Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Benjamin L. Barthel"'
Autor:
Benjamin L. Barthel, Kazunori Nosaka, Min Jyue Huang, Trevor C. Chen, Alan J. Russell, Kuo-Wei Tseng, Hung Wen Liu, Tai Yi Chou
Publikováno v:
Journal of Science and Medicine in Sport. 23:776-781
It has been reported that plasma fast skeletal muscle troponin I (fsTnI) but not slow skeletal muscle troponin I (ssTnI) increases after a bout of eccentric exercise of the elbow flexors. The present study compared the first and second bouts of whole
Autor:
Dan Cox, Eric P. Hoffman, Alan J Russell, Michael Ziemba, Benjamin L. Barthel, Volker Straub, Marissa L Barbieri
Publikováno v:
Musclenerve. 64(1)
INTRODUCTION One of the hallmarks of injured skeletal muscle is the appearance of elevated skeletal muscle proteins in circulation. Human skeletal muscle generally consists of a mosaic of slow (type I) and fast (type IIa, IIx/d) fibers, defined by th
Publikováno v:
Journal of Medicinal Chemistry. 59:2205-2221
Anthracyclines are a class of antitumor compounds that are successful and widely used but suffer from cardiotoxicity and acquired tumor resistance. Formaldehyde interacts with anthracyclines to enhance antitumor efficacy, bypass resistance mechanisms
Autor:
Brian K. Shoichet, Tad H. Koch, Molly S. Shoichet, Christopher K. McLaughlin, Jennifer Logie, Benjamin L. Barthel, Ahil N. Ganesh
Publikováno v:
Molecular pharmaceutics, vol 14, iss 6
While limited drug loading continues to be problematic for chemotherapeutics formulated in nanoparticles, we found that we could take advantage of colloidal drug aggregation to achieve high loading when combined with polymeric excipients. We demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a83fbc2b26280fd991688c8a60c9de38
https://escholarship.org/uc/item/01w4x9zp
https://escholarship.org/uc/item/01w4x9zp
Publikováno v:
Biochemical Pharmacology. 85:439-447
Orlistat has been the most used anti-obesity drug and the mechanism of its action is to reduce lipid absorption by inhibiting gastrointestinal lipases. These enzymes, like carboxylesterases (CESs), structurally belong to the α/β hydrolase fold supe
Autor:
Sean M. Colvin, Daniel L. Rudnicki, David J. Burkhart, Benjamin L. Barthel, Tad H. Koch, Thomas Price Kirby
Publikováno v:
Journal of Medicinal Chemistry. 55:6595-6607
Doxazolidine (doxaz) is a new anthracycline anticancer agent. While structurally similar to doxorubicin (dox), doxaz acts via a distinct mechanism to selectively enhance anticancer activity over cardiotoxicity, the most significant clinical impedimen
Autor:
Daniel C.F. Chan, Benjamin L. Barthel, Margaret Polinkovsky, Zhiyong Zhang, Gary G. Koch, Tad H. Koch, Hengrui Sun, Daniel L. Rudnicki, Christopher D. Coldren
Publikováno v:
Journal of Medicinal Chemistry. 52:7678-7688
Doxazolidine (Doxaz) is a functionally distinct formaldehyde conjugate of doxorubicin (Dox) that induces cancer cell death in Dox-sensitive and resistant cells. Pentyl PABC-Doxaz (PPD) is a prodrug of Doxaz that is activated by carboxylesterase 2 (CE
Autor:
Janice L. Hyatt, Carol C. Edwards, Philip M. Potter, M. Jason Hatfield, Tad H. Koch, Benjamin L. Barthel, Renee C Torres
Publikováno v:
Journal of Medicinal Chemistry. 51:298-304
Doxazolidine (Doxaz), a formaldehyde-doxorubicin (Dox) conjugate, exhibits markedly increased tumor toxicity with respect to Dox without a concurrent increase in toxicity to cardiomyocytes. Pentyl PABC-Doxaz (PPD) is a Doxaz carbamate prodrug that is
Autor:
Tad H, Koch, Benjamin L, Barthel, Brian T, Kalet, Daniel L, Rudnicki, Glen C, Post, David J, Burkhart
Publikováno v:
Topics in current chemistry. 283
The sequence of research leading to a proposal for anthracycline cross-linking of DNA is presented.The clinical anthracycline antitumor drugs are anthraquinones, and as such are redox active. Their redoxchemistry leads to induction of oxidative stres
Autor:
Tad H. Koch, David J. Burkhart, Brian T. Kalet, Daniel L. Rudnicki, Benjamin L. Barthel, Glen C. Post
Publikováno v:
Topics in Current Chemistry ISBN: 9783540758129
The sequence of research leading to a proposal for anthracycline cross-linking of DNA is presented.The clinical anthracycline antitumor drugs are anthraquinones, and as such are redox active. Their redoxchemistry leads to induction of oxidative stres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c7433d267ad4d12dbb12328b9055c5a
https://doi.org/10.1007/128_2007_4
https://doi.org/10.1007/128_2007_4