Výsledky vyhledávání - "Benjamin Kühnemuth"

Akademický článek

Synthetic Lethality Screen Identifies RPS6KA2 as Modifier of Epidermal Growth Factor Receptor Activity in Pancreatic Cancer

Autor: Nada Milosevic, Benjamin Kühnemuth, Leonie Mühlberg, Stefanie Ripka, Heidi Griesmann, Carolin Lölkes, Malte Buchholz, Daniela Aust, Christian Pilarsky, Sebastian Krug, Thomas Gress, Patrick Michl

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 12, Pp 1354-1362 (2013)

Pancreatic cancer is characterized by a high degree of resistance to chemotherapy. Epidermal growth factor receptor (EGFR) inhibition using the small-molecule inhibitor erlotinib was shown to provide a small survival benefit in a subgroup of patients

Externí odkaz: https://doaj.org/article/83e23b3388324c8393c98fa1bcd9721d

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Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF

Autor: Konstantin Schnell, Stefan Endres, Bastian Meyer, Patrick Layritz, David Anz, Viola Vetter, Maximilian Martin Ludwig Knott, Juliane Gruen, Ignazio Piseddu, Benjamin Kühnemuth, Carolin Perleberg, Natascha Röhrle, Gabriela M. Wiedemann, Stefan Moder, Stephan Eiber, Moritz Rapp

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 205(8)

CCL22 is a key mediator of leukocyte trafficking in inflammatory immune responses, allergy, and cancer. It acts by attracting regulatory T cells and Th2 cells via their receptor CCR type 4 (CCR4). Beyond its role in inflammation, CCL22 is constitutiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aab805f782add024f96a3450feff032
https://pubmed.ncbi.nlm.nih.gov/32907996

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CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine (2019)

Rapp et al. demonstrate that dendritic cells in the lymph node secrete CCL22 to build cell–cell contacts with CCR4-expressing regulatory T cells, leading to immune suppression. Conversely, CCL22 deficiency results in enhanced T cell immunity, shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5d66c5c42af97bf53bba3283fe57d7
https://mediatum.ub.tum.de/1539462

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CUX1 modulates polarization of tumor-associated macrophages by antagonizing NF-κB signaling

Autor: M Schipper, Albrecht Neesse, Malte Buchholz, H Griesmann, Leonie Mühlberg, Thaddeus T. Wissniowski, Patrick Michl, Benjamin Kühnemuth, Nada Milosevic, Thomas M. Gress

Publikováno v: Oncogene; Vol 34
Oncogene

Many solid cancers including pancreatic ductal adenocarcinoma (PDAC) are characterized by an extensive stromal reaction that is accompanied by infiltrating tumor-associated macrophages (TAMs). The role of TAMs in malignant tumors is only partially un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a32e45a8f75218300e0e220c755f6bf
https://doi.org/10.1038/onc.2013.530

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Cancer cell-derived IL-1α induces CCL22 and the recruitment of regulatory T cells

Autor: Stephan Kruger, Raffael Thaler, Viola Vetter, David Anz, Doris Mayr, Patrick Layritz, Moritz Rapp, Benjamin Kühnemuth, Gabriela M. Wiedemann, Steffen Ormanns, Julia Fesseler, Stefan Endres, Sascha Haubner, Max M. L. Knott

In cancer patients, immunosuppression through regulatory T cells (Treg) is a crucial component of tumor immune evasion and contributes to disease progression. Tumor-infiltrating Treg in particular suppress local effector T cell responses and are asso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a15b49a2dbcba3b517e910b9e58c9f
https://europepmc.org/articles/PMC5048775/

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Prevailing over T cell exhaustion: New developments in the immunotherapy of pancreatic cancer

Autor: Max Schnurr, Christian Bauer, Benjamin Kühnemuth, Peter Duewell, Thomas M. Gress, Steffen Ormanns

Publikováno v: Cancer letters. 381(1)

Pancreatic cancer is one of the most aggressive malignancies and has been considered poorly immunogenic for decades. However, this characterization might be over-simplistic. A more sophisticated approach is needed in order to develop new treatment st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e892146b1651962c97ebd8a4500f41
https://pubmed.ncbi.nlm.nih.gov/26968250

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miRNA dynamics in tumor-infiltrating myeloid cells modulating tumor progression in pancreatic cancer

Autor: Marvin Schober, Bence Sipos, Eithne Costello, Victoria Shaw, Benjamin Kühnemuth, Heidi Griesmann, Sebastian Krug, Patrick Michl, Magdalena Huber, Thomas M. Gress, Leonie Mühlberg

Publikováno v: Oncoimmunology. 5(6)

Myeloid cells including tumor-associated macrophages (TAM) and myeloid-derived suppressor cells (MDSC) are known as important mediators of tumor progression in solid tumors such as pancreatic cancer. Infiltrating myeloid cells have been identified no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45807f0278792d1e4a68d595151805a8
https://pubmed.ncbi.nlm.nih.gov/27471627

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CCL22 impedes T cell activation capacities of dendritic cells by reducing membrane expression of MHC molecules and CD80

Autor: Benjamin Kühnemuth, Ignazio Piseddu, Maximilian Knott, Viola Vetter, Patrick Layritz, Stefan Endres, David Anz

Publikováno v: The Journal of Immunology. 198:133.3-133.3

The chemokine CCL22 is a well known modulator of immune responses. By binding to its receptor CCR4, which is highly expressed on several T cell subtypes as well as dendritic cells (DC), CCL22 mediates chemotaxis of responsive cells, thus influencing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d41b7b00bba324f81c32a7ec8e77259f
https://doi.org/10.4049/jimmunol.198.supp.133.3

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