Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Benjamin Klapholz"'
Autor:
Tianchi Chen, Cecilia H. Fernández-Espartero, Abigail Illand, Ching-Ting Tsai, Yang Yang, Benjamin Klapholz, Pierre Jouchet, Mélanie Fabre, Olivier Rossier, Bianxiao Cui, Sandrine Lévêque-Fort, Nicholas H. Brown, Grégory Giannone
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Morphogenesis requires building stable macromolecular structures from highly dynamic proteins. Muscles are anchored by long-lasting integrin adhesions to resist contractile force. However, the mechanisms governing integrin diffusion, immobil
Externí odkaz:
https://doaj.org/article/682f12c94da44bf980a2305aa58e3148
Autor:
Benjamin Klapholz, PhD, Heather Levy, Ramesh Kumbha, PhD, Nora Hosny, Michael E. D'Angelo, PhD, Bernhard J. Hering, MD, Christopher Burlak, PhD
Publikováno v:
Surgery Open Science, Vol 4, Iss , Pp 26-31 (2021)
Background: Genetically engineered porcine donors are a potential solution for the shortage of human organs for transplantation. Incompatibilities between humans and porcine donors are largely due to carbohydrate xenoantigens on the surface of porcin
Externí odkaz:
https://doaj.org/article/700d4fc5ead644fe832e4b0789978a53
Autor:
Mingxi Yao, Benjamin T. Goult, Benjamin Klapholz, Xian Hu, Christopher P. Toseland, Yingjian Guo, Peiwen Cong, Michael P. Sheetz, Jie Yan
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Talin is a mechanosensing cytoplasmic adaptor that links integrin cell adhesion receptors to the actin cytoskeleton. Here the authors measure the force-dependent folding and refolding kinetics of all talin rod domains to propose that talin can functi
Externí odkaz:
https://doaj.org/article/bab088eae21c4aa09d879414bfbc9a59
Autor:
Xuyao Liu, Yinan Wang, Mingxi Yao, Karen B. Baker, Benjamin Klapholz, Nicholas H. Brown, Benjamin T. Goult, Jie Yan
Vinculin is a mechanosensitive adapter protein that links the actin network to cell-extracellular matrix adhesions and cell-cell adhesions. It is perhaps the best characterized mechanoeffector, as it is recruited to sites of adhesion in response to f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3afaf84ac996f2c4a2d6e06b4a5b1517
https://doi.org/10.1101/2023.05.25.542235
https://doi.org/10.1101/2023.05.25.542235
Autor:
Ramesh Kumbha, Benjamin Klapholz, Heather Levy, Nora Hosny, Michael E. D'Angelo, Bernhard J. Hering, Christopher Burlak
Publikováno v:
Surgery Open Science, Vol 4, Iss, Pp 26-31 (2021)
Surgery Open Science
Surgery Open Science
Background Genetically engineered porcine donors are a potential solution for the shortage of human organs for transplantation. Incompatibilities between humans and porcine donors are largely due to carbohydrate xenoantigens on the surface of porcine
Autor:
Modassir Choudhry, Tom Henley, Benjamin Klapholz, Rohan Sivapalan, Trevor N. Collingwood, Elisavet Papadimou, Nevena Milosavljevic, Anatoly Vasilyev, Tilmann Bürckstümmer, Sejla Salic, Samir Barbaria, Anna Sieber
Argonautes are nucleases that can be programmed by short oligonucleotides to cleave complementary sequences. Here, we performed an unbiased bioinformatic search to mine bacterial genomes for prokaryotic Argonautes (pAgos) harboring a PIWI domain. Our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bce3af633d604a326016fdecf937b00
https://doi.org/10.1101/2021.03.15.435463
https://doi.org/10.1101/2021.03.15.435463
Publikováno v:
Genetics. 205:125-137
In eukaryotic cells, the organization of genomic DNA into chromatin regulates many biological processes, from the control of gene expression to the regulation of chromosome segregation. The proper maintenance of this structure upon cell division is t
Autor:
Benjamin Klapholz, Jie Yan, Christopher P. Toseland, Peiwen Cong, Benjamin T. Goult, Michael P. Sheetz, Yingjian Guo, Mingxi Yao, Xian Hu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nature Communications
Nature Communications
Talin, a force-bearing cytoplasmic adapter essential for integrin-mediated cell adhesion, links the actin cytoskeleton to integrin-based cell–extracellular matrix adhesions at the plasma membrane. Its C-terminal rod domain, which contains 13 helica
Autor:
Anca Neluta Dragu, Elena Daniela Aflorei, Serban Radian, Benjamin Klapholz, Nina Moderau, Márta Korbonits, Chrisostomos Prodromou, Paulo S. Ribeiro, Chenghao Chen, Ralf Stanewsky
Publikováno v:
Journal of Medical Genetics
BackgroundHeterozygous germline loss-of-function mutations in the aryl hydrocarbon receptor-interacting protein gene (AIP) predispose to childhood-onset pituitary tumours. The pathogenicity of missense variants may pose difficulties for genetic couns
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a73a6761fc9062ff63fbc0f3bc85dc
http://sro.sussex.ac.uk/id/eprint/81184/1/jmedgenet-2017-105191.pdf
http://sro.sussex.ac.uk/id/eprint/81184/1/jmedgenet-2017-105191.pdf
Autor:
Benjamin Klapholz, Nicholas H. Brown
Talin has emerged as the key cytoplasmic protein that mediates integrin adhesion to the extracellular matrix. In this Review, we draw on experiments performed in mammalian cells in culture and Drosophila to present evidence that talin is the most imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b1dc15294d878d022b3f3b189763bc
https://www.repository.cam.ac.uk/handle/1810/266475
https://www.repository.cam.ac.uk/handle/1810/266475