Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Benjamin J. Alper"'
Molecular Structure from Models to Mastery: An Inquiry-Based Study of Human Insulin-Degrading Enzyme
Autor:
Michael A. Araujo, Alexandra A. Barrere, Selena-Rae Tirado, Candace E. Williams, Monica I. Strada, Benjamin J. Alper
Publikováno v:
Journal of Chemical Education. 99:4094-4101
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99d3ca09d29dc421820de59d17b2b4fa
https://doi.org/10.1021/acs.jchemed.1c01285
https://doi.org/10.1021/acs.jchemed.1c01285
Autor:
Bocach Dd, Jillian E. Smith-Carpenter, Jones Kl, Bell Jm, Benjamin J. Alper, Noel D. Lazo, Zheng Q
Here we report proteolysis of synthetic acylated human ghrelin by recombinant human insulin-degrading enzyme (IDE). Kinetic parameters and sites of proteolytic cleavage were evaluated. Ghrelin proteolysis by IDE was inhibited by ethylenediaminetetraa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74d7b94763613848f06e651fec321a6a
https://doi.org/10.1101/2021.06.10.447714
https://doi.org/10.1101/2021.06.10.447714
Publikováno v:
Protein Science. 27:861-873
Here we report the enzymologic characterization of recombinant human pitrilysin metallopeptidase 1 (Pitrm1) and derivative mutants including the arginine‐to‐glutamine substitution mutant Pitrm1 R183Q, which has been implicated in inherited amyloi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b4b4a13ecb2900605c7cdaa6ffc1e4
https://doi.org/10.1002/pro.3380
https://doi.org/10.1002/pro.3380
Publikováno v:
Journal of Chemical Education. 95:146-151
Most biochemical transformations involve more than one substrate. Bisubstrate enzymes catalyze multiple chemical reactions in living systems and include members of the transferase, oxidoreductase, and ligase enzyme classes. Working knowledge of bisub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cce93462a1d7a4c5c692d6529f7c7bad
https://doi.org/10.1021/acs.jchemed.7b00535
https://doi.org/10.1021/acs.jchemed.7b00535
Autor:
Samantha E. Cooper, Jillian E. Smith-Carpenter, Lazaros Stefanidis, Nicholas D. Fusco, Benjamin J. Alper
Publikováno v:
Biochemistry. 57(32)
Insulin-degrading enzyme (IDE) is a 110 kDa chambered zinc metalloendopeptidase that degrades insulin, amyloid β, and other intermediate-sized aggregation prone peptides that adopt β-structures. Structural studies of IDE in complex with multiple ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be1e0fac80ecad418db81d590efd55e
https://pubmed.ncbi.nlm.nih.gov/30004674
https://pubmed.ncbi.nlm.nih.gov/30004674
Autor:
Rajesh K. Yadav, Janet F. Partridge, Brandon R Lowe, Benjamin J. Alper, Sreenath Shanker, Godwin Job
Publikováno v:
The EMBO Journal. 32:2321-2335
Heterochromatin assembly in fission yeast depends on the Clr4 histone methyltransferase, which targets H3K9. We show that the histone deacetylase Sir2 is required for Clr4 activity at telomeres, but acts redundantly with Clr3 histone deacetylase to m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42fc9b256d51524f0383b01fb86afe57
https://doi.org/10.1038/emboj.2013.143
https://doi.org/10.1038/emboj.2013.143
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(6)
Histidine decarboxylase (HDC) is an enzyme that converts histidine to histamine. Inhibition of HDC has several medical applications, and HDC inhibitors are of considerable interest for the study of histidine metabolism. (S)-α-Fluoromethylhistidine d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4045a53074901fe2e6113ad100d2756c
https://pubmed.ncbi.nlm.nih.gov/28228363
https://pubmed.ncbi.nlm.nih.gov/28228363
Autor:
Sayali S. Kukday, Walter K. Schmidt, Marissa C. Ludley, Mary E. Burriss, Benjamin J. Alper, Surya P. Manandhar
Publikováno v:
SLAS Discovery. 17:1348-1361
The insulin-degrading enzyme (IDE) cleaves numerous small peptides, including biologically active hormones and disease-related peptides. The propensity of IDE to degrade neurotoxic Aβ peptides marks IDE as a potential therapeutic target for Alzheime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b65f975ccb9d87be12afb78f2cb721
https://doi.org/10.1177/1087057112451921
https://doi.org/10.1177/1087057112451921
Publikováno v:
Chromosome Research. 20:521-534
Distinct regions of the eukaryotic genome are packaged into different types of chromatin, with euchromatin representing gene rich, transcriptionally active regions and heterochromatin more condensed and gene poor. The assembly and maintenance of hete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd6cf85504b3f10767821fba1a4f530
https://doi.org/10.1007/s10577-012-9288-x
https://doi.org/10.1007/s10577-012-9288-x
Publikováno v:
Biochemical Journal. 398:145-152
Pitrilysin is a bacterial protease that is similar to the mammalian insulin-degrading enzyme, which is hypothesized to protect against the onset of Alzheimer's disease, and the yeast enzymes Axl1p and Ste23p, which are responsible for production of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14226dc60da89f69ff65700420fcb75e
https://doi.org/10.1042/bj20060311
https://doi.org/10.1042/bj20060311