Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Benjamin J., Whalley"'
Autor:
Daniel I. Brierley, Joe R. Harman, Natasha Giallourou, Emma Leishman, Anna Emily Roashan, Ben A.D. Mellows, Heather B. Bradshaw, Jonathan R. Swann, Ketan Patel, Benjamin J. Whalley, Claire M. Williams
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 4, Pp 844-859 (2019)
Abstract Background Muscle wasting, anorexia, and metabolic dysregulation are common side‐effects of cytotoxic chemotherapy, having a dose‐limiting effect on treatment efficacy, and compromising quality of life and mortality. Extracts of Cannabis
Externí odkaz:
https://doaj.org/article/db29cdbd0a4e4245b9247006c7c1688e
A Fiber Alginate Co-culture Platform for the Differentiation of mESC and Modeling of the Neural Tube
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2021)
Alginate hydrogels are a commonly used substrate for in vitro 3D cell culture. These naturally derived biomaterials are highly tunable, biocompatible, and can be designed to mimic the elastic modulus of the adult brain at 1% w/v solution. Recent stud
Externí odkaz:
https://doaj.org/article/0cf22671f34b436daee021a4f5010cd4
Autor:
Chloë Scheldeman, James D. Mills, Aleksandra Siekierska, Ines Serra, Daniëlle Copmans, Anand M. Iyer, Benjamin J. Whalley, Jan Maes, Anna C. Jansen, Lieven Lagae, Eleonora Aronica, Peter A.M. de Witte
Publikováno v:
Neurobiology of Disease, Vol 108, Iss , Pp 225-237 (2017)
Tuberous sclerosis complex (TSC) is a rare, genetic disease caused by loss-of-function mutations in either TSC1 or TSC2. Patients with TSC are neurologically characterized by the presence of abnormal brain structure, intractable epilepsy and TSC-asso
Externí odkaz:
https://doaj.org/article/8813016242de4ceaa701a45244ffacf5
Publikováno v:
Pharmaceuticals, Vol 12, Iss 3, p 104 (2019)
Large conductance, Ca2+-activated K+ (BKCa) channels are widely expressed in the central nervous system, where they regulate action potential duration, firing frequency and consequential neurotransmitter release. Moreover, drug action on, mutations t
Externí odkaz:
https://doaj.org/article/6bac57befbd643379a7297d300e43857
Autor:
Evan C. Rosenberg, Simon Chamberland, Michael Bazelot, Erica R. Nebet, Xiaohan Wang, Sam McKenzie, Swati Jain, Stuart Greenhill, Max Wilson, Nicole Marley, Alejandro Salah, Shanice Bailey, Pabitra Hriday Patra, Rebecca Rose, Nicolas Chenouard, Simón(e) D. Sun, Drew Jones, György Buzsáki, Orrin Devinsky, Gavin Woodhall, Helen E. Scharfman, Benjamin J. Whalley, Richard W. Tsien
Publikováno v:
Neuron. 111:1282-1300.e8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e68cc5a07d1cdf1bcc37730d9ba73c7b
https://doi.org/10.1016/j.neuron.2023.01.018
https://doi.org/10.1016/j.neuron.2023.01.018
Autor:
Tamara Modebadze, Nicola H Morgan, Isabelle A A Pérès, Rebecca D Hadid, Naoki Amada, Charlotte Hill, Claire Williams, Ian M Stanford, Christopher M Morris, Roland S G Jones, Benjamin J Whalley, Gavin L Woodhall
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0147265 (2016)
Animal models of acquired epilepsies aim to provide researchers with tools for use in understanding the processes underlying the acquisition, development and establishment of the disorder. Typically, following a systemic or local insult, vulnerable b
Externí odkaz:
https://doaj.org/article/62dc5808fa0e481ea7127988e2c6b16c
Autor:
Michael Bazelot, Eleni Serafeimidou-Pouliou, Pabitra Hriday Patra, Alister J. McNeish, Claire M. Williams, Benjamin J. Whalley
Publikováno v:
British Journal of Pharmacology
Patra, P H, Serafeimidou-Pouliou, E, Bazelot, M, Whalley, B J, Williams, C M & McNeish, A J 2020, ' Cannabidiol improves survival and behavioural co-morbidities of Dravet syndrome in mice ', British Journal of Pharmacology, vol. 177, no. 12, pp. 2779-2792 . https://doi.org/10.1111/bph.15003
Patra, P H, Serafeimidou-Pouliou, E, Bazelot, M, Whalley, B J, Williams, C M & McNeish, A J 2020, ' Cannabidiol improves survival and behavioural co-morbidities of Dravet syndrome in mice ', British Journal of Pharmacology, vol. 177, no. 12, pp. 2779-2792 . https://doi.org/10.1111/bph.15003
Background and Purpose Dravet syndrome is a severe, genetic form of paediatric epilepsy associated with premature mortality and comorbidities such as anxiety, depression, autism, motor dysfunction, and memory deficits. Cannabidiol is an approved anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeae313f8e17833081a30ff3a74eda6a
http://europepmc.org/articles/PMC7236080
http://europepmc.org/articles/PMC7236080
A Fiber Alginate Co-culture Platform for the Differentiation of mESC and Modeling of the Neural Tube
Publikováno v:
Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 14 (2021)
Frontiers in Neuroscience, Vol 14 (2021)
Alginate hydrogels are a commonly used substrate for in vitro 3D cell culture. These naturally derived biomaterials are highly tunable, biocompatible, and can be designed to mimic the elastic modulus of the adult brain at 1% w/v solution. Recent stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a60a706b261904b474a859d41940fe
http://europepmc.org/articles/PMC7835723
http://europepmc.org/articles/PMC7835723
Publikováno v:
PeerJ, Vol 1, p e214 (2013)
To date, anticonvulsant effects of the plant cannabinoid, cannabidivarin (CBDV), have been reported in several animal models of seizure. However, these behaviourally observed anticonvulsant effects have not been confirmed at the molecular level. To e
Externí odkaz:
https://doaj.org/article/961f3fd787e046f6b65dbb98ac413e73
Publikováno v:
Br J Pharmacol
Anabolic androgenic steroids (AASs) are prescribed for medical conditions related to low testosterone. Abuse of AASs has surged as they become recognised as potent image enhancement drugs. The primary goal of most abusers is to obtain a more attracti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed97dfedeede948c13e6da1e910768bc
https://europepmc.org/articles/PMC7174889/
https://europepmc.org/articles/PMC7174889/
