Výsledky vyhledávání - "Benjamin J Reed"

Akademický článek

Dynamic Sumoylation of a Conserved Transcription Corepressor Prevents Persistent Inclusion Formation during Hyperosmotic Stress.

Autor: Michelle L Oeser, Triana Amen, Cory M Nadel, Amanda I Bradley, Benjamin J Reed, Ramon D Jones, Janani Gopalan, Daniel Kaganovich, Richard G Gardner

Publikováno v: PLoS Genetics, Vol 12, Iss 1, p e1005809 (2016)

Cells are often exposed to physical or chemical stresses that can damage the structures of essential biomolecules. Stress-induced cellular damage can become deleterious if not managed appropriately. Rapid and adaptive responses to stresses are theref

Externí odkaz: https://doaj.org/article/b2a5989a3c9448ed83d632d3d351ad38

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Real-time imaging of intracellular hydrogen peroxide in pancreatic islets

Autor: Ian R. Sweet, Benjamin J. Reed, Huiliang Zhang, Austin M. Rountree, Adam S. Neal, Kelly Kernan, William R. A. Osborne, Brian Van Yserloo, Wang Wang

Publikováno v: Biochemical Journal. 473:4443-4456

A real-time method to measure intracellular hydrogen peroxide (H 2 O 2 ) would be very impactful in characterizing rapid changes that occur in physiologic and pathophysiologic states. Current methods do not provide the sensitivity, specificity and sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1733a903ea26e917f9bd4a6678ee23c2
https://doi.org/10.1042/bcj20160481

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A Conserved Deubiquitinating Enzyme Uses Intrinsically Disordered Regions to Scaffold Multiple Protein Interaction Sites

Autor: Melissa N. Locke, Richard G. Gardner, Benjamin J. Reed

Publikováno v: Journal of Biological Chemistry. 290:20601-20612

In the canonical view of protein function, it is generally accepted that the three-dimensional structure of a protein determines its function. However, the past decade has seen a dramatic growth in the identification of proteins with extensive intrin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615ed0cca1de050206ea51fedc8ef599
https://doi.org/10.1074/jbc.m115.650952

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Dynamic Sumoylation of a Conserved Transcription Corepressor Prevents Persistent Inclusion Formation during Hyperosmotic Stress

Autor: Daniel Kaganovich, Richard G. Gardner, Triana Amen, Janani Gopalan, Ramon D. Jones, Michelle L. Oeser, Cory M. Nadel, Benjamin J. Reed, Amanda Bradley

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 12, Iss 1, p e1005809 (2016)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18a3d26c04113594496804ba45a3eb0
http://europepmc.org/articles/PMC4723248

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A Conserved Deubiquitinating Enzyme Controls Cell Growth by Regulating RNA Polymerase I Stability

Autor: Eric K. Fredrickson, Emily F. Freed, J. Michael Charette, Melissa N. Locke, Richard G. Gardner, Benjamin J. Reed, Lauren A. Richardson, Susan J. Baserga

Publikováno v: Cell Reports, Vol 2, Iss 2, Pp 372-385 (2012)

Summary Eukaryotic ribosome biogenesis requires hundreds of trans -acting factors and dozens of RNAs. Although most factors required for ribosome biogenesis have been identified, little is known about their regulation. Here, we reveal that the yeast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c156ab9673b1185d291167fbfdd2faf0
http://www.sciencedirect.com/science/article/pii/S2211124712002197

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Clinician, patient and general public beliefs about diagnostic imaging for low back pain: protocol for a qualitative evidence synthesis

Autor: Tammy Hoffmann, Gustavo C Machado, Carissa Bonner, Christopher G. Maher, Denise O'Connor, Adrian C Traeger, Rachelle Buchbinder, Benjamin J Reed

Publikováno v: BMJ Open

IntroductionLittle is known about how to reduce unnecessary imaging for low back pain. Understanding clinician, patient and general public beliefs about imaging is critical to developing strategies to reduce overuse.ObjectiveTo synthesise qualitative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76dd873079fe08ba299b88e335b9205
https://doi.org/10.1136/bmjopen-2017-019470

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A highly energetic process couples calcium influx through L-type calcium channels to insulin secretion in pancreatic β-cells

Autor: Seung-Ryoung Jung, Ian R. Sweet, Benjamin J. Reed

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 297:E717-E727

Calcium (Ca2+) influx is required for the sustained secretion of insulin and is accompanied by a large rate of energy usage. We hypothesize that the energy usage reflects a process [Ca2+/metabolic coupling process (CMCP)] that couples Ca2+ to insulin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abdaa3fcd7116c408b541fcb0c86a071
https://doi.org/10.1152/ajpendo.00282.2009

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Development and characterization of a novel rat model of type 2 diabetes mellitus: the UC Davis type 2 diabetes mellitus UCD-T2DM rat

Autor: Erin K. Digitale, Benjamin J. Reed, James L. Graham, Ian R. Sweet, Kimber L. Stanhope, Bethany P. Cummings, Steven C. Griffen, Denis G. Baskin, Peter J. Havel

Publikováno v: Cummings, Bethany P; Digitale, Erin K; Stanhope, Kimber L; Graham, James L; Baskin, Denis G; Reed, Benjamin J; et al.(2008). Development and characterization of a novel rat model of type 2 diabetes mellitus: the UC Davis type 2 diabetes mellitus UCD-T2DM rat.. American journal of physiology. Regulatory, integrative and comparative physiology, 295(6), R1782-R1793. doi: 10.1152/ajpregu.90635.2008. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/4hc1j2n4
American journal of physiology. Regulatory, integrative and comparative physiology, vol 295, iss 6

The prevalence of type 2 diabetes (T2DM) is increasing, creating a need for T2DM animal models for the study of disease pathogenesis, prevention, and treatment. The purpose of this project was to develop a rat model of T2DM that more closely models t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04bcd9961cf62ad1814961a8d35f3adc
https://doi.org/10.1152/ajpregu.90635.2008

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Role of PI3-kinase–dependent Bad phosphorylation and altered transcription in cytokine-mediated neutrophil survival

Autor: Neda Farahi, Edwin R. Chilvers, Andrew S. Cowburn, Benjamin J. Reed, Karen A. Cadwallader

Publikováno v: Blood. 100:2607-2616

Phosphoinositide 3-kinase (PI3-kinase)-dependent phosphorylation of the proapoptotic Bcl-2 family member Bad has been proposed as an important regulator of apoptotic cell death. To understand the importance of this pathway in nontransformed hematopoi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38662a1767a55536f390ba46a50f2862
https://doi.org/10.1182/blood-2001-11-0122

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Polymers of α1-Antitrypsin Are Chemotactic for Human Neutrophils

Autor: Benjamin J. Reed, Diana Bilton, Karen A. Cadwallader, Edwin R. Chilvers, Ravi Mahadeva, Mary T. Keogan, David A. Lomas, Jasvir Parmar, Neda Farahi

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 26:723-730

Plasma deficiency of alpha(1)-antitrypsin is most commonly due to the Z mutation ((342)Glu--> Lys) and is associated with early-onset panlobular emphysema. The lung disease in these patients is attributed to the relative deficiency of circulating alp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4f1bc431f79f7d0efe1f77ed55ab64
https://doi.org/10.1165/ajrcmb.26.6.4739

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