Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Benjamin J. C. Quah"'
Autor:
Connor H. O’ Meara, Lucy A. Coupland, Farzaneh Kordbacheh, Benjamin J. C. Quah, Chih-Wei Chang, David A. Simon Davis, Anna Bezos, Anna M. Browne, Craig Freeman, Dillon J. Hammill, Pradeep Chopra, Gergely Pipa, Paul D. Madge, Esther Gallant, Courtney Segovis, Angela F. Dulhunty, Leonard F. Arnolda, Imogen Mitchell, Levon M. Khachigian, Ross W. Stephens, Mark von Itzstein, Christopher R. Parish
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Histones, proteins that bind DNA, are toxic for pathogens outside cells but can also cause multi-organ damage as seen in sepsis. Here the authors develop small negatively charged molecules that can be used as histone antidotes, and show that they imp
Externí odkaz:
https://doaj.org/article/47652de3a653433fb4ea511fb90437ea
Autor:
David A. Simon Davis, Sahngeun Mun, Julianne M. Smith, Dillon Hammill, Jessica Garrett, Katharine Gosling, Jason Price, Hany Elsaleh, Farhan M. Syed, Ines I. Atmosukarto, Benjamin J. C. Quah
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
Clinical adoption of immune checkpoint inhibitors in cancer management has highlighted the interconnection between carcinogenesis and the immune system. Immune cells are integral to the tumour microenvironment and can influence the outcome of therapi
Externí odkaz:
https://doaj.org/article/cc2ca5b9547d44eb9994afb8c60fb1c1
Autor:
David A. Simon Davis, Sahngeun Mun, Julianne M. Smith, Dillon Hammill, Jessica Garrett, Katharine Gosling, Jason Price, Hany Elsaleh, Farhan M. Syed, Ines I. Atmosukarto, Benjamin J. C. Quah
Publikováno v:
PloS one. 17(2)
Clinical adoption of immune checkpoint inhibitors in cancer management has highlighted the interconnection between carcinogenesis and the immune system. Immune cells are integral to the tumour microenvironment and can influence the outcome of therapi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2801ab7674aa08e029dbe0a3d99103da
https://pubmed.ncbi.nlm.nih.gov/35226704
https://pubmed.ncbi.nlm.nih.gov/35226704
Autor:
Danushka K Wijesundara, Charani Ranasinghe, Ronald J Jackson, Brett A Lidbury, Christopher R Parish, Benjamin J C Quah
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105366 (2014)
Qualitative characteristics of cytotoxic CD8+ T cells (CTLs) are important in measuring the effectiveness of CTLs in controlling HIV-1 infections. Indeed, in recent studies patients who are naturally resistant to HIV-1 infections have been shown to p
Externí odkaz:
https://doaj.org/article/0e731bca0c8e4a89a7b6be79b78c4e03
Autor:
Paul D. Madge, Gergely Pipa, Dillon J. Hammill, Pradeep Chopra, Benjamin J. C. Quah, Anna Bezos, David Anak Simon Davis, Lucy A. Coupland, Angela F. Dulhunty, Levon M. Khachigian, Christopher R. Parish, Farzaneh Kordbacheh, Connor H. O’ Meara, Imogen Mitchell, Ross W. Stephens, Mark von Itzstein, Courtney Segovis, Chih-Wei Chang, Esther M. Gallant, Leonard F Arnolda, Craig Freeman, Anna Browne
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Extracellular histones in neutrophil extracellular traps (NETs) or in chromatin from injured tissues are highly pathological, particularly when liberated by DNases. We report the development of small polyanions (SPAs) (~0.9–1.4 kDa) that interact e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da1009f901f83eaeea74a8d3ef9f071
https://pubmed.ncbi.nlm.nih.gov/33328478
https://pubmed.ncbi.nlm.nih.gov/33328478
Publikováno v:
Journal of visualized experiments : JoVE. (88)
The ability to monitor T cell responses in vivo is important for the development of our understanding of the immune response and the design of immunotherapies. Here we describe the use of fluorescent target array (FTA) technology, which utilizes vita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a01c1a466b46d9094ae9711f862b647
https://pubmed.ncbi.nlm.nih.gov/24998253
https://pubmed.ncbi.nlm.nih.gov/24998253
Publikováno v:
Journal of Visualized Experiments.
The ability to monitor T cell responses in vivo is important for the development of our understanding of the immune response and the design of immunotherapies. Here we describe the use of fluorescent target array (FTA) technology, which utilizes vita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbee5bf5659c29b3251e8fe5710ffff
https://doi.org/10.3791/51627-v
https://doi.org/10.3791/51627-v
Publikováno v:
Journal of immunological methods. 387(1-2)
CD4(+) T cells play a central role in regulating the immune response. Their effector function is commonly assessed by their capacity to secrete cytokines detected by ELISPOT and intracellular cytokine staining. However, one aspect of their effector f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f915fb5e43f5b1731ad385d68727bd
https://pubmed.ncbi.nlm.nih.gov/23123200
https://pubmed.ncbi.nlm.nih.gov/23123200
Publikováno v:
Cytometry. Part A : the journal of the International Society for Analytical Cytology. 81(8)
Here we describe a multiplex, fluorescence-based, in vivo cytotoxic T-cell assay using the three vital dyes carboxyfluorescein diacetate succinimidyl ester, cell trace violet, and cell proliferation dye efluor 670. When used to label cells in combina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb42c7866030bdcb5940fe5a1a90534d
https://pubmed.ncbi.nlm.nih.gov/22740235
https://pubmed.ncbi.nlm.nih.gov/22740235
Publikováno v:
Journal of immunological methods. 379(1-2)
The use of carboxyfluorescein diacetate succinimidyl ester (CFSE) to measure lymphocyte proliferation by flow cytometry has become one of the most widely utilised assays for assessing lymphocyte responses. The properties of CFSE make it ideal for suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a12dfe5e741dc413aed363f033e25f8
https://pubmed.ncbi.nlm.nih.gov/22370428
https://pubmed.ncbi.nlm.nih.gov/22370428