Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Benjamin J. Povinelli"'
Autor:
Elizabeth A. Griffiths, Michelle C. Golding, Pragya Srivastava, Benjamin J. Povinelli, Smitha R. James, Laurie A. Ford, Meir Wetzler, Eunice S. Wang, Michael J. Nemeth
Publikováno v:
Haematologica, Vol 100, Iss 2 (2015)
Externí odkaz:
https://doaj.org/article/d321b0fe2096492ca63ad08a57e8224e
Autor:
Benjamin J Povinelli, Kathleen M Kokolus, Jason W-L Eng, Christopher W Dougher, Leslie Curtin, Maegan L Capitano, Christi T Sailsbury-Ruf, Elizabeth A Repasky, Michael J Nemeth
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120078 (2015)
The production of new blood cells relies on a hierarchical network of hematopoietic stem and progenitor cells (HSPCs). To maintain lifelong hematopoiesis, HSPCs must be protected from ionizing radiation or other cytotoxic agents. For many years, muri
Externí odkaz:
https://doaj.org/article/4d9fa4f85cf1444286bb1db75d6880c6
Autor:
Cristina Di Genua, Alba Rodriguez-Meira, Emmanouela Repapi, Lauren Jamieson, Claus Nerlov, Roy Drissen, Joana Carrelha, Wei Xiong Wen, Wen Hao Neo, Christopher A.G. Booth, Ruggiero Norfo, Nicki Gray, Supat Thongjuea, Benjamin J. Povinelli, Laura M. Kettyle, Adam J. Mead
Publikováno v:
Haematologica
Somatic mutations in acute myeloid leukemia are acquired sequentially and hierarchically. First, pre-leukemic mutations, such as t(8;21) that encodes AML1-ETO, are acquired within the hematopoietic stem cell compartment, while signaling pathway mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a3cc53ebef163ac23c0d4922f040f5
https://doi.org/10.3324/haematol.2018.205351
https://doi.org/10.3324/haematol.2018.205351
Autor:
Kathleen Marie Kokolus, Haley M Spangler, Benjamin J Povinelli, Matthew R Farren, Kelvin P Lee, Elizabeth Ann Repasky
Publikováno v:
Frontiers in Immunology, Vol 5 (2014)
The ability of dendritic cells to stimulate and regulate T cells is critical to effective anti-tumor immunity. Therefore, it is important to fully recognize any inherent factors which may influence DC function under experimental conditions, especiall
Externí odkaz:
https://doaj.org/article/50cf0049cee244ff85dcb1c51a39c08e
Autor:
Laura Pitzonka, Sumana Ullas, Meenalakshmi Chinnam, Benjamin J Povinelli, Daniel T Fisher, Michelle Golding, Michelle M Appenheimer, Michael J Nemeth, Sharon Evans, David W Goodrich
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97628 (2014)
Co-transcriptionally assembled ribonucleoprotein (RNP) complexes are critical for RNA processing and nuclear export. RNPs have been hypothesized to contribute to the regulation of coordinated gene expression, and defects in RNP biogenesis contribute
Externí odkaz:
https://doaj.org/article/31c60bcf9a9443bcbc3e904fc7e03eef
Autor:
Natalina Elliott, Alba Rodriguez-Meira, Sorcha O’Byrne, Deena Iskander, Ruggiero Norfo, Neil Ashley, Wei Xiong Wen, Anindita Roy, Nicholas Fordham, Booth Cag., Supat Thongjuea, E Louka, Benjamin J. Povinelli, Angela Hamblin, Irene Roberts, J de la Fuente, Mariolina Salio, Adam J. Mead, Georgina Buck, Anupama Rao, Sarah Inglott, Guanlin Wang, Nikolaos Sousos
Juvenile myelomonocytic leukemia (JMML) is a poor-prognosis childhood leukemia usually caused by RAS-pathway mutations. The cellular hierarchy in JMML is poorly characterized, including the identity of leukemia stem cells (LSCs). FACS and single-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c5520ffc57e856d193aa64ba4c8b40
https://hdl.handle.net/11380/1292009
https://hdl.handle.net/11380/1292009
Autor:
Anindita Roy, Sorcha O’Byrne, Adam J. Mead, Christopher A.G. Booth, Josu de la Fuente, Alba Rodriguez Meira, Nikolaos Sousos, Natalina Elliott, Irene Roberts, Nicholas Fordham, Sarah Inglott, Angela Hamblin, Neil Ashley, Gemma Buck, Anupama Rao, Benjamin J. Povinelli, E Louka, Deena Iskander
Juvenile Myelomonocytic Leukemia (JMML) is a poor prognosis childhood leukemia usually caused by germline or somatic RAS-activating mutations. The cellular hierarchy in JMML is poorly characterized, including the identity of leukemia stem cells (LSCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de431a7327044cd1166d53db3156d92
Autor:
Angela Hamblin, Sten Eirik W. Jacobsen, Supat Thongjuea, Adam J. Mead, Benjamin J. Povinelli, Nikolaos Sousos, Alice Giustacchini, Alba Rodriguez-Meira, Bethan Psaila, Verónica Alcolea, Nikolaos Barkas, Sally-Ann Clark, Simon J. McGowan, Gemma Buck, E Louka
Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for resolving transcriptional heterogeneity. However, its application to studying cancerous tissues is currently hampered by the lack of coverage across key mutation hotspots in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2176373d37a9604c24839e2f2b298512
https://doi.org/10.1016/j.molcel.2019.01.009
https://doi.org/10.1016/j.molcel.2019.01.009
Autor:
Natalina Elliott, Sarah Inglott, Phillip R. Bennett, Hashem Koohy, Clara Bueno, Antonio Agraz-Doblas, Thomas A. Milne, P Ancliff, Irene Roberts, Catherine Garnett, Bethan Psaila, Anastasios Karadimitris, David J. H. F. Knapp, Siobhan Rice, Pablo Menendez, Suzanne M. Watt, Anindita Roy, Adam J. Mead, Laura Godfrey, Nicholas T. Crump, Gemma Buck, Gary Wright, Ignacio Varela, Paresh Vyas, Peng Hua, Nicholas Fordham, Benjamin J. Povinelli, Sorcha O’Byrne
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Blood
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Blood
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Human lymphopoiesis is a dynamic lifelong process that starts in utero 6 weeks post-conception. Although fetal B-lymphopoiesis remains poorly defined, it is key to understanding leukemia initiation in early life. Here, we provide a comprehensive anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642d2008d51743a2a9cf8f3eadc4a16b
http://hdl.handle.net/10261/204396
http://hdl.handle.net/10261/204396
The hematopoietic system is well established as a paradigm for the study of cellular hierarchies, their disruption in disease and therapeutic use in regenerative medicine. Traditional approaches to study hematopoiesis involve purification of cell pop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ccef7565712a94f705c294b0364e81d
https://ora.ox.ac.uk/objects/uuid:568d3774-3e32-45c5-9e18-b337cab74761
https://ora.ox.ac.uk/objects/uuid:568d3774-3e32-45c5-9e18-b337cab74761