Výsledky vyhledávání - "Benjamin J. Capoccia"

Development of AO-176, a Next-Generation Humanized Anti-CD47 Antibody with Novel Anticancer Properties and Negligible Red Blood Cell Binding

Autor: Pamela T. Manning, Ronald R. Hiebsch, Daniel S. Pereira, Benjamin J. Capoccia, Robyn J Puro, Michael J. Donio, Myriam N. Bouchlaka, William A. Frazier, Karr Robert W

Publikováno v: Molecular Cancer Therapeutics. 19:835-846

Inhibitors of adaptive immune checkpoints have shown promise as cancer treatments. CD47 is an innate immune checkpoint receptor broadly expressed on normal tissues and overexpressed on many tumors. Binding of tumor CD47 to signal regulatory protein a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167f2f437f2edfd0f87056982e7ae191
https://doi.org/10.1158/1535-7163.mct-19-1079

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260 CD47 antibody, AO-176 demonstrates potent anti-tumor activity in pre-clinical solid tumor xenografts as a single agent and in combination with multiple classes of therapeutics

Autor: Ronald R. Hiebsch, Robyn J Puro, Casey Wilson, Rachel Delston, Daniel S. Pereira, Arun K. Kashyap, Benjamin J. Capoccia, Michael J. Donio, Gabriela Andrejeva

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundCD47 is a cell surface protein expressed on tumors that binds SIRPα on macrophages and dendritic cells resulting in a ”don’t eat me” signal that allows tumors to evade phagocytosis. The highly differentiated monoclonal antibody, AO-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee292c6258da9bb2fc86fcd25d2fc1e
https://doaj.org/article/5ea9add8ab9d4c4297ee134cebe5d2b2

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215 AO-176, a highly differentiated clinical stage anti-CD47 antibody, preferentially binds tumor versus normal cell CD47 when complexed to β1 integrin

Autor: John R. Richards, Daniel S. Pereira, Robyn J Puro, Arun K Kashyap, Vicki Sung, Ronald R. Hiebsch, Prabir Chakraborty, W. Casey Wilson, Michael J. Donio, Carrie Baker Brachmann, Benjamin J. Capoccia

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)

Background Overexpression of CD47 by tumor cells exploits an immune checkpoint preventing tumor recognition and destruction by innate immune cells. Binding of tumor CD47 to SIRPα on macrophages and dendritic cells triggers a ‘don’t eat me’ sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf553c0b15649e4e49fce94c84be056
https://doaj.org/article/b1c4691d570a499f94d4b96fa9ac0ba2

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Novel SIRPα Antibodies That Induce Single-Agent Phagocytosis of Tumor Cells while Preserving T Cells

Autor: Ronald R. Hiebsch, Daniel S. Pereira, Robyn J Puro, Benjamin J. Capoccia, Gabriela Andrejeva, Isra M. Darwech, Michael J. Donio

Publikováno v: J Immunol

The signal regulatory protein α (SIRPα)/CD47 axis has emerged as an important innate immune checkpoint that enables cancer cell escape from macrophage phagocytosis. SIRPα expression is limited to macrophages, dendritic cells, and neutrophils—cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33fcc537b73a653ec81c927080c15780
https://pubmed.ncbi.nlm.nih.gov/33431660

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Abstract P1-10-15: Development of humanized anti-CD47 monoclonal antibodies with differentiated functional profiles

Autor: Pamela T. Manning, Robyn J Puro, S Chanda, RW Karr, Benjamin J. Capoccia, Michael J. Donio, Ronald R. Hiebsch, K. J. M. Liu, K Crowley

Publikováno v: Cancer Research. 78:P1-10

CD47 is a cell surface transmembrane protein that binds to signal regulatory protein alpha (SIRPα) on macrophages and results in a “don't eat me” signal that inhibits phagocytosis. Breast cancer cells, both primary and metastatic, frequently ove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35c4cf714ebedd6fb356f06123e19d58
https://doi.org/10.1158/1538-7445.sabcs17-p1-10-15

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AO-176, a Differentiated Clinical-Stage Anti-CD47 Antibody, Demonstrates Potent Anti-Tumor Activity across Multiple Preclinical Models of B Cell Neoplasms

Autor: John O. Richards, Arun K Kashyap, Mike J Donio, Daniel S. Pereira, Robyn J Puro, Gabriela Andrejeva, Ronald R. Hiebsch, Benjamin J. Capoccia, William C. Wilson

Publikováno v: Blood. 138:2277-2277

Upregulation of CD47, the "don't eat me" signal, on the surface of tumors to evade immune surveillance is a common escape mechanism utilized during hematological malignancy and solid tumor development, progression, and relapse. We recently reported t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37bd47dac7e3b93fc028bb7375979957
https://doi.org/10.1182/blood-2021-152896

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Pre-Clinical Combination of AO-176, a Highly Differentiated Clinical Stage CD47 Antibody, with Either Azacitidine or Venetoclax Significantly Enhances DAMP Induction and Phagocytosis of Acute Myeloid Leukemia

Autor: Mike J Donio, Daniel S. Pereira, Robyn J Puro, Benjamin J. Capoccia, W. Casey Wilson, Isra M. Darwech, Gabriela Andrejeva, Arun K Kashyap

Publikováno v: Blood. 136:9-10

While T cell checkpoint inhibitors are mainstays of cancer immunotherapy, therapies that direct innate immune responses against cancer are lacking. CD47, a "don't eat me" signal, is an innate immune cell checkpoint which binds SIRPα on macrophages a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55374beb68c6604ac9983abbd0087f4f
https://doi.org/10.1182/blood-2020-140528

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Abstract 548: Evaluation of novel SIRP antibodies as potential cancer therapeutics

Autor: Ronald R. Hiebsch, Myriam N. Bouchlaka, Benjamin J. Capoccia, Michael J. Donio, Prabir Chakraborty, W. Casey Wilson, Robyn J. Puro, Daniel S. Pereira

Publikováno v: Cancer Research. 79:548-548

Targeting immune checkpoints of adaptive immunity has shown great therapeutic efficacy in oncology, but in a limited fraction of patients. Innate immune cells represent the most abundant immune cell types in many solid tumors and are often linked to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41d9a7f2357b5040f058ada87ae7d957
https://doi.org/10.1158/1538-7445.am2019-548

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