Výsledky vyhledávání - "Benjamin J. Gerovac"

Chloride channel accessory 1 gene deficiency causes selective loss of mucus production in a new pig model

Autor: Shamus P. Keeler, Jennifer Yantis, Benjamin J. Gerovac, Samuel L. Youkilis, Stephanie Podgorny, Dailing Mao, Yong Zhang, Kristin M. Whitworth, Bethany Redel, Melissa S. Samuel, Kevin D. Wells, Randall S. Prather, Michael J. Holtzman

Publikováno v: Am J Physiol Lung Cell Mol Physiol

Morbidity and mortality of respiratory diseases are linked to airway obstruction by mucus but there are still no specific, safe, and effective drugs to correct this phenotype. The need for better treatment requires a new understanding of the basis fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94d469409d87497a9fac037ed67bc26
https://europepmc.org/articles/PMC9142155/

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Basal epithelial stem cells cross an alarmin checkpoint for postviral lung disease

Autor: Erika C. Crouch, Christy Hoffmann, Samantha A. Morris, Jennifer Alexander-Brett, Stephen P Austin, Derek E. Byers, Kuangying Yang, Matthew Wallace, Kenji Kamimoto, Yong Zhang, Eugene Agapov, Shamus P. Keeler, Benjamin J. Gerovac, Michael J. Holtzman, Michael E. Hughes, Jennifer Yantis, Kelly A Gissy, Kangyun Wu

Publikováno v: J Clin Invest

Epithelial cells are charged with protection at barrier sites, but whether this normally beneficial response might sometimes become dysfunctional still needs definition. Here, we recognized a pattern of imbalance marked by basal epithelial cell growt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446449425fa07db59d06ff6cb2c25b9c
https://doi.org/10.1172/jci149336

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Group 2 Innate Lymphoid Cells Must Partner with the Myeloid-Macrophage Lineage for Long-Term Postviral Lung Disease

Autor: Derek E. Byers, Xinyu Wang, Eugene Agapov, Susan Gilfillan, Marco Colonna, Yong Zhang, Benjamin J. Gerovac, Kangyun Wu, Michael J. Holtzman, Shamus P. Keeler

Publikováno v: J Immunol

Group 2 innate lymphoid cells (ILC2s) are implicated in host defense and inflammatory disease, but these potential functional roles need more precise definition, particularly using advanced technologies to better target ILC2s and engaging experimenta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048731e4a7b0120aa09a218bc4ed50ee
https://pubmed.ncbi.nlm.nih.gov/32641386

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Epithelial–Immune Cell Interactions for Drug Discovery in Chronic Obstructive Pulmonary Disease

Autor: Joshua R. Chartock, Shamus P. Keeler, Kangyun Wu, Xinyu Wang, Derek E. Byers, Arthur G. Romero, Michael J. Holtzman, Benjamin J. Gerovac

New studies of chronic obstructive pulmonary disease (COPD) are revealing the key role of airway epithelial cells and innate immune cells in the initiation, exacerbation, and progression of airway disease. An emerging scheme focuses on expansion of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23501bec5be809b1d84d5ff6cff3fe64
https://europepmc.org/articles/PMC6321995/

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Respiratory Enterovirus (like Parainfluenza Virus) Can Cause Chronic Lung Disease if Protection by Airway Epithelial STAT1 Is Lost

Autor: Kangyun Wu, Dailing Mao, Benjamin J. Gerovac, Michael J. Holtzman, Laurie L Shornick, Shamus P. Keeler, Yong Zhang, Xinyu Wang, Eugene Agapov

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 202(8)

Epithelial barrier cells are proposed to be critical for host defense, and airway epithelial cell capacity for IFN signal transduction is presumed to protect against respiratory viral infection. However, it has been difficult to fully test these conc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b99bffa33a9fe920d06950cc0fc825
https://pubmed.ncbi.nlm.nih.gov/30804041

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Submersion and Hypoxia Inhibit Ciliated Cell Differentiation in a Notch-Dependent Manner

Autor: Benjamin J. Gerovac, Matthias Salathe, Gregory E. Conner, Nathalie Baumlin, Monica Guiselle Valencia, Nevis Fregien

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 51:516-525

The epithelium that lines the conducting airways is composed of several distinct cell types that differentiate from common progenitor cells. The signals that control fate selection and differentiation of ciliated cells, a major component of the epith

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e618c685ca65cf9168cca1256a5f70ad
https://doi.org/10.1165/rcmb.2013-0237oc

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IL-13 Inhibits Multicilin Expression and Ciliogenesis via Janus Kinase/Signal Transducer and Activator of Transcription Independently of Notch Cleavage

Autor: Benjamin J. Gerovac, Nevis Fregien

Publikováno v: American journal of respiratory cell and molecular biology. 54(4)

Loss of ciliated cells and increases in goblet cells are seen in respiratory diseases such as asthma. These changes result in part from reduced differentiation of basal progenitor cells to ciliated cells during injury and repair. The T helper 2 cytok

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3906299c8933b40d50020d56f2f92b
https://pubmed.ncbi.nlm.nih.gov/26414872

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