Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Benjamin L, Zaepfel"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Stress granule formation is a complex and rapidly evolving process that significantly disrupts cellular metabolism in response to a variety of cellular stressors. Recently, it has become evident that different chemical stressors lead to the formation
Externí odkaz:
https://doaj.org/article/3133486195484255863d697d8abf3653
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease that affects upper and lower motor neurons. Familial ALS accounts for a small subset of cases (
Externí odkaz:
https://doaj.org/article/73439273f9f54b0b8585547601e37285
UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction
Autor:
Benjamin L. Zaepfel, Zhe Zhang, Kirstin Maulding, Alyssa N. Coyne, Weiwei Cheng, Lindsey R. Hayes, Thomas E. Lloyd, Shuying Sun, Jeffrey D. Rothstein
Publikováno v:
Cell Reports, Vol 34, Iss 13, Pp 108925- (2021)
Summary: Multiple cellular pathways have been suggested to be altered by the C9orf72 GGGGCC (G4C2) hexanucleotide repeat expansion (HRE), including aspects of RNA regulation such as nonsense-mediated decay (NMD). Here, we investigate the role that ov
Externí odkaz:
https://doaj.org/article/d2e1dffbd2c74482a18aef9b550e6671
Autor:
Alyssa N. Coyne, Ileana Lorenzini, Ching-Chieh Chou, Meaghan Torvund, Robert S. Rogers, Alexander Starr, Benjamin L. Zaepfel, Jennifer Levy, Jeffrey Johannesmeyer, Jacob C. Schwartz, Hiroshi Nishimune, Konrad Zinsmaier, Wilfried Rossoll, Rita Sattler, Daniela C. Zarnescu
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 110-125 (2017)
Amyotrophic lateral sclerosis (ALS) is a synaptopathy accompanied by the presence of cytoplasmic aggregates containing TDP-43, an RNA-binding protein linked to ∼97% of ALS cases. Using a Drosophila model of ALS, we show that TDP-43 overexpression (
Externí odkaz:
https://doaj.org/article/864d5b20cac14a2c8ea1e98ca71ebe07
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neurodegenerative disease affecting both upper and lower motor neurons. The molecular mechanisms underlying disease pathogenesis remain largely unknown. Multiple genetic loci including ge
Externí odkaz:
https://doaj.org/article/894c3232aaa14af6a0eda117bb64e3d8
Autor:
Alyssa N. Coyne, C. Patrick Lusk, Victoria Baskerville, Frank Rigo, Dennis W. Dickson, Benjamin L. Zaepfel, Jeffrey D. Rothstein, Frank C. Bennett
Publikováno v:
Sci Transl Med
Alterations in the components [nucleoporins (Nups)] and function of the nuclear pore complex (NPC) have been implicated as contributors to the pathogenesis of genetic forms of neurodegeneration including C9orf72 amyotrophic lateral sclerosis/frontote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f5c77a909f159864b6a8acd2513ee4
https://doi.org/10.1126/scitranslmed.abe1923
https://doi.org/10.1126/scitranslmed.abe1923
Autor:
Benjamin L. Zaepfel, Jeffrey D. Rothstein, Petr Kalab, Vasilisa Aksenova, Mary Dasso, Lindsey R. Hayes, Lauren Duan
Publikováno v:
Cell Reports. 40:111106
Nuclear clearance of the DNA/RNA-binding protein TDP-43 is a pathologic hallmark of amyotrophic lateral sclerosis and frontotemporal dementia that remains unexplained. Moreover, our current understanding of TDP-43 nucleocytoplasmic shuttling does not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5748a2a51ebfa447bdd4cc343b5b4f6a
https://doi.org/10.1016/j.celrep.2022.111106
https://doi.org/10.1016/j.celrep.2022.111106
Autor:
Hannah Trost, Dhruv Sareen, Clive N. Svendsen, Kelly Bowen, Amnon Harel, Alyssa N. Coyne, Jeffrey D. Rothstein, Yuval Salzberg, Boris Fitchman, Benjamin L. Zaepfel, Frank Rigo, Lindsey R. Hayes
Nucleocytoplasmic transport, controlled by the nuclear pore complex, has recently emerged as a pathomechanism underlying neurodegenerative diseases including C9orf72 ALS/FTD. However, little is known about the underlying molecular events and the unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf8b7adb736c81e44d001d547a68087
https://doi.org/10.1101/2020.02.13.947721
https://doi.org/10.1101/2020.02.13.947721
Autor:
Robert S. Rogers, Konrad E. Zinsmaier, Jacob C. Schwartz, Alexander Starr, Daniela C. Zarnescu, Hiroshi Nishimune, Rita Sattler, Ileana Lorenzini, Ching Chieh Chou, Alyssa N. Coyne, Benjamin L. Zaepfel, Meaghan Torvund, Jennifer L. Levy, Wilfried Rossoll, Jeffrey Johannesmeyer
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 110-125 (2017)
Amyotrophic lateral sclerosis (ALS) is a synaptopathy accompanied by the presence of cytoplasmic aggregates containing TDP-43, an RNA-binding protein linked to ∼97% of ALS cases. Using a Drosophila model of ALS, we show that TDP-43 overexpression (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d160abc188e75d2d0f6777379fc02b39
http://www.sciencedirect.com/science/article/pii/S2211124717313037
http://www.sciencedirect.com/science/article/pii/S2211124717313037
Autor:
Alyssa N, Coyne, Benjamin L, Zaepfel, Lindsey, Hayes, Boris, Fitchman, Yuval, Salzberg, En-Ching, Luo, Kelly, Bowen, Hannah, Trost, Stefan, Aigner, Frank, Rigo, Gene W, Yeo, Amnon, Harel, Clive N, Svendsen, Dhruv, Sareen, Jeffrey D, Rothstein
Publikováno v:
Neuron
Through mechanisms that remain poorly defined, defects in nucleocytoplasmic transport and accumulations of specific nuclear-pore-complex-associated proteins have been reported in multiple neurodegenerative diseases, including C9orf72 Amyotrophic Late
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ad4f799bb0c747ac0c6d23c60551eb0
https://pubmed.ncbi.nlm.nih.gov/32673563
https://pubmed.ncbi.nlm.nih.gov/32673563