Výsledky vyhledávání - "Benjamin M Chain"

Akademický článek

Validation of Immune Cell Modules in Multicellular Transcriptomic Data.

Autor: Gabriele Pollara, Matthew J Murray, James M Heather, Rachel Byng-Maddick, Naomi Guppy, Matthew Ellis, Carolin T Turner, Benjamin M Chain, Mahdad Noursadeghi

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0169271 (2017)

Numerous gene signatures, or modules have been described to evaluate the immune cell composition in transcriptomes of multicellular tissue samples. However, significant diversity in module gene content for specific cell types is associated with heter

Externí odkaz: https://doaj.org/article/b6d96bebc5964668a31d80fb86bad66f

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Akademický článek

In Vivo Molecular Dissection of the Effects of HIV-1 in Active Tuberculosis.

Autor: Lucy C K Bell, Gabriele Pollara, Mellissa Pascoe, Gillian S Tomlinson, Rannakoe J Lehloenya, Jennifer Roe, Richard Meldau, Robert F Miller, Alan Ramsay, Benjamin M Chain, Keertan Dheda, Mahdad Noursadeghi

Publikováno v: PLoS Pathogens, Vol 12, Iss 3, p e1005469 (2016)

Increased risk of tuberculosis (TB) associated with HIV-1 infection is primarily attributed to deficient T helper (Th)1 immune responses, but most people with active TB have robust Th1 responses, indicating that these are not sufficient to protect ag

Externí odkaz: https://doaj.org/article/2756ecfddd6448d2884a1415dc005b6c

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Akademický článek

Hybrid spreading mechanisms and T cell activation shape the dynamics of HIV-1 infection.

Autor: Changwang Zhang, Shi Zhou, Elisabetta Groppelli, Pierre Pellegrino, Ian Williams, Persephone Borrow, Benjamin M Chain, Clare Jolly

Publikováno v: PLoS Computational Biology, Vol 11, Iss 4, p e1004179 (2015)

HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient direct cell-to-cell transmission at immune cell contacts. The contribution of this hybrid spread

Externí odkaz: https://doaj.org/article/8e90892e37894ab487cb7972e287ff15

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Akademický článek

Hybrid epidemics--a case study on computer worm conficker.

Autor: Changwang Zhang, Shi Zhou, Benjamin M Chain

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0127478 (2015)

Conficker is a computer worm that erupted on the Internet in 2008. It is unique in combining three different spreading strategies: local probing, neighbourhood probing, and global probing. We propose a mathematical model that combines three modes of

Externí odkaz: https://doaj.org/article/d58be3b454054a14aac6e2c7f22978a6

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Akademický článek

Adherent human alveolar macrophages exhibit a transient pro-inflammatory profile that confounds responses to innate immune stimulation.

Autor: Gillian S Tomlinson, Helen Booth, Sarah J Petit, Elspeth Potton, Greg J Towers, Robert F Miller, Benjamin M Chain, Mahdad Noursadeghi

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e40348 (2012)

Alveolar macrophages (AM) are thought to have a key role in the immunopathogenesis of respiratory diseases. We sought to test the hypothesis that human AM exhibit an anti-inflammatory bias by making genome-wide comparisons with monocyte derived macro

Externí odkaz: https://doaj.org/article/b380b4df59324464b59547e0d832daa7

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Akademický článek

DC priming by M. vaccae inhibits Th2 responses in contrast to specific TLR2 priming and is associated with selective activation of the CREB pathway.

Autor: Nina Le Bert, Benjamin M Chain, Graham Rook, Mahdad Noursadeghi

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e18346 (2011)

The environmental mycobacterium, M. vaccae has been used in mouse models to support the contemporary hygiene hypothesis that non-pathogenic microorganisms reduce allergy associated T helper (Th)2 responses and inflammatory diseases by augmenting regu

Externí odkaz: https://doaj.org/article/7abc4a778bcc478e9c3aa7036cb3329e

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