Výsledky vyhledávání - "Benjamin J Schiller"

Akademický článek

Defects in the C. elegans acyl-CoA synthase, acs-3, and nuclear hormone receptor, nhr-25, cause sensitivity to distinct, but overlapping stresses.

Autor: Jordan D Ward, Brendan Mullaney, Benjamin J Schiller, Le D He, Sarah E Petnic, Carole Couillault, Nathalie Pujol, Teresita U Bernal, Marc R Van Gilst, Kaveh Ashrafi, Jonathan J Ewbank, Keith R Yamamoto

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e92552 (2014)

Metazoan transcription factors control distinct networks of genes in specific tissues, yet understanding how these networks are integrated into physiology, development, and homeostasis remains challenging. Inactivation of the nuclear hormone receptor

Externí odkaz: https://doaj.org/article/672348cb26964d8ab97c38820135c34d

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Akademický článek

Disruption of the abdominal-B promoter tethering element results in a loss of long-range enhancer-directed Hox gene expression in Drosophila.

Autor: Margaret C W Ho, Benjamin J Schiller, Omar S Akbari, Esther Bae, Robert A Drewell

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e16283 (2011)

There are many examples within gene complexes of transcriptional enhancers interacting with only a subset of target promoters. A number of molecular mechanisms including promoter competition, insulators and chromatin looping are thought to play a rol

Externí odkaz: https://doaj.org/article/6e69661cfb984dadb1e406fbc174b213

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Akademický článek

Functional evolution of cis-regulatory modules at a homeotic gene in Drosophila.

Autor: Margaret C W Ho, Holly Johnsen, Sara E Goetz, Benjamin J Schiller, Esther Bae, Diana A Tran, Andrey S Shur, John M Allen, Christoph Rau, Welcome Bender, William W Fisher, Susan E Celniker, Robert A Drewell

Publikováno v: PLoS Genetics, Vol 5, Iss 11, p e1000709 (2009)

It is a long-held belief in evolutionary biology that the rate of molecular evolution for a given DNA sequence is inversely related to the level of functional constraint. This belief holds true for the protein-coding homeotic (Hox) genes originally d

Externí odkaz: https://doaj.org/article/54818f7f8677431098ff351f308d7890

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Abstract P2-04-03: Circulating tumor DNA (ctDNA) provides molecular monitoring for inflammatory breast cancer (IBC)

Autor: Massimo Cristofanilli, LaiMun Siew, AmirAli Talasaz, Benjamin J Schiller, Gangwu Mei, Laura Austin, Helmy Eltoukhy, Dragan Sebisanovic, Paolo Fortina, Aubrey Zapanta

Publikováno v: Cancer Research. 75:P2-04

Background Inflammatory Breast Cancer (IBC) is a clinicopathologic diagnosis characterized by rapid progression, resistance to treatment and poor prognosis. It is often an incurable disease with complex molecular features including somatic mutations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33a49e281a0e22ae1b8605141819b96f
https://doi.org/10.1158/1538-7445.sabcs14-p2-04-03

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Stalled Spliceosomes Are a Signal for RNAi-Mediated Genome Defense

Autor: James Thompson, Prashanthi Natarajan, Ines A. Drinnenberg, Benjamin J. Schiller, Hiten D. Madhani, John R. Yates, David P. Bartel, Phillip A. Dumesic, James J. Moresco, Changbin Chen

Publikováno v: Cell, vol 152, iss 5
PMC

SummaryUsing the yeast Cryptococcus neoformans, we describe a mechanism by which transposons are initially targeted for RNAi-mediated genome defense. We show that intron-containing mRNA precursors template siRNA synthesis. We identify a Spliceosome-C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e0c560ff5076d037c8dd09402a8244

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Glucocorticoid receptor binds half sites as a monomer and regulates specific target genes

Autor: Rajas Chodankar, Michael R. Stallcup, Lisa C. Watson, Benjamin J. Schiller, Keith R. Yamamoto

Publikováno v: Genome Biology

Background Glucocorticoid receptor (GR) is a hormone-activated, DNA-binding transcriptional regulatory factor that controls inflammation, metabolism, stress responses, and other physiological processes. In vitro, GR binds as an inverted dimer to a mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92d543459599901beb22200193e59cc
https://doi.org/10.1186/s13059-014-0418-y

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Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor genome occupancy in a gene-selective manner

Autor: Benjamin J. Schiller, Dai-Ying Wu, Keith R. Yamamoto, Rajas Chodankar, Michael R. Stallcup

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 11

Ligand activation and DNA-binding dictate the outcome of glucocorticoid receptor (GR)-mediated transcriptional regulation by inducing diverse receptor conformations that interact differentially with coregulators. GR recruits many coregulators via the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf95799b298480b842314ee6372116c
https://pubmed.ncbi.nlm.nih.gov/24591583

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Defects in the C. elegans acyl-CoA Synthase, acs-3, and Nuclear Hormone Receptor, nhr-25, Cause Sensitivity to Distinct, but Overlapping Stresses

Autor: Carole Couillault, Keith R. Yamamoto, Nathalie Pujol, Marc R. Van Gilst, Le D. He, Sarah Petnic, Kaveh Ashrafi, Benjamin J. Schiller, Jordan D. Ward, Brendan C. Mullaney, Jonathan J. Ewbank, Teresita U. Bernal

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2014, 9 (3), pp.e92552. ⟨10.1371/journal.pone.0092552⟩
PLoS ONE, 2014, 9 (3), pp.e92552. ⟨10.1371/journal.pone.0092552⟩
PloS one, vol 9, iss 3
Ward, JD; Mullaney, B; Schiller, BJ; He, LD; Petnic, SE; Couillault, C; et al.(2014). Defects in the C. elegans acyl-CoA synthase, acs-3, and nuclear hormone receptor, nhr-25, cause sensitivity to distinct, but overlapping stresses. PLoS ONE, 9(3). doi: 10.1371/journal.pone.0092552. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/4kq1n91k
PLoS ONE, Vol 9, Iss 3, p e92552 (2014)

International audience; Metazoan transcription factors control distinct networks of genes in specific tissues, yet understanding how these networks are integrated into physiology, development, and homeostasis remains challenging. Inactivation of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96d4bc8614acff33d1491e332facc27
https://hal.archives-ouvertes.fr/hal-02109603/document

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The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals

Autor: Lisa C. Watson, Benjamin J. Schiller, John D. Gross, Keith R. Yamamoto, Miles A. Pufall, Kristopher M. Kuchenbecker

Publikováno v: Nature structural & molecular biology

Glucocorticoid receptor binds to genomic response elements and regulates gene transcription with cell- and gene-specificity. Within a response element, the precise sequence to which the receptor binds has been implicated in directing its structure an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ef37dac03eda9aa3db6e6bb8fcb18e
https://pubmed.ncbi.nlm.nih.gov/23728292

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