Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Benjamin J Whalley"'
Autor:
Tamara Modebadze, Nicola H Morgan, Isabelle A A Pérès, Rebecca D Hadid, Naoki Amada, Charlotte Hill, Claire Williams, Ian M Stanford, Christopher M Morris, Roland S G Jones, Benjamin J Whalley, Gavin L Woodhall
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0147265 (2016)
Animal models of acquired epilepsies aim to provide researchers with tools for use in understanding the processes underlying the acquisition, development and establishment of the disorder. Typically, following a systemic or local insult, vulnerable b
Externí odkaz:
https://doaj.org/article/62dc5808fa0e481ea7127988e2c6b16c
A Fiber Alginate Co-culture Platform for the Differentiation of mESC and Modeling of the Neural Tube
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2021)
Alginate hydrogels are a commonly used substrate for in vitro 3D cell culture. These naturally derived biomaterials are highly tunable, biocompatible, and can be designed to mimic the elastic modulus of the adult brain at 1% w/v solution. Recent stud
Externí odkaz:
https://doaj.org/article/0cf22671f34b436daee021a4f5010cd4
Autor:
Chloë Scheldeman, James D. Mills, Aleksandra Siekierska, Ines Serra, Daniëlle Copmans, Anand M. Iyer, Benjamin J. Whalley, Jan Maes, Anna C. Jansen, Lieven Lagae, Eleonora Aronica, Peter A.M. de Witte
Publikováno v:
Neurobiology of Disease, Vol 108, Iss , Pp 225-237 (2017)
Tuberous sclerosis complex (TSC) is a rare, genetic disease caused by loss-of-function mutations in either TSC1 or TSC2. Patients with TSC are neurologically characterized by the presence of abnormal brain structure, intractable epilepsy and TSC-asso
Externí odkaz:
https://doaj.org/article/8813016242de4ceaa701a45244ffacf5
Autor:
Evan C. Rosenberg, Simon Chamberland, Michael Bazelot, Erica R. Nebet, Xiaohan Wang, Sam McKenzie, Swati Jain, Stuart Greenhill, Max Wilson, Nicole Marley, Alejandro Salah, Shanice Bailey, Pabitra Hriday Patra, Rebecca Rose, Nicolas Chenouard, Simón(e) D. Sun, Drew Jones, György Buzsáki, Orrin Devinsky, Gavin Woodhall, Helen E. Scharfman, Benjamin J. Whalley, Richard W. Tsien
Publikováno v:
Neuron. 111:1282-1300.e8
Autor:
Michael Bazelot, Eleni Serafeimidou-Pouliou, Pabitra Hriday Patra, Alister J. McNeish, Claire M. Williams, Benjamin J. Whalley
Publikováno v:
British Journal of Pharmacology
Patra, P H, Serafeimidou-Pouliou, E, Bazelot, M, Whalley, B J, Williams, C M & McNeish, A J 2020, ' Cannabidiol improves survival and behavioural co-morbidities of Dravet syndrome in mice ', British Journal of Pharmacology, vol. 177, no. 12, pp. 2779-2792 . https://doi.org/10.1111/bph.15003
Patra, P H, Serafeimidou-Pouliou, E, Bazelot, M, Whalley, B J, Williams, C M & McNeish, A J 2020, ' Cannabidiol improves survival and behavioural co-morbidities of Dravet syndrome in mice ', British Journal of Pharmacology, vol. 177, no. 12, pp. 2779-2792 . https://doi.org/10.1111/bph.15003
Background and Purpose Dravet syndrome is a severe, genetic form of paediatric epilepsy associated with premature mortality and comorbidities such as anxiety, depression, autism, motor dysfunction, and memory deficits. Cannabidiol is an approved anti
Autor:
Michael Bazelot, Nicholas A. Jones, Melissa Barker-Haliski, H. Steve White, Benjamin J. Whalley, Sarah Glyn, Alister J. McNeish, Pabitra Hriday Patra, Claire M. Williams, Haramrit Sandhu
Publikováno v:
Epilepsia
Patra, P H, Barker-Haliski, M, White, H S, Whalley, B J, Glyn, S, Sandhu, H, Jones, N, Bazelot, M, Williams, C M & McNeish, A J 2019, ' Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models ', Epilepsia, vol. 60, no. 2, pp. 303-314 . https://doi.org/10.1111/epi.14629
Patra, P H, Barker-Haliski, M, White, H S, Whalley, B J, Glyn, S, Sandhu, H, Jones, N, Bazelot, M, Williams, C M & McNeish, A J 2019, ' Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models ', Epilepsia, vol. 60, no. 2, pp. 303-314 . https://doi.org/10.1111/epi.14629
Objective Epilepsy is a progressive neurological disease characterized by recurrent seizures and behavioral comorbidities. We investigated the antiseizure effect of cannabidiol (CBD), in a battery of acute seizure models. Additionally, we defined the
A Fiber Alginate Co-culture Platform for the Differentiation of mESC and Modeling of the Neural Tube
Publikováno v:
Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 14 (2021)
Frontiers in Neuroscience, Vol 14 (2021)
Alginate hydrogels are a commonly used substrate for in vitro 3D cell culture. These naturally derived biomaterials are highly tunable, biocompatible, and can be designed to mimic the elastic modulus of the adult brain at 1% w/v solution. Recent stud
Publikováno v:
PeerJ, Vol 1, p e214 (2013)
To date, anticonvulsant effects of the plant cannabinoid, cannabidivarin (CBDV), have been reported in several animal models of seizure. However, these behaviourally observed anticonvulsant effects have not been confirmed at the molecular level. To e
Externí odkaz:
https://doaj.org/article/961f3fd787e046f6b65dbb98ac413e73
Publikováno v:
Br J Pharmacol
Anabolic androgenic steroids (AASs) are prescribed for medical conditions related to low testosterone. Abuse of AASs has surged as they become recognised as potent image enhancement drugs. The primary goal of most abusers is to obtain a more attracti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed97dfedeede948c13e6da1e910768bc
https://europepmc.org/articles/PMC7174889/
https://europepmc.org/articles/PMC7174889/
Autor:
Royston A, Gray, Benjamin J, Whalley
Publikováno v:
Epileptic disorders : international epilepsy journal with videotape. 22(S1)
Highly purified cannabidiol (CBD) (approved as Epidiolex