Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Benjamin Keserü"'
Autor:
Annemarieke E. Loot, Isabelle Moneke, Benjamin Keserü, Matthias Oelze, Tetyana Syzonenko, Andreas Daiber, Ingrid Fleming
Publikováno v:
PLoS ONE, Vol 7, Iss 12 (2012)
Externí odkaz:
https://doaj.org/article/ac2326c6964948f8930b727b93a80d07
Autor:
Annemarieke E Loot, Isabelle Moneke, Benjamin Keserü, Matthias Oelze, Tetyana Syzonenko, Andreas Daiber, Ingrid Fleming
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46065 (2012)
In the systemic circulation, 11,12-epoxyeicosatrienoic acid (11,12-EET) elicits nitric oxide (NO)- and prostacyclin-independent vascular relaxation, partially through the activation of large conductance Ca(2+)-activated potassium (BK) channels. Howev
Externí odkaz:
https://doaj.org/article/da045c6c4bb34ed49bc667d328ffb7eb
Autor:
Ralf P. Brandes, Ingrid Fleming, Eduardo Barbosa-Sicard, Bruce D. Hammock, Thomas Braun, Timo Frömel, Marcus Krüger, Benjamin Keserü, Christophe Morisseau
Publikováno v:
Journal of Biological Chemistry. 284:28156-28163
Inhibition of the soluble epoxide hydrolase (sEH) has beneficial effects on vascular inflammation and hypertension indicating that the enzyme may be a promising target for drug development. As the enzymatic core of the hydrolase domain of the human s
Autor:
Bruce D. Hammock, Thomas Gudermann, Norbert Weissmann, Alexander Dietrich, Rudi Busse, Ingrid Fleming, Rüdiger Popp, John R. Falck, Beate Fisslthaler, Benjamin Keserü, Eduardo Barbosa-Sicard
Publikováno v:
The FASEB Journal. 22:4306-4315
Recent findings have indicated a role for cytochrome P-450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) in acute hypoxic pulmonary vasoconstriction (HPV). Given that the intracellular concentration of EETs is determined by the soluble e
Autor:
Alexandra Buckley, Julie Briody, Campbell H. Thompson, Susan E. Ozanne, Benjamin Keserü, Madeline Thompson
Publikováno v:
Metabolism. 54:500-507
An intrauterine environment may play a role in predisposing a developing fetus to metabolic diseases during adulthood. We investigated the hypothesis that a maternal diet high in omega-6 polyunsaturated fat can modify the programming of an offspring'
Autor:
Beate Fisslthaler, Norbert Weissmann, Benjamin Keserü, Hiromasa Tanaka, Ingrid Fleming, Ralph T. Schermuly, Bruce D. Hammock, Eduardo Barbosa-Sicard
Aims The C-terminal domain of the soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs) to their less active diols, while the N-terminal domain demonstrates lipid phosphatase activity. As EETs are potent vasoconstrictors in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fa86416529d876af2ef1dc64b8dc49
https://europepmc.org/articles/PMC2860707/
https://europepmc.org/articles/PMC2860707/
Publikováno v:
Circulation. 118
The soluble epoxide hydrolase (sEH), which is expressed in pulmonary artery smooth muscle cells, metabolizes cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) to their less active diols. Preliminary findings indicate a role o
Publikováno v:
Circulation research. 100(2)
The rate-limiting enzyme for cholesterol synthesis, the hydroxy-methylglutaryl coenzyme A reductase (HCR), is phosphorylated by the AMP-activated protein kinase (AMPK). As shear stress activates the AMPK in endothelial cells, we determined whether it
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 11(15)
Resveratrol and its analogs are promising cancer chemoprevention agents, currently under investigation in clinical trials. However, patients administered other plant polyphenols experienced severe diarrhea, likely due to an increase in intracellular