Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Benjamin Keepers"'
Autor:
Gregory Farber, Yanhan Dong, Qiaozi Wang, Mitesh Rathod, Haofei Wang, Michelle Dixit, Benjamin Keepers, Yifang Xie, Kendall Butz, William J. Polacheck, Jiandong Liu, Li Qian
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Endothelial cells are a heterogeneous population with various organ-specific and conserved functions that are critical to organ development, function, and regeneration. Here we report a Sox17-Erg direct reprogramming approach that uses cardi
Externí odkaz:
https://doaj.org/article/025f0f41f6b54201a14204c9a78b46fa
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102204- (2023)
Summary: Direct cardiac reprogramming refers to the conversion of fibroblasts into cardiomyocyte-like cells (iCMs) without going through an intermediate progenitor stage. Here, we present a protocol for direct cardiac reprogramming in mice using Ascl
Externí odkaz:
https://doaj.org/article/4ff20ddf6f9647baa40d1eb9ed661b8a
Publikováno v:
STAR Protocols, Vol 1, Iss 1, Pp 100010- (2020)
Summary: Direct cardiac reprogramming, the conversion of fibroblasts into cardiomyocyte-like cells (iCMs), is an attractive approach to heal the injured heart. Here we present a new approach to human cardiac reprogramming that utilizes a polycistroni
Externí odkaz:
https://doaj.org/article/2da7444fe0eb4975baa953138aa9853a
Publikováno v:
Circulation Research. 131
Direct reprogramming has revolutionized the fields of stem cell biology and regenerative medicine, making it possible to interconvert somatic cell fates without intermediary pluripotency. Although studies have identified different transcription facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be9bdcfe7dc3a8b5cc20decb03900fd0
https://doi.org/10.1161/res.131.suppl_1.p1006
https://doi.org/10.1161/res.131.suppl_1.p1006
Autor:
Haofei Wang, Benjamin Keepers, Yunzhe Qian, Yifang Xie, Marazzano Colon, Jiandong Liu, Li Qian
Publikováno v:
Cell Stem Cell. 29:1491-1504.e9
Direct reprogramming has revolutionized the fields of stem cell biology and regenerative medicine. However, the common mechanisms governing how reprogramming cells undergo transcriptome and epigenome remodeling (i.e., regulatome remodeling) have not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730072165c1bf188839b60f09e060feb
https://doi.org/10.1016/j.stem.2022.09.006
https://doi.org/10.1016/j.stem.2022.09.006
Publikováno v:
Biochim Biophys Acta Mol Cell Res
Substantial progress is being made in the field cardiac reprogramming, and those in the field are hopeful that the technology will be formulated for therapeutic use. Beyond the excitement around generating a revolutionary new approach for treating is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9a58727800c4572f36f881f32199cc
https://europepmc.org/articles/PMC6911029/
https://europepmc.org/articles/PMC6911029/
Publikováno v:
STAR Protoc
STAR Protocols, Vol 1, Iss 1, Pp 100010-(2020)
STAR Protocols, Vol 1, Iss 1, Pp 100010-(2020)
Summary: Direct cardiac reprogramming, the conversion of fibroblasts into cardiomyocyte-like cells (iCMs), is an attractive approach to heal the injured heart. Here we present a new approach to human cardiac reprogramming that utilizes a polycistroni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd8ee6cb7ff39f62871e329497e509c
https://doi.org/10.1016/j.xpro.2019.100010
https://doi.org/10.1016/j.xpro.2019.100010
Autor:
Elmira Kirichenko, Katelyn Fleisch, Edward Enners, Kenneth D. Irvine, Benjamin Keepers, Consuelo Ibar
Hippo signaling is regulated by biochemical and biomechanical cues that influence the cytoskeleton, but the mechanisms that mediate this have remained unclear. We show that all three mammalian Ajuba family proteins – AJUBA, LIMD1, and WTIP - exhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d203bd9164cd91d99a160b74732cc8
https://europepmc.org/articles/PMC5897721/
https://europepmc.org/articles/PMC5897721/
Autor:
Jan F. Prins, Xu Gao, Jiandong Liu, Ziqing Liu, Weining Shen, Tiffany A. Garbutt, Joshua D. Welch, Hong Ma, Benjamin Keepers, Li Wang, Li Qian, Yang Zhou
Publikováno v:
Cell Stem Cell
Direct cellular reprogramming provides a powerful platform to study cell plasticity and dissect mechanisms underlying cell fate determination. Here, we report a single-cell transcriptomic study of human cardiac (hiCM) reprogramming that utilizes an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729a4e53b08a8f8f6baaa1f0944fb143
https://pubmed.ncbi.nlm.nih.gov/31230860
https://pubmed.ncbi.nlm.nih.gov/31230860