Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Benjamin K. Ayida"'
Autor:
Frank Ruebsam, Lian-Sheng Li, Jingjing Zhao, Nebojsa Stankovic, Peter S. Dragovich, Zhongxiang Sun, Thomas M. Bertolini, Yuefen Zhou, Benjamin K. Ayida, Douglas E. Murphy
Publikováno v:
Tetrahedron Letters. 49:811-815
A general procedure is described for the preparation of 6-substituted-5-hydroxy-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid ethyl esters (6-substituted-5-hydroxy-3(2H)-pyridazinone-4-carboxylic acid ethyl esters). These compounds are shown to unde
Autor:
Yuefen Zhou, Tran Chinh Viet, Thomas M. Bertolini, Douglas E. Murphy, Peter S. Dragovich, Frank Ruebsam, Stephen E. Webber, Zhongxiang Sun, Lian-Sheng Li, Benjamin K. Ayida, Nebojsa Stankovic, Jingjing Zhao
Publikováno v:
Synthesis. 2007:3301-3308
2,6-Disubstituted 5-hydroxy-3(2 H)-pyridazinone-4-carboxylic acid ethyl esters were synthesized from α-keto esters via an efficient three-step sequence including hydrazone formation, acylation with ethyl malonyl chloride, and subsequent Dieckmann cy
Autor:
Benjamin K. Ayida, Vlad E. Gregor, Douglas E. Murphy, Klaus B. Simonsen, Dionisios Vourloumis, Geoffrey C. Winters, Sarah Fish, Daniel Wall, Jamie M. Froelich, Zhongxiang Sun, Thomas Hermann, Yuefen Zhou
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:4942-4949
We report the structure-guided discovery, synthesis, and initial characterization of 3,5-diamino-piperidinyl triazines (DAPT), a novel translation inhibitor class that targets bacterial rRNA and exhibits broad-spectrum antibacterial activity. DAPT co
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2457-2460
Syntheses of dehydroalanine derivatives via a solid-support route, starting from selenocystein, and via conventional solution phase chemistry are described along with initial biological testing. The target compounds were designed as mimetics of the d
Autor:
Benjamin K. Ayida, Masayuki Takahashi, Klaus B. Simonsen, Qing Han, Thomas Hermann, Dionisios Vourloumis, Qiang Zhao, Sarah Shandrick, Geoffrey C. Winters
Publikováno v:
Angewandte Chemie International Edition. 43:3177-3182
Autor:
Masayuki Takahashi, Benjamin K. Ayida, Dionisios Vourloumis, Qiang Zhao, Qing Han, Sofia Barluenga, Thomas Hermann, Littlefield Ethel S, Geoffrey C. Winters, Sarah Shandrick, Klaus B. Simonsen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:713-718
RNA recognition by natural aminoglycoside antibiotics depends on the 2-deoxystreptamine (2-DOS) scaffold which participates in specific hydrogen bonds with the ribosomal decoding-site target. Three-dimensional structure information has been used for
Autor:
Benjamin K Ayida, Thomas Hermann, Klaus Baek Simonsen, Dionisios Vourloumis, Geoffrey C. Winters, Masayuki Takahashi, Sofia Barluenga
Publikováno v:
Tetrahedron Letters. 44:2807-2811
An efficient and highly versatile synthesis of two libraries 1(x,y) and 2-Ar(x,y,z) or 2-R 2 (x,y,w) based on the privileged benzimidazole scaffold is described. Our design is aimed at obtaining molecules, biased for binding to RNA targets, by incorp
Autor:
Sarah Shandrick, Geoffrey C. Winters, Masayuki Takahashi, Klaus B. Simonsen, Thomas Hermann, Sofia Barluenga, Benjamin K. Ayida, Dionisios Vourloumis, Qiang Zhao, Seema Qamar
Publikováno v:
ChemBioChem. 3:1223-1228
Natural aminoglycoside antibiotics recognize an internal loop of bacterial ribosomal-decoding-site RNA by binding to the deep groove of the RNA structure. We have designed, synthesized, and tested RNA-targeted paromamine derivatives that exploit addi
Autor:
Geoffrey C. Winters, Sofia Barluenga, Masayuki Takahashi, Sarah Shandrick, Benjamin K. Ayida, Klaus B. Simonsen, Dionisios Vourloumis, Qiang Zhao, Thomas Hermann, Seema Qamar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3367-3372
The ribosomal decoding site is the target of aminoglycoside antibiotics that specifically recognize an internal loop RNA structure. We synthesized RNA-targeted 2,5-dideoxystreptamine-4-amides in which a sugar moiety in natural aminoglycosides is repl
Autor:
Tran Chinh Viet, Benjamin K. Ayida, Peter S. Dragovich, Amit M. Shah, Huiying J. Hou, Peggy A. Thompson, Frank Ruebsam, Jingjing Zhao, Rupal Patel, Daniel A. Norris, Ruhi Kamran, Thomas G. Nolan, Stephen E. Webber, Qing Han, Charles R. Kissinger, Alan X. Xiang, Lian-Sheng Li, Darian M. Bartkowski, Jennifer Brooks, Julia Khandurina, Ellen Okamoto, Zhongxiang Sun, Mei Tsan, Laurie A. LeBrun, Mcguire Helen, Julie K. Blazel, Maria V. Sergeeva, Sun Hee Kim, Yuefen Zhou, Douglas E. Murphy, Richard E. Showalter, Leo Kirkovsky
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(22)
A novel series of non-nucleoside small molecules containing a tricyclic dihydropyridinone structural motif was identified as potent HCV NS5B polymerase inhibitors. Driven by structure-based design and building on our previous efforts in related serie