Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Benjamin Lant"'
Autor:
Eric M. Chapman, Benjamin Lant, Yota Ohashi, Bin Yu, Michael Schertzberg, Christopher Go, Deepika Dogra, Janne Koskimäki, Romuald Girard, Yan Li, Andrew G. Fraser, Issam A. Awad, Salim Abdelilah-Seyfried, Anne-Claude Gingras, W. Brent Derry
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Cerebral Cavernous Malformations (CCM) are often caused by mutations in CCM1/KRIT1. Here, Chapman et al. elegantly show that the CCM complex promotes apoptosis by regulating zinc homeostasis and storage via a conserved mechanism that likely generates
Externí odkaz:
https://doaj.org/article/68d7cbe202d44ec59471ae5b3beec946
Autor:
Benjamin Lant, Swati Pal, Eric Michael Chapman, Bin Yu, Daniel Witvliet, Soo Choi, Lisa Zhao, Corinne Albiges-Rizo, Eva Faurobert, W. Brent Derry
Publikováno v:
Cell Reports, Vol 24, Iss 11, Pp 2857-2868.e4 (2018)
Summary: Cerebral cavernous malformations (CCMs) are neurovascular lesions caused by mutations in one of three genes (CCM1–3). Loss of CCM3 causes the poorest prognosis, and little is known about how it regulates vascular integrity. The C. elegans
Externí odkaz:
https://doaj.org/article/7539e9aee8054fa8a03ac92300633579
Publikováno v:
International Journal of Biological Sciences, Vol 6, Iss 1, Pp 9-50 (2010)
Studies of the molecular mechanisms that are involved in stress responses (environmental or physiological) have long been used to make links to disease states in humans. The nematode model organism, Caenorhabditis elegans, undergoes a state of hypome
Externí odkaz:
https://doaj.org/article/7aeb48cf64004148b7c687c6dab522e2
Publikováno v:
Frontiers in Physics, Vol 12 (2024)
We introduce a tensor network algorithm for the solution of p-spin models. We show that bond compression through rank-revealing decompositions performed during the tensor network contraction resolves logical redundancies in the system exactly and is
Externí odkaz:
https://doaj.org/article/808b62cc262c412db233f7fa06b72ca1
Autor:
Jonathan R. Krieger, Bin Yu, Jiefei Tong, Swati Pal, Ruilin Tian, Michael F. Moran, Anne-Claude Gingras, W. Brent Derry, Benjamin Lant
Publikováno v:
Current Biology. 27:868-876
Summary Cerebral cavernous malformations (CCMs) are vascular defects of the CNS that arise from loss of integrity of the endothelial cells lining blood capillaries, causing leakage of blood into the brain [1]. This results in headaches, seizures, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc409850e3739645685d8e718badcde7
https://doi.org/10.1016/j.cub.2017.02.028
https://doi.org/10.1016/j.cub.2017.02.028
Autor:
Issam A. Awad, Andrew G. Fraser, Bin Yu, Yota Ohashi, W. Brent Derry, Yan Li, Romuald Girard, Anne-Claude Gingras, Michael R Schertzberg, Salim Abdelilah-Seyfried, Deepika Dogra, Eric M Chapman, Christopher D. Go, Benjamin Lant, Janne Koskimäki
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Apoptotic death of cells damaged by genotoxic stress requires regulatory input from surrounding tissues. The C. elegans scaffold protein KRI-1, ortholog of mammalian KRIT1/CCM1, permits DNA damage-induced apoptosis of cells in the germline by an unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efae47dc93418b6bee5657bc7cfc4507
http://europepmc.org/articles/PMC6470173
http://europepmc.org/articles/PMC6470173
Autor:
Eva Faurobert, Corinne Albiges-Rizo, W. Brent Derry, Swati Pal, Lisa Zhao, Daniel Witvliet, Soo Hyuk Choi, Benjamin Lant, Bin Yu, Eric M Chapman
Publikováno v:
Cell Reports
Cell Reports, Elsevier Inc, 2018, 24 (11), pp.2857-2868.e4. ⟨10.1016/j.celrep.2018.08.039⟩
Cell Reports, Vol 24, Iss 11, Pp 2857-2868.e4 (2018)
Cell Reports, Elsevier Inc, 2018, 24 (11), pp.2857-2868.e4. ⟨10.1016/j.celrep.2018.08.039⟩
Cell Reports, Vol 24, Iss 11, Pp 2857-2868.e4 (2018)
Summary: Cerebral cavernous malformations (CCMs) are neurovascular lesions caused by mutations in one of three genes (CCM1–3). Loss of CCM3 causes the poorest prognosis, and little is known about how it regulates vascular integrity. The C. elegans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2e94e821a563e0529fe6cddc215b80
https://hal.archives-ouvertes.fr/hal-02354266/document
https://hal.archives-ouvertes.fr/hal-02354266/document
Publikováno v:
SSRN Electronic Journal.
Mechanisms that control biological tube development and integrity are conserved from C. elegans to human, and defects in these processes cause a variety of diseases. Cerebral cavernous malformations (CCM) are neurovascular lesions caused by inactivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a77370b193e7f774243703bb76a06e89
https://doi.org/10.2139/ssrn.3155876
https://doi.org/10.2139/ssrn.3155876
Autor:
Benjamin Lant, W. Brent Derry
Publikováno v:
Cold Spring Harbor protocols. 2014(5)
The transparency of Caenorhabditis elegans makes it an ideal organism for visualizing proteins by immunofluorescence microscopy; however, the tough cuticle of worms and the egg shell surrounding embryos pose challenges in achieving effective fixation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e4aaf37710b396ff601f48d5049ab3
https://pubmed.ncbi.nlm.nih.gov/24786502
https://pubmed.ncbi.nlm.nih.gov/24786502