Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Benjamin J, Burwitz"'
Autor:
Samuel D. Jeske, Jochen M. Wettengel, Florian Gegenfurtner, Konrad Fischer, Judith Moosmüller, Anindita Chakraborty, Chunkyu Ko, Benjamin J. Burwitz, Angelika Schnieke, Ulrike Protzer
Publikováno v:
npj Viruses, Vol 2, Iss 1, Pp 1-8 (2024)
Abstract With 254 million chronically infected patients, hepatitis B virus (HBV) continues to be a severe health threat. While animal models play a crucial role in developing new therapies, the availability of preclinical HBV models is very limited.
Externí odkaz:
https://doaj.org/article/d6de634fbf1c40c2909bd700f979d1df
Autor:
Jochen M. Wettengel, Hiroaki Naka, Gregory A. Dissen, Jeffrey Torgerson, Michelle Pounder, Simon F. Mueller, Elisabeth Mueller, Philipp Hagen, Micah Brandt, Ulrike Protzer, Benjamin J. Burwitz
Publikováno v:
Vaccines, Vol 12, Iss 2, p 155 (2024)
Adenoviral vectors based on the human adenovirus species C serotype 5 (HAdV-C5) are commonly used for vector-based gene therapies and vaccines. In the preclinical stages of development, their safety and efficacy are often validated in suitable animal
Externí odkaz:
https://doaj.org/article/3b5b1013069f4ea1a754d0ac5ff8ca79
Autor:
Nina Derby, Sreya Biswas, Sofiya Yusova, Cristina Luevano-Santos, Maria Cristina Pacheco, Kimberly A. Meyer, Brooke I. Johnson, Miranda Fischer, Katherine A. Fancher, Cole Fisher, Yohannes M. Abraham, Conor J. McMahon, Savannah S. Lutz, Jeremy V. Smedley, Benjamin J. Burwitz, Donald L. Sodora
Publikováno v:
Viruses, Vol 16, Iss 2, p 296 (2024)
Metabolic-dysfunction-associated fatty liver disease (MAFLD) is a major cause of morbidity and mortality in HIV-infected individuals, even those receiving optimal antiretroviral therapy. Here, we utilized the SIV rhesus macaque model and advanced lap
Externí odkaz:
https://doaj.org/article/cf243f8ab54e4cc8859bf12d3cd45809
Autor:
Junghyun Ryu, John P. Statz, William Chan, Fernanda C. Burch, John V. Brigande, Beth Kempton, Edward V. Porsov, Lauren Renner, Trevor McGill, Benjamin J. Burwitz, Carol B. Hanna, Martha Neuringer, Jon D. Hennebold
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Mutations in the MYO7A gene lead to Usher syndrome type 1B (USH1B), a disease characterized by congenital deafness, vision loss, and balance impairment. To create a nonhuman primate (NHP) USH1B model, CRISPR/Cas9 was used to disrupt MYO7A in
Externí odkaz:
https://doaj.org/article/5a7465c0a8444145a84a6c18f325d2dc
Autor:
Sreya Biswas, Lauren N. Rust, Jochen M. Wettengel, Sofiya Yusova, Miranda Fischer, Julien N. Carson, Josie Johnson, Lei Wei, Trason Thode, Mohan R. Kaadige, Sunil Sharma, Majd Agbaria, Benjamin N. Bimber, Thomas Tu, Ulrike Protzer, Alexander Ploss, Jeremy V. Smedley, Gershon Golomb, Jonah B. Sacha, Benjamin J. Burwitz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Here, Biswas et al. present and characterize a second-generation model of HBV infection in rhesus macaques, showing that extended infection requires suppression of host immunity.
Externí odkaz:
https://doaj.org/article/6626a89b33b1442db7ec196681607c1f
Autor:
Junghyun Ryu, William Chan, Jochen M. Wettengel, Carol B. Hanna, Benjamin J. Burwitz, Jon D. Hennebold, Benjamin N. Bimber
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 241-254 (2022)
Genome engineering is a powerful tool for in vitro research and the creation of novel model organisms and has growing clinical applications. Randomly integrating vectors, such as lentivirus- or transposase-based methods, are simple and easy to use bu
Externí odkaz:
https://doaj.org/article/5ca17975b64d41049a0eb0d7fe151108
Autor:
Bridget S. Fisher, Katherine A. Fancher, Andrew T. Gustin, Cole Fisher, Matthew P. Wood, Michael Gale, Benjamin J. Burwitz, Jeremy Smedley, Nichole R. Klatt, Nina Derby, Donald L. Sodora
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Liver disease is a significant contributor to morbidity and mortality in HIV-infected individuals, even during successful viral suppression with combination antiretroviral therapy (cART). Similar to HIV infection, SIV infection of rhesus macaques is
Externí odkaz:
https://doaj.org/article/d73c35822bd84408890f4f50ab8f6716
Autor:
Suhas Sureshchandra, Chi N. Chan, Jacob J. Robino, Lindsay K. Parmelee, Michael J. Nash, Stephanie R. Wesolowski, Eric M. Pietras, Jacob E. Friedman, Diana Takahashi, Weining Shen, Xiwen Jiang, Jon D. Hennebold, Devorah Goldman, William Packwood, Jonathan R. Lindner, Charles T. Roberts, Benjamin J. Burwitz, Ilhem Messaoudi, Oleg Varlamov
Publikováno v:
Stem Cell Reports. 17:2595-2609
Maternal obesity adversely impacts the in utero metabolic environment, but its effect on fetal hematopoiesis remains incompletely understood. During late development, the fetal bone marrow (FBM) becomes the major site where macrophages and B lymphocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d95d9238fc5f4baa9c3d2b6867dfa8
https://doi.org/10.1016/j.stemcr.2022.10.003
https://doi.org/10.1016/j.stemcr.2022.10.003
Autor:
Helen L. Wu, Whitney Weber, Shaheed A. Abdulhaqq, Christine Shriver-Munsch, Tonya Swanson, Mina Northrup, Kimberly Armantrout, Heidi Price, Mitchell Robertson-LeVay, Jason S. Reed, Katherine B. Bateman, Benjamin N. Bimber, Stephanie L. Junell, Rhonda MacAllister, Alfred W. Legasse, Michael K. Axthelm, Cassandra Moats, Jeremy Smedley, Theodore R. Hobbs, Lauren D. Martin, Gabrielle Meyers, Richard T. Maziarz, Benjamin J. Burwitz, Jeffrey J. Stanton, Jonah B. Sacha
Publikováno v:
Journal of Virus Eradication, Vol 5, Iss , Pp 19- (2019)
Externí odkaz:
https://doaj.org/article/aa992c8462d9478f90e5cf5c5077def3
Autor:
Benjamin J. Burwitz, Jochen M. Wettengel, Martin A. Mück-Häusl, Marc Ringelhan, Chunkyu Ko, Marvin M. Festag, Katherine B. Hammond, Mina Northrup, Benjamin N. Bimber, Thomas Jacob, Jason S. Reed, Reed Norris, Byung Park, Sven Moller-Tank, Knud Esser, Justin M. Greene, Helen L. Wu, Shaheed Abdulhaqq, Gabriela Webb, William F. Sutton, Alex Klug, Tonya Swanson, Alfred W. Legasse, Tania Q. Vu, Aravind Asokan, Nancy L. Haigwood, Ulrike Protzer, Jonah B. Sacha
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Hepatitis B virus (HBV) has a limited host range and current animal models can only recapitulate certain aspects of HBV replication. Here, the authors show that expression of the HBV receptor NTCP in macaques supports HBV replication in vivo, suggest
Externí odkaz:
https://doaj.org/article/2039d96647514d3c9a3deb587404ab5a