Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Benjamin J Doranz"'
Autor:
Jay Lubow, Lisa M Levoir, Duncan K Ralph, Laura Belmont, Maya Contreras, Catiana H Cartwright-Acar, Caroline Kikawa, Shruthi Kannan, Edgar Davidson, Veronica Duran, David E Rebellon-Sanchez, Ana M Sanz, Fernando Rosso, Benjamin J Doranz, Shirit Einav, Frederick A Matsen Iv, Leslie Goo
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011722 (2023)
Sequential dengue virus (DENV) infections often generate neutralizing antibodies against all four DENV serotypes and sometimes, Zika virus. Characterizing cross-flavivirus broadly neutralizing antibody (bnAb) responses can inform countermeasures that
Externí odkaz:
https://doaj.org/article/d404a9cd88db4cc6a52805cd6a2a20c6
Autor:
J Charles Whitbeck, Anu Thomas, Kathryn Kadash-Edmondson, Ariadna Grinyo-Escuer, Lewis J Stafford, Celine Cheng, Grant C Liao, Frederick W Holtsberg, M Javad Aman, Graham Simmons, Edgar Davidson, Benjamin J Doranz
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 11, p e0008730 (2020)
The development of vaccines against flaviviruses, including Zika virus (ZIKV) and dengue virus (DENV), continues to be a major challenge, hindered by the lack of efficient and reliable methods for screening neutralizing activity of sera or antibodies
Externí odkaz:
https://doaj.org/article/c7e7952329a2425385d3c09278e4276d
Autor:
Natasha D Durham, Aditi Agrawal, Eric Waltari, Derek Croote, Fabio Zanini, Mallorie Fouch, Edgar Davidson, Olivia Smith, Esteban Carabajal, John E Pak, Benjamin J Doranz, Makeda Robinson, Ana M Sanz, Ludwig L Albornoz, Fernando Rosso, Shirit Einav, Stephen R Quake, Krista M McCutcheon, Leslie Goo
Publikováno v:
eLife, Vol 8 (2019)
Eliciting broadly neutralizing antibodies (bNAbs) against the four dengue virus serotypes (DENV1-4) that are spreading into new territories is an important goal of vaccine design. To define bNAb targets, we characterized 28 antibodies belonging to ex
Externí odkaz:
https://doaj.org/article/ccae0927312e48c899d2a400f15ffaf6
Potent neutralizing antibodies elicited by dengue vaccine in rhesus macaque target diverse epitopes.
Autor:
Leike Li, Weixu Meng, Melanie Horton, Daniel R DiStefano, Elizabeth A Thoryk, Jennifer M Pfaff, Qihui Wang, Georgina T Salazar, Trevor Barnes, Benjamin J Doranz, Andrew J Bett, Danilo R Casimiro, Kalpit A Vora, Zhiqiang An, Ningyan Zhang
Publikováno v:
PLoS Pathogens, Vol 15, Iss 6, p e1007716 (2019)
There is still no safe and effective vaccine against dengue virus infection. Epidemics of dengue virus infection are increasingly a threat to human health around the world. Antibodies generated in response to dengue infection have been shown to impac
Externí odkaz:
https://doaj.org/article/987313e68b584a3482591ce5d30cb479
Autor:
Jarrod J Mousa, Elad Binshtein, Stacey Human, Rachel H Fong, Gabriela Alvarado, Benjamin J Doranz, Martin L Moore, Melanie D Ohi, James E Crowe
Publikováno v:
PLoS Pathogens, Vol 14, Iss 2, p e1006837 (2018)
Respiratory syncytial virus (RSV) is a major human pathogen that infects the majority of children by two years of age. The RSV fusion (F) protein is a primary target of human antibodies, and it has several antigenic regions capable of inducing neutra
Externí odkaz:
https://doaj.org/article/ffc611f2544f42be8d3e1eb19368079d
Autor:
Valentine U Chukwuma, Nurgun Kose, D Noah Sather, Gopal Sapparapu, Rachel Falk, Hannah King, Vidisha Singh, Rebecca Lampley, Delphine C Malherbe, Noah T Ditto, Jonathan T Sullivan, Trevor Barnes, Benjamin J Doranz, Celia C Labranche, David C Montefiori, Spyros A Kalams, Nancy L Haigwood, James E Crowe
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0209437 (2018)
Broadly neutralizing antibodies (bNAbs) are rarely elicited by current human immunodeficiency virus type 1 (HIV-1) vaccine designs, but the presence of bNAbs in naturally infected individuals may be associated with high plasma viral loads, suggesting
Externí odkaz:
https://doaj.org/article/08351d98b2a04c80a58fbe1eddf31c27
Autor:
Radhika Gopal, Kelli Jackson, Netanel Tzarum, Leopold Kong, Andrew Ettenger, Johnathan Guest, Jennifer M Pfaff, Trevor Barnes, Andrew Honda, Erick Giang, Edgar Davidson, Ian A Wilson, Benjamin J Doranz, Mansun Law
Publikováno v:
PLoS Pathogens, Vol 13, Iss 12, p e1006735 (2017)
The hepatitis C virus (HCV) envelope glycoproteins E1 and E2 form a non-covalently linked heterodimer on the viral surface that mediates viral entry. E1, E2 and the heterodimer complex E1E2 are candidate vaccine antigens, but are technically challeng
Externí odkaz:
https://doaj.org/article/5983cfefae904886b7bb6bac3da10a87
Autor:
Mark D Hicar, Xuemin Chen, Chidananda Sulli, Trevor Barnes, Jason Goodman, Hakimuddin Sojar, Bryan Briney, Jordan Willis, Valentine U Chukwuma, Spyros A Kalams, Benjamin J Doranz, Paul Spearman, James E Crowe
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158861 (2016)
Numerous broadly neutralizing antibodies (Abs) target epitopes that are formed or enhanced during mature HIV envelope formation (i.e. quaternary epitopes). Generally, it is thought that Env epitopes that induce broadly neutralizing Abs are difficult
Externí odkaz:
https://doaj.org/article/8d7ec9b26bb547ae8a3d2358b75fda60
Autor:
Suganya Selvarajah, Nicole R Sexton, Kristen M Kahle, Rachel H Fong, Kimberly-Anne Mattia, Joy Gardner, Kai Lu, Nathan M Liss, Beatriz Salvador, David F Tucker, Trevor Barnes, Manu Mabila, Xiangdong Zhou, Giada Rossini, Joseph B Rucker, David Avram Sanders, Andreas Suhrbier, Vittorio Sambri, Alain Michault, Marcus O Muench, Benjamin J Doranz, Graham Simmons
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 9, p e2423 (2013)
The mosquito-borne alphavirus, chikungunya virus (CHIKV), has recently reemerged, producing the largest epidemic ever recorded for this virus, with up to 6.5 million cases of acute and chronic rheumatic disease. There are currently no licensed vaccin
Externí odkaz:
https://doaj.org/article/8169a058b1b3485d96513f63bdd55e09
Autor:
Tiffani A Greene, Suzanne Alarcon, Anu Thomas, Eli Berdougo, Benjamin J Doranz, Paul A S Breslin, Joseph B Rucker
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20123 (2011)
Bitter taste stimuli are detected by a diverse family of G protein-coupled receptors (GPCRs) expressed in gustatory cells. Each bitter taste receptor (TAS2R) responds to an array of compounds, many of which are toxic and can be found in nature. For e
Externí odkaz:
https://doaj.org/article/2cde677a705643af88a4a4ff10c2f7e6