Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Benjamin J, Burke"'
Autor:
Alice T. Shaw, Aaron N. Hata, Ted W. Johnson, Jeffrey A. Engelman, Mari Mino-Kenudson, Jochen K. Lennerz, Cyril H. Benes, A. John Iafrate, Rebecca S. Heist, Daria Timonina, Krystina E. Kattermann, Amanda K. Riley, Lorin A. Ferris, Justin F. Gainor, Harper Hubbeling, Sergei Timofeevski, Ibiayi Dagogo-Jack, Kylie Prutisto-Chang, Leila Dardaei, Adam Langenbucher, Luc Friboulet, Benjamin J. Burke, Michael S. Lawrence, Jessica J. Lin, Satoshi Yoda
suppl tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695e64cddb17425642cdd97e3a2d9049
https://doi.org/10.1158/2159-8290.22532569
https://doi.org/10.1158/2159-8290.22532569
Autor:
Alice T. Shaw, Aaron N. Hata, Ted W. Johnson, Jeffrey A. Engelman, Mari Mino-Kenudson, Jochen K. Lennerz, Cyril H. Benes, A. John Iafrate, Rebecca S. Heist, Daria Timonina, Krystina E. Kattermann, Amanda K. Riley, Lorin A. Ferris, Justin F. Gainor, Harper Hubbeling, Sergei Timofeevski, Ibiayi Dagogo-Jack, Kylie Prutisto-Chang, Leila Dardaei, Adam Langenbucher, Luc Friboulet, Benjamin J. Burke, Michael S. Lawrence, Jessica J. Lin, Satoshi Yoda
Supplementary Methods include Enzyme Kinetic Assays and Computational Methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c2a51cb420c3360802ceddf3bd3129
https://doi.org/10.1158/2159-8290.22532572
https://doi.org/10.1158/2159-8290.22532572
Autor:
Alice T. Shaw, Aaron N. Hata, Ted W. Johnson, Jeffrey A. Engelman, Mari Mino-Kenudson, Jochen K. Lennerz, Cyril H. Benes, A. John Iafrate, Rebecca S. Heist, Daria Timonina, Krystina E. Kattermann, Amanda K. Riley, Lorin A. Ferris, Justin F. Gainor, Harper Hubbeling, Sergei Timofeevski, Ibiayi Dagogo-Jack, Kylie Prutisto-Chang, Leila Dardaei, Adam Langenbucher, Luc Friboulet, Benjamin J. Burke, Michael S. Lawrence, Jessica J. Lin, Satoshi Yoda
Supplementary Figures include Figure S1-S9.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41fad9679c55dabdcc8b3f00fc268e3f
https://doi.org/10.1158/2159-8290.22532575
https://doi.org/10.1158/2159-8290.22532575
Autor:
Paul G. Richardson, Xiaoyun Meng, Karen A. Maegley, A.E. Stewart, Pei-Pei Kung, Jose L Montano, Ya-Li Deng, Jinqiao Wan, Michael R. Gehring, Jordan L. Meier, Brigitte S Naughton, Stephan Grant, Dou Dengfeng, Chakrapani Subramanyam, Anthony R. Harris, Samantha Elizabeth Greasley, Barry A. Morgan, Wen Yan, Xuemin Cheng, Prakash B. Palde, William K Sonnenburg, Junli Feng, Chen Qiuxia, Thomas A Paul, Gary M. Gallego, Sylvie K. Sakata, Sergei Timofeevski, Patrick Bingham, Benjamin J. Burke, Alex Shaginian
Publikováno v:
ACS Med Chem Lett
[Image: see text] Two novel compounds were identified as Naa50 binders/inhibitors using DNA-encoded technology screening. Biophysical and biochemical data as well as cocrystal structures were obtained for both compounds (3a and 4a) to understand thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0b93599ae79500f98919ddfa6e48aa
https://doi.org/10.1021/acsmedchemlett.0c00029
https://doi.org/10.1021/acsmedchemlett.0c00029
Autor:
Jin-Xin, Zhao, Yu-Xuan, Chang, Chi, He, Benjamin J, Burke, Michael R, Collins, Matthew, Del Bel, Jeff, Elleraas, Gary M, Gallego, T Patrick, Montgomery, James J, Mousseau, Sajiv K, Nair, Matthew A, Perry, Jillian E, Spangler, Julien C, Vantourout, Phil S, Baran
Publikováno v:
Proc Natl Acad Sci U S A
The development of a versatile platform for the synthesis of 1,2-difunctionalized bicyclo[1.1.1]pentanes to potentially mimic ortho/meta-substituted arenes is described. The syntheses of useful building blocks bearing alcohol, amine, and carboxylic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be474420b18a4b45fea8036f2e5c0147
https://pubmed.ncbi.nlm.nih.gov/34244445
https://pubmed.ncbi.nlm.nih.gov/34244445
Autor:
Phil S. Baran, Matthew Del Bel, Gary M. Gallego, Michael R. Collins, Matthew A. Perry, Jin-Xin Zhao, Sajiv Krishnan Nair, Yu-Xuan Chang, Benjamin J. Burke, T Patrick Montgomery, Jeff Elleraas, James J. Mousseau, Chi He, Julien C. Vantourout, Jillian E. Spangler
Publikováno v:
Proceedings of the National Academy of Sciences. 118
The development of a versatile platform for the synthesis of 1,2-difunctionalized bicyclo[1.1.1]pentanes to potentially mimic ortho/meta-substituted arenes is described. The syntheses of useful building blocks bearing alcohol, amine, and carboxylic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fd8f190bb06c73312821b742431a453
https://doi.org/10.1073/pnas.2108881118
https://doi.org/10.1073/pnas.2108881118
Autor:
Alice T. Shaw, Luc Friboulet, Daria Timonina, Benjamin J. Burke, Krystina E. Kattermann, Justin F. Gainor, Jeffrey A. Engelman, Amanda K. Riley, A. John Iafrate, Jochen K. Lennerz, Adam Langenbucher, Sergei Timofeevski, Aaron N. Hata, Leila Dardaei, Cyril H. Benes, Lorin A. Ferris, Jessica J. Lin, Kylie Prutisto-Chang, Ted William Johnson, Harper Hubbeling, Rebecca S. Heist, Ibiayi Dagogo-Jack, Mari Mino-Kenudson, Satoshi Yoda, Michael S. Lawrence
Publikováno v:
Cancer Discovery
The cornerstone of treatment for advanced ALK-positive lung cancer is sequential therapy with increasingly potent and selective ALK inhibitors. The third-generation ALK inhibitor lorlatinib has demonstrated clinical activity in patients who failed pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc9dd4ab55a0ede980f9605e74b91f8
Autor:
Paul G. Richardson, Phuong Le, Benjamin J. Burke, Ted William Johnson, Sacha Ninkovic, Ketan S. Gajiwala, Maria Angelica Linton
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:3408-3413
Incorporation of nitrogen is a common medicinal chemistry tactic to reduce log D values. Neighboring group participation influences log D , so the results are isomer dependent. The log D and log P differences observed between isomeric pyrimidines 1 ,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658c49747fb24d27934733c69e9c1fce
https://doi.org/10.1016/j.bmc.2015.04.041
https://doi.org/10.1016/j.bmc.2015.04.041
Autor:
Sergei Timofeevski, Lars D. Engstrom, Mingying He, Michael R. Collins, Martin Paul Edwards, Phuong Le, Graham L. Smith, John Charles Kath, Helen Y. Zou, Deal Judith G, Ya-Li Deng, Robert Steven Kania, Benjamin J. Burke, Cynthia Louise Palmer, Huichun Zhu, A.E. Stewart, Hieu Lam, Dac M. Dinh, Simon Bailey, Jacqui Elizabeth Hoffman, Neal W. Sach, Robert Louis Hoffman, Qinhua Huang, J. Jean Cui, Alexei Brooun, Wei Liu, Laura Lingardo, Tod Smeal, Ted William Johnson, Michele McTigue, Justine L. Lam, Jinjiang Zhu, Paul F. Richardson
Publikováno v:
Journal of Medicinal Chemistry. 57:4720-4744
Although crizotinib demonstrates robust efficacy in anaplastic lymphoma kinase (ALK)-positive non-small-cell lung carcinoma patients, progression during treatment eventually develops. Resistant patient samples revealed a variety of point mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a88513bc93ec9da81fd3688f6b55fb99
https://doi.org/10.1021/jm500261q
https://doi.org/10.1021/jm500261q
Autor:
Tod Smeal, Wei Liu, Huichun Zhu, Simon Bailey, Michael R. Collins, A.E. Stewart, Jacqui Elizabeth Hoffman, Lars D. Engstrom, Graham L. Smith, J. Jean Cui, Ya-Li Deng, Benjamin J. Burke, Laura Lingardo, Phuong Le, Andrew Simon Cook, Konstantinos Tsaparikos, Hieu Lam, Jinjiang Zhu, Ted William Johnson, Neal W. Sach, Dac M. Dinh, Robert Louis Hoffman, Mingying He, Hui Wang, Alexei Brooun, Dack Kevin Neil, Qinhua Huang, Sergei Timofeevski, Deal Judith G, Justine L. Lam, Qiuhua Li, Hong Shen, Melissa West Lu, Michele McTigue, Paul F. Richardson, Kevin D. Bunker, Robert Steven Kania, Martin Paul Edwards, Helen Y. Zou, Cynthia Louise Palmer, Patrick S. Johnson
Publikováno v:
Journal of Medicinal Chemistry. 57:1170-1187
Crizotinib (1), an anaplastic lymphoma kinase (ALK) receptor tyrosine kinase inhibitor approved by the U.S. Food and Drug Administration in 2011, is efficacious in ALK and ROS positive patients. Under pressure of crizotinib treatment, point mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f25cdb3a3b4202005c75976a5f6a5ac
https://doi.org/10.1021/jm401805h
https://doi.org/10.1021/jm401805h