Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Benjamin L.L. Clayton"'
Autor:
Matthew S. Elitt, H. Elizabeth Shick, Mayur Madhavan, Kevin C. Allan, Benjamin L.L. Clayton, Chen Weng, Tyler E. Miller, Daniel C. Factor, Lilianne Barbar, Baraa S. Nawash, Zachary S. Nevin, Angela M. Lager, Yan Li, Fulai Jin, Drew J. Adams, Paul J. Tesar
Publikováno v:
Stem Cell Reports, Vol 11, Iss 3, Pp 711-726 (2018)
Summary: Pelizaeus-Merzbacher disease (PMD) is a fatal X-linked disorder caused by loss of myelinating oligodendrocytes and consequent hypomyelination. The underlying cellular and molecular dysfunctions are not fully defined, but therapeutic enhancem
Externí odkaz:
https://doaj.org/article/85ceab688bb44f7d8336a4d35cb11973
Autor:
Erin F. Cohn, Benjamin L.L. Clayton, Mayur Madhavan, Sara Yacoub, Yuriy Federov, Katie Paul-Friedman, Timothy J. Shafer, Paul J. Tesar
Publikováno v:
bioRxiv
Exposure to environmental chemicals can impair neurodevelopment1–4. Oligodendrocytes that wrap around axons to boost neurotransmission may be particularly vulnerable to chemical toxicity as they develop throughout fetal development and into adultho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64e8fc17dd38c4cfb424f9da076e392
https://doi.org/10.1101/2023.02.10.528042
https://doi.org/10.1101/2023.02.10.528042
Autor:
Benjamin L.L. Clayton, Paul J. Tesar
Publikováno v:
Curr Opin Cell Biol
Differentiation of oligodendrocyte progenitor cells (OPCs) into myelination-capable mature oligodendrocytes is essential for proper function of the central nervous system. OPCs are tissue-resident stem cells that populate all regions of the central n
Autor:
Kevin C. Allan, Tyler E. Miller, Andrew R. Morton, Marissa A. Scavuzzo, Matthew S. Elitt, Benjamin L.L. Clayton, Lucille R. Hu, Jost K. Vrabic, Hannah E. Olsen, Daniel C. Factor, Jonathan E. Henninger, Richard A. Young, Charles Y. Lin, Peter C. Scacheri, Paul J. Tesar
SUMMARYPluripotent stem cells (PSCs) provide an unlimited source for generating somatic cell types. However, generating fully mature cells constitutes a bottleneck for realizing their full potential in research and medicine. Here, we report a transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ee17af1d86d3aea0ee785bea3821dc2
https://doi.org/10.1101/2022.11.17.516981
https://doi.org/10.1101/2022.11.17.516981
Autor:
Benjamin L.L. Clayton, James D. Kristell, Kevin C. Allan, Molly Karl, Eric Garrison, Yuka Maeno-Hikichi, Annalise M. Sturno, H. Elizabeth Shick, Robert H. Miller, Paul J. Tesar
Disease, injury, and aging induce reactive astrocyte states with pathological functions1-4. In neurodegenerative diseases, inflammatory reactive astrocytes are abundant and contribute to progressive cell loss. Modulating the state or function of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97744fa0614581a8d33f39edd03eb9a9
https://doi.org/10.1101/2021.11.03.467083
https://doi.org/10.1101/2021.11.03.467083
Autor:
Kenneth Earl Sakaie, Jeffrey A. Cohen, Yanming Wang, Paul J. Tesar, Jenny Feng, Se-Hong Oh, Laura E. Baldassari, Benjamin L.L. Clayton
Publikováno v:
Expert Review of Neurotherapeutics. 19:997-1013
Introduction: Approved disease-modifying therapies for multiple sclerosis (MS) lessen inflammatory disease activity that causes relapses and MRI lesions. However, chronic inflammation and demyelination lead to axonal degeneration and neuronal loss, f
Autor:
Ilya Bederman, Benjamin L.L. Clayton, Erin F. Cohn, Marissa A. Scavuzzo, Mayur Madhavan, Artur S. Gevorgyan, Lucille R. Hu, Kevin C. Allan, Paul J. Tesar, Andrew R. Morton, Stevephen Hung, Cynthia F. Bartels
Publikováno v:
Cell Stem Cell
Mammalian cells respond to insufficient oxygen through transcriptional regulators called hypoxia-inducible factors (HIFs). Although transiently protective, prolonged HIF activity drives distinct pathological responses in different tissues. Using a mo
Autor:
Alexej Abyzov, Kevin Cameron Allan, Anahita Amiri, Heather M. Brown, Anne L. Calof, Qiang Chang, Kimberly M. Christian, Benjamin L.L. Clayton, Francesca Cucinotta, Alissa M. D'Gama, Mathew Sean Elitt, L. Fernandez, R. Holly Fitch, Jeffrey A. Golden, Laura Groves, R.J. Hagerman, Eric Jaffe, B.L. Johnson-Kerner, Alexandre Jourdon, Arthur D. Lander, M.J. Leigh, Youngshin Lim, A.H. Mahnke, Jessica Mariani, Guo-li Ming, R.C. Miranda, S.M. Mooney, Jeffrey L. Neul, Zachary Scott Nevin, Lee Niswander, Christopher Oliver, Antonio M. Persico, Sofia A. Pezoa, Christina Pyrgaki, Lawrence T. Reiter, Arianna Ricciardello, Edward Rubenstein, Mustafa Sahin, Rosaysela Santos, Soraya Scuderi, E.H. Sherr, Hongjun Song, Siddharth Srivastava, Paul J. Tesar, Laura Turriziani, Flora M. Vaccarino, Christopher A. Walsh, Feinan Wu, Eunice Y. Yuen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::647b4f4ae80f0afd2ea6367a538313df
https://doi.org/10.1016/b978-0-12-814409-1.01002-8
https://doi.org/10.1016/b978-0-12-814409-1.01002-8
Glia are increasingly appreciated for the varied and critical roles they play in the health and disease of the nervous system. Damage or dysfunction of myelinating glia, oligodendrocytes in the central nervous system and Schwann cells in the peripher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a884394b2a7d2a5c21fee084d7ea7c42
https://doi.org/10.1016/b978-0-12-814409-1.00013-6
https://doi.org/10.1016/b978-0-12-814409-1.00013-6
Autor:
Yan Li, Matthew S. Elitt, Zachary S. Nevin, Paul J. Tesar, Angela M. Lager, H. Elizabeth Shick, Chen Weng, Drew J. Adams, Mayur Madhavan, Tyler E. Miller, Kevin C. Allan, Lilianne Barbar, Fulai Jin, Daniel C. Factor, Baraa S. Nawash, Benjamin L.L. Clayton
Publikováno v:
Stem Cell Reports, Vol 11, Iss 3, Pp 711-726 (2018)
Summary: Pelizaeus-Merzbacher disease (PMD) is a fatal X-linked disorder caused by loss of myelinating oligodendrocytes and consequent hypomyelination. The underlying cellular and molecular dysfunctions are not fully defined, but therapeutic enhancem