/Cas9 system, we investigated single base pair mismatches in target
Externí odkaz:
https://doaj.org/article/5b0cc1f36844490db8b27036d76be4c3
Autor:
Adam J. Vogrin, Neil I. Bower, Menachem J. Gunzburg, Sally Roufail, Kazuhide S. Okuda, Scott Paterson, Stephen J. Headey, Steven A. Stacker, Benjamin M. Hogan, Marc G. Achen
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 2023-2036.e4 (2019)
Summary: Lymphatic vascular development establishes embryonic and adult tissue fluid balance and is integral in disease. In diverse vertebrate organs, lymphatic vessels display organotypic function and develop in an organ-specific manner. In all sett
Externí odkaz:
https://doaj.org/article/4ff63854e2ad428099b435bfa53eb1db
Autor:
Katarzyna Koltowska, Anne Karine Lagendijk, Cathy Pichol-Thievend, Johanna C. Fischer, Mathias Francois, Elke A. Ober, Alpha S. Yap, Benjamin M. Hogan
Publikováno v:
Cell Reports, Vol 13, Iss 9, Pp 1828-1841 (2015)
Lymphatic vessels arise chiefly from preexisting embryonic veins. Genetic regulators of lymphatic fate are known, but how dynamic cellular changes contribute during the acquisition of lymphatic identity is not understood. We report the visualization
Externí odkaz:
https://doaj.org/article/0b38814fe9a54367aa6967152f15edac