Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Benjamin M Beckermann"'
Autor:
Claude Négrier, Johnny Mahlangu, Michaela Lehle, Pratima Chowdary, Olivier Catalani, Ronald J Bernardi, Víctor Jiménez-Yuste, Benjamin M Beckermann, Christophe Schmitt, Giuliana Ventriglia, Jerzy Windyga, Roseline d'Oiron, Paul Moorehead, Sunita Koparkar, Vanda Teodoro, Amy D Shapiro, Johannes Oldenburg, Cedric Hermans
Publikováno v:
The Lancet. Haematology, Vol. 10, no.3, p. e168-e177 (2023)
BACKGROUND: Clinical trial data are scarce for the use of prophylaxis in people with non-severe haemophilia A. The HAVEN 6 study aims to assess safety and efficacy of emicizumab prophylaxis in people with non-severe haemophilia A without factor VIII
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5495bafd43f5844c792ca78dc42aa24d
https://hdl.handle.net/2078.1/274140
https://hdl.handle.net/2078.1/274140
Autor:
Rebeca Rodríguez-Veiga, Benjamin M. Beckermann, Annabelle Monnet, Olivier Catalani, Pau Montesinos, Norbert Vey, Andrew H. Wei, Sung-Soo Yoon, Cristina Papayannidis, Christoph Röllig, Katia Gamel, Giovanni Martinelli, Aaron Park, Marina Konopleva, Jordi Esteve, Pierre Fenaux, Christian Recher
Publikováno v:
FUTURE ONCOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Patients with refractory or relapsed acute myeloid leukemia (R/R AML) have a poor prognosis, with a high unmet medical need. Idasanutlin is a small-molecule inhibitor of MDM2, a negative regulator of tumor suppressor p53. By preventing the p53–MDM2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ac6854cc8e2225c8166e0d6e9e9e24
https://doi.org/10.2217/fon-2020-0044
https://doi.org/10.2217/fon-2020-0044
Autor:
Roseline d'Oiron, Anna Kiialainen, Vanda Teodoro, Jerzy Windyga, Johannes Oldenburg, Amy D. Shapiro, Cedric Hermans, Giuliana Ventriglia, Víctor Jiménez-Yuste, Paul Moorehead, Christophe Schmitt, Michaela Lehle, Benjamin M. Beckermann, Olivier Catalani, Claude Negrier, Johnny Mahlangu, Pratima Chowdary
Publikováno v:
Blood. 138:343-343
Background: Emicizumab, a bispecific monoclonal antibody, bridges activated factor (F)IX and FX, substituting for the function of missing activated FVIII in persons with hemophilia A (HA). The HAVEN 6 study (NCT04158648) aims to assess the safety, ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb0cd5ad937007b124c3d8f8c7d7970a
https://doi.org/10.1182/blood-2021-146009
https://doi.org/10.1182/blood-2021-146009
Autor:
Kirsten Mundt, Benjamin M. Beckermann, Nastya Kassir, Christophe Schmitt, Candice Jamois, Magali Genevray, Claire Petry, Joy Yang, Doreen Anders
Publikováno v:
Blood. 136:7-8
Background: Myelosuppression, and especially severe and prolonged neutropenia, can make patients (pts) with acute myeloid leukemia (AML) susceptible to fatal infections. Idasanutlin (idasa), a MDM2 antagonist promoting p53 tumor suppressor activity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa938c970a2e49b713bc568b03cdd296
https://doi.org/10.1182/blood-2020-136419
https://doi.org/10.1182/blood-2020-136419
Autor:
Anja Apel, Markus W. Büchler, Armin Kolb, Peter Schemmer, Thomas Wirth, Gerhard Moldenhauer, Ingrid Herr, Jens Werner, Ariane Groth, Peter Altevogt, Jürgen Mattern, Vanessa Rausch, Alexei V. Salnikov, Bernd Baumann, Georgios Kallifatidis, Benjamin M. Beckermann, Zhanqing Li
Publikováno v:
Gut. 58:949-963
Background and aims: Emerging evidence suggests that highly treatment-resistant tumour-initiating cells (TICs) play a central role in the pathogenesis of pancreatic cancer. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is considere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c411cdecf5fa6f5fad9bbac97ae883f5
https://doi.org/10.1136/gut.2008.149039
https://doi.org/10.1136/gut.2008.149039
Autor:
Georgios Kallifatidis, Rainer Saffrich, D. Frommhold, Ingrid Herr, Ariane Groth, Benjamin M. Beckermann, Alexei V. Salnikov, Helmut Friess, M.W. Büchler, Mario Schubert, Peter Büchler, Jürgen Mattern, N. Giese, Wolfgang Wagner, Anja Apel, Anthony D. Ho, Anke Diehlmann, Gerhard Moldenhauer
Publikováno v:
British Journal of Cancer
Little is known about the factors that enable the mobilisation of human mesenchymal stem cells (MSC) from the bone marrow into the blood stream and their recruitment to and retention in the tumour. We found specific migration of MSC towards growth fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f5442088fdf9017aec3e8873fd1fd9
http://europepmc.org/articles/PMC2527820
http://europepmc.org/articles/PMC2527820
Autor:
Anke Diehlmann, M. Chai, Till Wenger, Rainer Saffrich, Volker Eckstein, M.W. Büchler, Georgios Kallifatidis, Benjamin M. Beckermann, Eduard Ryschich, Mario Schubert, Ingrid Herr, Günther Schütz, Peter Büchler, Anja Apel, Martha-Maria Gebhard, Jürgen Mattern, Anthony D. Ho, Wolfgang Wagner, Ulf Krause, Akmal Khamidjanov, Ariane Groth, Helmut Friess
Publikováno v:
Cancer Gene Therapy. 15:231-240
Genetic modification of human bone marrow mesenchymal stem cells (MSC) is highly valuable for their exploitation in basic science and therapeutic applications, for example in cancer. We present here a new, fast and easy-to-use method to enrich a func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb3831c22e8425293dab3768282882cd
https://doi.org/10.1038/sj.cgt.7701097
https://doi.org/10.1038/sj.cgt.7701097
Autor:
David Cella, Howard A. Burris, Young Hyuck Im, Masakazu Toi, Miguel Martin, Xavier Pivot, Tadeusz Pienkowski, Carlos H. Barrios, Sven Stanzel, Pierfranco Conte, Paul Anthony Ellis, Benjamin M. Beckermann, Wolfgang Eiermann, Jennifer A. Petersen
Publikováno v:
Journal of Clinical Oncology. 34:593-593
593Background: MARIANNE (NCT01120184) is a randomized, phase III study of T-DM1 +/- P vs HT in pts with HER2-positive advanced breast cancer (BC). Methods: Pts with previously treated inoperable lo...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97e8ed714ffe5cb9e7d6d6b01ebfb1e9
https://doi.org/10.1200/jco.2016.34.15_suppl.593
https://doi.org/10.1200/jco.2016.34.15_suppl.593
Autor:
Markus W. Büchler, Ingrid Herr, Eduard Ryschich, Georgios Kallifatidis, Anja Apel, Benjamin M. Beckermann, Ariane Groth, Gerhard Moldenhauer, Alexei V. Salnikov, Akmal Khamidjanov
Publikováno v:
Journal of Cellular and Molecular Medicine
Patients with pancreatic cancer have a poor survival rate, and new therapeutic strategies are needed. Epithelial cell adhesion molecule (EpCAM), suggested as a marker for cancer stem cells, is over-expressed on most pancreatic tumour cells but not on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678c96fcf715113ea61fdd965d846516
https://pubmed.ncbi.nlm.nih.gov/20196789
https://pubmed.ncbi.nlm.nih.gov/20196789
Autor:
Georgios Kallifatidis, Werner Rittgen, Benjamin M. Beckermann, Ingrid Herr, Zheng Liu, C. Zhang, Peter Büchler, Klaus-Michael Debatin, Helmut Friess, Markus W. Büchler, Lutz Edler
Publikováno v:
International Journal of Oncology.
Glucocorticoids (GCs) such as dexamethasone (DEX) have been widely used as co-medication in cancer therapy because they have potent proapoptotic properties in lymphoid cells, can reduce nausea, and alleviate acute toxic effects in healthy tissue. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c48bc70b5263056768ff4b12516e4b1f
https://doi.org/10.3892/ijo.29.5.1295
https://doi.org/10.3892/ijo.29.5.1295