Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Benjamin J, Wilkins"'
Autor:
Adi Har-Zahav, Ana Tobar, Sophia Fried, Rachel Sivan, Benjamin J. Wilkins, Pierre Russo, Raanan Shamir, Rebecca G. Wells, Michael Gurevich, Orith Waisbourd-Zinman
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Cholangiopathies are poorly understood disorders with no effective therapy. The extrahepatic biliary tree phenotype is less studied compared to the intrahepatic biliary injury in both human disease and Mdr2−/− mice, the established chole
Externí odkaz:
https://doaj.org/article/34c1fd020f514c50a4174d000e53510f
Autor:
Kanak V. Kennedy, MD, Anna Costello, MD, Melissa A. Lerman, MD, PhD, Jon M. Burnham, MD, Aoife Corcoran, MD, Joseph Piccione, DO, Alexandra Grier, MD, PhD, Kathleen Sullivan, MD, PhD, Terri Whitehorn-Brown, MD, Caitlin J. Alexander, MD, Laura S. Finn, MD, Benjamin J. Wilkins, MD, PhD, Amanda B. Muir, MD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 4, Pp 100314- (2024)
We present the first case of a dupilumab-induced hyperinflammatory state in the setting of underlying eosinophilic esophagitis characterized by multisystem granulomatous inflammation. Although clinical trial data and subsequent real-world experience
Externí odkaz:
https://doaj.org/article/f5ab92898c3c4073816864d7097b9d16
Autor:
Rouknuddin Q. Ali, Anne Meyer-Miner, Marie David-Rachel, Fiona J. H. Lee, Benjamin J. Wilkins, Saul J. Karpen, Brian Ciruna, Anand Ghanekar, Binita M. Kamath
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 10 (2023)
Externí odkaz:
https://doaj.org/article/d1572e7bda6548719bb88957e5320cf4
Autor:
Massimo Martinelli, Gabrielle Aguilar, David S.M. Lee, Andrew Kromer, Nhu Nguyen, Benjamin J. Wilkins, Tatiana Akimova, Ulf H. Beier, Louis R. Ghanem
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105860- (2023)
Summary: The RNA-binding protein Pcbp2 is widely expressed in the innate and adaptive immune systems and is essential for mouse development. To determine whether Pcbp2 is required for CD4+ T cell development and function, we derived mice with conditi
Externí odkaz:
https://doaj.org/article/abe9b38a417741fba48e88fa11136c14
Autor:
Peter J. Siska, Jing Jiao, Carina Matos, Katrin Singer, Raffaela S. Berger, Katja Dettmer, Peter J. Oefner, Michelle D. Cully, Zhonglin Wang, William J. QuinnIII, Kristen N. Oliff, Benjamin J. Wilkins, Lanette M. Christensen, Liqing Wang, Wayne W. Hancock, Joseph A. Baur, Matthew H. Levine, Ines Ugele, Roman Mayr, Kathrin Renner, Liang Zhou, Marina Kreutz, Ulf H. Beier
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103734- (2021)
Background: L-kynurenine is a tryptophan-derived immunosuppressive metabolite and precursor to neurotoxic anthranilate and quinolinate. We evaluated the stereoisomer D-kynurenine as an immunosuppressive therapeutic which is hypothesized to produce le
Externí odkaz:
https://doaj.org/article/707b3408191f474680381251d1043115
Autor:
Ting Wang, Jian Liu, Caitlin McDonald, Katherine Lupino, Xiandun Zhai, Benjamin J Wilkins, Hakon Hakonarson, Liming Pei
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 8, Pp 1150-1164 (2017)
Abstract The endocrine system is crucial for maintaining whole‐body homeostasis. Little is known regarding endocrine hormones secreted by the heart other than atrial/brain natriuretic peptides discovered over 30 years ago. Here, we identify growth
Externí odkaz:
https://doaj.org/article/034161167baa44dd9ab5982f6398dfa5
Autor:
Charles H. Danan, Kaitlyn E. Naughton, Katharina E. Hayer, Sangeevan Vellappan, Emily A. McMillan, Yusen Zhou, Rina Matsuda, Shaneice K. Nettleford, Kay Katada, Louis R. Parham, Xianghui Ma, Afrah Chowdhury, Benjamin J. Wilkins, Premal Shah, Matthew D. Weitzman, Kathryn E. Hamilton
Intestinal epithelial transit amplifying cells are essential stem progenitors required for intestinal homeostasis, but their rapid proliferation renders them vulnerable to DNA damage from radiation and chemotherapy. Despite their critical roles in in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6ba4e1d29349598369deb0938fa2c80
https://doi.org/10.1101/2023.04.06.535853
https://doi.org/10.1101/2023.04.06.535853
Autor:
Jonathan Schug, Ayano Kondo, Vivian Ortiz, Siyuan Ma, Michelle Y.Y. Lee, Hongzhe Lee, Daniel Traum, Klaus H. Kaestner, Benjamin J. Wilkins, Natalie A. Terry
Publikováno v:
Gastroenterology
Background & Aims Significant progress has been made since the first report of inflammatory bowel disease (IBD) in 1859, after decades of research that have contributed to the understanding of the genetic and environmental factors involved in IBD pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c551cd9aee757a6d3da86a94a6dc7b6
https://doi.org/10.1053/j.gastro.2021.08.055
https://doi.org/10.1053/j.gastro.2021.08.055
Autor:
Prasanna M Chandramouleeswaran, Dawen Shen, Anna J Lee, Alain Benitez, Kara Dods, Fiona Gambanga, Benjamin J Wilkins, Jamie Merves, Yuliana Noah, Sarit Toltzis, Jennifer H Yearley, Jonathan M Spergel, Hiroshi Nakagawa, Rene deWaal Malefyt, Amanda B Muir, Mei-Lun Wang
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150968 (2016)
Eosinophilic esophagitis (EoE) is a chronic Th2 and food antigen-mediated disease characterized by esophageal eosinophilic infiltration. Thymic stromal lymphopoetin (TSLP), an epithelial derived cytokine which bridges innate and Th2-type adaptive imm
Externí odkaz:
https://doaj.org/article/88cce7a59bc84cd98ad546ff305a0cdb
Publikováno v:
Adv Anat Pathol
Very early-onset inflammatory bowel disease (VEO-IBD), IBD diagnosed in children younger than 6 years old, is phenotypically and genetically distinct from older onset IBD. Monogenic and digenic causative defects, particularly in primary immunodeficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697afe511fd4678da908a63e37cd2204
https://europepmc.org/articles/PMC8665089/
https://europepmc.org/articles/PMC8665089/