Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Benjamin Liffner"'
Autor:
Jiahong Li, Gerald J. Shami, Benjamin Liffner, Ellie Cho, Filip Braet, Manoj T. Duraisingh, Sabrina Absalon, Matthew W. A. Dixon, Leann Tilley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Plasmodium falciparum is the causative agent of malaria and remains a pathogen of global importance. Asexual blood stage replication, via a process called schizogony, is an important target for the development of new antimalarials. Here we u
Externí odkaz:
https://doaj.org/article/16e0381c3af445ca9a233aecf586db04
Autor:
Benjamin Liffner, Ana Karla Cepeda Diaz, James Blauwkamp, David Anaguano, Sonja Frolich, Vasant Muralidharan, Danny W Wilson, Jeffrey D Dvorin, Sabrina Absalon
Publikováno v:
eLife, Vol 12 (2023)
Apicomplexan parasites exhibit tremendous diversity in much of their fundamental cell biology, but study of these organisms using light microscopy is often hindered by their small size. Ultrastructural expansion microscopy (U-ExM) is a microscopy pre
Externí odkaz:
https://doaj.org/article/63dcb9b405fd4cbf8adabdec1f6400ba
Autor:
Benjamin Liffner, Juan Miguel Balbin, Gerald J. Shami, Ghizal Siddiqui, Jan Strauss, Sonja Frölich, Gary K. Heinemann, Ella May Edwards, Arne Alder, Jan Stephan Wichers, Darren J. Creek, Leann Tilley, Matthew W. A. Dixon, Tim-Wolf Gilberger, Danny W. Wilson
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Benjamin Liffner and Miguel Balbin et al. report that the Plasmodium falciparum protein, PfCERLI2, localises to the cytosolic face of the parasite’s rhoptry bulb and is essential for invasion and growth within human red blood cells.
Externí odkaz:
https://doaj.org/article/70f7a6eab0ab4db184482b483285f76e
Autor:
Jan Stephan Wichers, Paolo Mesén-Ramírez, Gwendolin Fuchs, Jing Yu-Strzelczyk, Jan Stäcker, Heidrun von Thien, Arne Alder, Isabelle Henshall, Benjamin Liffner, Georg Nagel, Christian Löw, Danny Wilson, Tobias Spielmann, Shiqiang Gao, Tim-Wolf Gilberger, Anna Bachmann, Jan Strauss
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Membrane transport proteins perform crucial roles in cell physiology. The obligate intracellular parasite Plasmodium falciparum, an agent of human malaria, relies on membrane transport proteins for the uptake of nutrients from the host, disp
Externí odkaz:
https://doaj.org/article/a379ad10a39b42889f322ee25fa90b4b
Autor:
Amy L. Burns, Brad E. Sleebs, Ghizal Siddiqui, Amanda E. De Paoli, Dovile Anderson, Benjamin Liffner, Richard Harvey, James G. Beeson, Darren J. Creek, Christopher D. Goodman, Geoffrey I. McFadden, Danny W. Wilson
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-23 (2020)
Abstract Background Resistance to front-line antimalarials (artemisinin combination therapies) is spreading, and development of new drug treatment strategies to rapidly kill Plasmodium spp. malaria parasites is urgently needed. Azithromycin is a clin
Externí odkaz:
https://doaj.org/article/e908b3117c7843dcbc36ac8aad95898f
Autor:
Benjamin Liffner, Sonja Frölich, Gary K. Heinemann, Boyin Liu, Stuart A. Ralph, Matthew W. A. Dixon, Tim-Wolf Gilberger, Danny W. Wilson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Rhoptries are essential organelles for invasion of erythrocytes by Plasmodium. Here, the authors characterize the rhoptry-associated protein CERLI1 using quantitative super-resolution microscopy, showing that it is important for parasite invasion and
Externí odkaz:
https://doaj.org/article/70c3ecfb941c4e2fb2554ab17a4f110b
Autor:
Josie Liane Ferreira, Dorothee Heincke, Jan Stephan Wichers, Benjamin Liffner, Danny W. Wilson, Tim-Wolf Gilberger
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2021)
Apicomplexan parasites, such as human malaria parasites, have complex lifecycles encompassing multiple and diverse environmental niches. Invading, replicating, and escaping from different cell types, along with exploiting each intracellular niche, ne
Externí odkaz:
https://doaj.org/article/08a664dcc2eb481c97a16e6d0df9c57b
Autor:
Benjamin Liffner, Sabrina Absalon
Publikováno v:
Microorganisms, Vol 9, Iss 11, p 2306 (2021)
The malaria parasite Plasmodium falciparum undergoes closed mitosis, which occurs within an intact nuclear envelope, and differs significantly from its human host. Mitosis is underpinned by the dynamics of microtubules and the nuclear envelope. To da
Externí odkaz:
https://doaj.org/article/afbc2f8df0064711988723e31d141090
Autor:
J. Stephan Wichers, Judith A. M. Scholz, Jan Strauss, Susanne Witt, Andrés Lill, Laura-Isabell Ehnold, Niklas Neupert, Benjamin Liffner, Renke Lühken, Michaela Petter, Stephan Lorenzen, Danny W. Wilson, Christian Löw, Catherine Lavazec, Iris Bruchhaus, Egbert Tannich, Tim W. Gilberger, Anna Bachmann
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT During its intraerythrocytic development, the malaria parasite Plasmodium falciparum exposes variant surface antigens (VSAs) on infected erythrocytes to establish and maintain an infection. One family of small VSAs is the polymorphic STEVOR
Externí odkaz:
https://doaj.org/article/517410248da74ba7892762b5ae7fb344
Autor:
Jaeson Calla, Nimisha Mittal, Greg LaMonte, Benjamin Liffner, Karla P. Godinez-Macias, Krypton Carolino, Gregory T. Walker, Bing Yu Zou, Emma Paytas, Layné Guerra, Carlos Tong-Rios, Brice Campo, Joseph M. Vinetz, Dionicia Gamboa, Manuela Raffatellu, Sabrina Absalon, Elizabeth A. Winzeler
Changes in host cell morphology and transcription after apicomplexan parasite infection have long been noted, but there have been few studies of the functional consequences of host cell remodeling. Here we show, using time-dependent immunofluorescenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::146eb450ddcd2b932db11551ebb083c6
https://doi.org/10.1101/2022.11.22.517223
https://doi.org/10.1101/2022.11.22.517223