Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Benjamin J Compton"'
Autor:
Anna H. Mooney, Sarah L. Draper, Olivia K. Burn, Regan J. Anderson, Benjamin J. Compton, Chingwen Tang, Kathryn J. Farrand, Pietro Di Lucia, Micol Ravà, Valeria Fumagalli, Leonardo Giustini, Elisa Bono, Dale I. Godfrey, William R. Heath, Weiming Yuan, Francis V. Chisari, Luca G. Guidotti, Matteo Iannacone, John Sidney, Alessandro Sette, Shivali A. Gulab, Gavin F. Painter, Ian F. Hermans
Publikováno v:
JHEP Reports, Vol 6, Iss 5, Pp 101038- (2024)
Background & Aims: Liver diseases resulting from chronic HBV infection are a significant cause of morbidity and mortality. Vaccines that elicit T-cell responses capable of controlling the virus represent a treatment strategy with potential for long-t
Externí odkaz:
https://doaj.org/article/ee2629abc47b4a819f89b5234ea4bfff
Autor:
Theresa E. Pankhurst, Kaitlin H. Buick, Joshua L. Lange, Andrew J. Marshall, Kaileen R. Button, Olga R. Palmer, Kathryn J. Farrand, Isabelle Montgomerie, Thomas W. Bird, Ngarangi C. Mason, Joanna Kuang, Benjamin J. Compton, Davide Comoletti, Mariolina Salio, Vincenzo Cerundolo, Miguel E. Quiñones-Mateu, Gavin F. Painter, Ian F. Hermans, Lisa M. Connor
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112310- (2023)
Summary: Protective immune responses against respiratory pathogens, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are initiated by the mucosal immune system. However, most licensed vaccines are administered
Externí odkaz:
https://doaj.org/article/a3b5f150bb494cd2ab24b2e9cd902159
Autor:
Kef K Prasit, Laura Ferrer-Font, Olivia K Burn, Regan J Anderson, Benjamin J Compton, Alfonso J Schmidt, Johannes U Mayer, Chun-Jen J Chen, Nathaniel Dasyam, David S Ritchie, Dale I Godfrey, Stephen R Mattarollo, P Rod Dunbar, Gavin F Painter, Ian F Hermans
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Intratumoural administration of unmethylated cytosine-phosphate-guanine motifs (CpG) to stimulate toll-like receptor (TLR)-9 has been shown to induce tumour regression in preclinical studies and some efficacy in the clinic. Because activated natural
Externí odkaz:
https://doaj.org/article/423fa268183140eca4c64e8a2ff85aed
Autor:
Roselis A. Landaeta Aponte, Andreas Luxenburger, Scott A. Cameron, Alex Weymouth-Wilson, Richard H. Furneaux, Lawrence D. Harris, Benjamin J. Compton
Publikováno v:
Molecules, Vol 27, Iss 7, p 2364 (2022)
Bile acid receptors have been identified as important targets for the development of new therapeutics to treat various metabolic and inflammatory diseases. The synthesis of new bile acid analogues can help elucidate structure–activity relationships
Externí odkaz:
https://doaj.org/article/2c1d56711d7d4f37b12a93a98705d3c3
Autor:
Katharine Clark, Jessica Yau, Anja Bloom, Jing Wang, David J. Venzon, Motoshi Suzuki, Lise Pasquet, Benjamin J. Compton, Susanna L. Cardell, Steven A. Porcelli, Gavin F. Painter, Dirk M. Zajonc, Jay A. Berzofsky, Masaki Terabe
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
iNKT cells are CD1d-restricted T cells recognizing lipid antigens. The prototypic iNKT cell-agonist α-galactosylceramide (α-GalCer) alongside compounds with similar structures induces robust proliferation and cytokine production of iNKT cells and p
Externí odkaz:
https://doaj.org/article/e95ec8af4f7c4721ac18347afdd733cc
Autor:
Taylor R. Cooney, Kathryn Farrand, Sarah L. Draper, Regan J. Anderson, Phillip M. Rendle, Ian F. Hermans, Benjamin J. Compton, Gavin F. Painter
Publikováno v:
Bioconjugate Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf276d2a5a08b830ef748cdf66c84e1e
https://doi.org/10.1021/acs.bioconjchem.3c00106
https://doi.org/10.1021/acs.bioconjchem.3c00106
Autor:
Michael A. Meijlink, Yu Cheng Chua, Susanna T. S. Chan, Regan J. Anderson, Matthew W. Rosenberg, Anton Cozijnsen, Vanessa Mollard, Geoffrey I. McFadden, Sarah L. Draper, Lauren E. Holz, Ian F. Hermans, William R. Heath, Gavin F. Painter, Benjamin J. Compton
Publikováno v:
RSC Chemical Biology. 3:551-560
Self-adjuvanting vaccines consisting of peptide epitopes conjugated to immune adjuvants are a powerful way of generating antigen-specific immune responses. We previously showed that a Plasmodium-derived peptide conjugated to a rearranged form of α-g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79becbb4d2bba0a25d922032eb9444c7
https://doi.org/10.1039/d1cb00251a
https://doi.org/10.1039/d1cb00251a
Autor:
Theresa E. Pankhurst, Kaitlin H. Buick, Joshua L. Lange, Andrew J. Marshall, Kaileen R. Button, Olga R. Palmer, Kathryn J. Farrand, Isabelle F. N. Stewart, Thomas Bird, Ngarangi C. Mason, Benjamin J. Compton, Davide Comoletti, Mariolina Salio, Vincenzo Cerundolo, Gavin F. Painter, Ian F. Hermans, Lisa M. Connor
Protective immune responses against respiratory pathogens, including influenza virus are initiated by the mucosal immune system. However, most licensed vaccines are administered parenterally and are largely ineffective at inducing mucosal immunity. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffc59a893b8bcba39f1cb73bb5d6cef0
https://doi.org/10.1101/2022.03.31.486638
https://doi.org/10.1101/2022.03.31.486638
Autor:
Andrew MacKenzie, Blake S. Dyer, Jason Ryan, Benjamin J. Compton, Kirill Lagutin, Gavin F. Painter, Eduard V. Nekrasov, Matthew B. Stott, Mikhail Vyssotski
Publikováno v:
Asian Journal of Organic Chemistry. 9:1802-1814
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9139608ac76687af8d7f02450867d299
https://doi.org/10.1002/ajoc.202000357
https://doi.org/10.1002/ajoc.202000357
Autor:
Sage A. Robinson, Gavin F. Painter, Benjamin J. Compton, Masaki Terabe, Jessica Yau, David S. Larsen, Jay A. Berzofsky
Publikováno v:
Org Biomol Chem
The synthesis of the invariant natural killer (iNK) T cell agonist β-mannosylceramide along with a series of fatty amide analogues is reported. Of the six β-glycosylation protocols investigated, the sulfoxide methodology developed by Crich and co-w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23b5b337d0e80e3d0c8de9b77ee4b16
https://doi.org/10.1039/d0ob00223b
https://doi.org/10.1039/d0ob00223b