Výsledky vyhledávání - "Benjamin J. Pettus"

Acid Ceramidase but Not Acid Sphingomyelinase Is Required for Tumor Necrosis Factor-α-induced PGE2 Production

Autor: Benjamin J. Pettus, James S. Norris, Saeed Elojeimy, Toshihiko Kawamori, Youssef H. Zeidan, Tarek A. Taha, Yusuf A. Hannun, Lina M. Obeid

Publikováno v: Journal of Biological Chemistry. 281:24695-24703

Sphingolipids are well established effectors of signal transduction downstream of the tumor necrosis factor (TNF) receptor. In a previous study, we showed that the sphingosine kinase/sphingosine 1-phosphate (S1P) pathway couples TNF receptor to induc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7fdaf02a47590e0654b2f8a385ec4ef
https://doi.org/10.1074/jbc.m604713200

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Sphingolipids in Inflammation: Roles and Implications

Autor: Yusuf A. Hannun, C. E. Chalfant, Benjamin J. Pettus

Publikováno v: Current Molecular Medicine. 4:405-418

Sphingolipids, historically described as potential reservoirs for bioactive lipids, presently define a new family of cellular mediators, joining the well-established glycerolipid-derived mediators of signal transduction such as diacylglycerol, phosph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038e6bb94b6e845a0103ef5fd0d4f2b1
https://doi.org/10.2174/1566524043360573

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BcR-induced apoptosis involves differential regulation of C-16 and C-24-ceramide formation and sphingolipid-dependent activation of the proteasome

Autor: Lou F. M. H. de Leij, Hannie Sietsma, Bart-Jan Kroesen, Jan Willem Kok, Susan Jacobs, Yusuf A. Hannun, Benjamin J. Pettus

Publikováno v: The Journal of Biological Chemistry, 278(17), 14723-14731. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC

In this study, we describe an ordered formation of long- and very long-chain ceramide species in relation to the progression of B-cell receptor (BcR) triggering induced apoptosis. An early and caspase-independent increase in long-chain ceramide speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4a74e4e8b13be56a43af2f897ac688
https://doi.org/10.1074/jbc.m210756200

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Observation of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry

Autor: Peter D. R. Moeller, Bart-Jan Kroesen, Benjamin J. Pettus, Yusuf A. Hannun, Alicia Bielawska, Zdzislaw M. Szulc, Mark Busman

Publikováno v: Rapid Communications in Mass Spectrometry. 17:1203-1211

Normal-phase high-performance liquid chromatography (NP-HPLC) coupled to atmospheric pressure chemical ionization mass spectrometry (APCI-MS) allows qualitative analysis of endogenous ceramide and dihydroceramide species from crude lipid extracts uti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e9b70ad75b3f42a97dfbfddd2e4d0de9
https://doi.org/10.1002/rcm.1043

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Acute Activation of de Novo Sphingolipid Biosynthesis upon Heat Shock Causes an Accumulation of Ceramide and Subsequent Dephosphorylation of SR Proteins

Autor: Charles E. Chalfant, Gary M. Jenkins, Benjamin J. Pettus, Yusuf A. Hannun, L. Ashley Cowart, Paola Signorelli

Publikováno v: Journal of Biological Chemistry. 277:42572-42578

Recent studies are beginning to implicate sphingolipids in the heat stress response. In the yeast Saccharomyces cerevisiae, heat stress has been shown to activate de novo biosynthesis of sphingolipids, whereas in mammalian cells the sphingolipid cera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584ef8c01b9793dd217985e895ebab9f
https://doi.org/10.1074/jbc.m207346200

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Biochemical Mechanisms of the Generation of Endogenous Long Chain Ceramide in Response to Exogenous Short Chain Ceramide in the A549 Human Lung Adenocarcinoma Cell Line

Autor: Alicia Bielawska, Julnar Usta, Benjamin J. Pettus, Michael J. Rossi, Besim Ogretmen, Zdzislaw M. Szulc, Yusuf A. Hannun, Rachel Wood, Lina M. Obeid

Publikováno v: Journal of Biological Chemistry. 277:12960-12969

Treatment of A549 cells with C(6)-ceramide resulted in a significant increase in the endogenous long chain ceramide levels, which was inhibited by fumonisin B1 (FB1), and not by myriocin (MYR). The biochemical mechanisms of generation of endogenous c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9664e9f4c96905b05976da870dddc0f
https://doi.org/10.1074/jbc.m110699200

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FAS Activation Induces Dephosphorylation of SR Proteins

Autor: Benjamin J. Pettus, Bart-Jan Kroesen, Sehamuddin Galadari, Besim Ogretmen, Charles E. Chalfant, Yusuf A. Hannun

Publikováno v: Journal of Biological Chemistry. 276:44848-44855

The search for potential targets for ceramide action led to the identification of ceramide-activated protein phosphatases (CAPP). To date, two serine/threonine protein phosphatases, protein phosphatase 2A (PP2A) and protein phosphatase 1 (PP1), have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3cbfa7fe959b5de1b3b3bcf50c9ca27
https://doi.org/10.1074/jbc.m106291200

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Generation of Interhalogen Fluorides under Mild Conditions: A Comparison of Sluggish and Reactive Interhalogen Fluorides

Autor: Mark J. Horney, Dale F. Shellhamer, Joy Merry Stringer, John M. Dobrolsky, Benjamin J. Pettus, Tobiah L. Pettus, Robert George Syvret, Victor L. Heasley

Publikováno v: The Journal of Organic Chemistry. 64:1094-1098

Interhalogen fluorides (XF; X = I, Br, or Cl) generated from xenon difluoride (XeF2) or triethylamine trihydrofluoride (TREAT HF) with iodine (I2), N-halosuccinimides (NXS; X = I, Br, or Cl), or alkylhypohalites (ROX; R = CH3 or t-Bu, X = Br or Cl) w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2c3544474d85945df361ccd2ed5fe53
https://doi.org/10.1021/jo972319g

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A mild method for introducing iodine monofluoride into alkenes and iodination of aromatics using xenon difluoride

Autor: Joy Merry Stringer, Brian C. Jones, Tobiah L. Pettus, Dale F. Shellhamer, Victor L. Heasley, Benjamin J. Pettus

Publikováno v: Journal of Fluorine Chemistry. 88:37-39

Reaction of xenon difluoride (XeF2) and iodine (I2) or N-iodosuccinimide (NIS) with alkenes gives iodofluoro products in good yields. Aromatics react with XeF2 and I2 or NIS to undergo electrophilic aromatic iodination. Iodine monofluoride (IF) gener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b78fb05e2ad218579dc3807a63590662
https://doi.org/10.1016/s0022-1139(97)00133-4

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