Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Benjamin J, Buckley"'
Autor:
Kiel Hards, Chen-Yi Cheung, Natalie Waller, Cara Adolph, Laura Keighley, Zhi Shean Tee, Liam K. Harold, Ayana Menorca, Richard S. Bujaroski, Benjamin J. Buckley, Joel D. A. Tyndall, Matthew B. McNeil, Kyu Y. Rhee, Helen K. Opel-Reading, Kurt Krause, Laura Preiss, Julian D. Langer, Thomas Meier, Erik J. Hasenoehrl, Michael Berney, Michael J. Kelso, Gregory M. Cook
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Derivatives of the FDA-approved drug, amiloride, can eliminate drug-resistant Mycobacterium tuberculosis in vitro by interfering with bacterial energy conservation.
Externí odkaz:
https://doaj.org/article/dae3bf53428948ca8c7fbb2eb80c8d45
Autor:
Kiem Vu, Benjamin J. Buckley, Richard S. Bujaroski, Eduardo Blumwald, Michael J. Kelso, Angie Gelli
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Fungal infections have become an increasing threat as a result of growing numbers of susceptible hosts and diminishing effectiveness of antifungal drugs due to multi-drug resistance. This reality underscores the need to develop novel drugs with uniqu
Externí odkaz:
https://doaj.org/article/9f2a367dfa99493b98e4fd848a7e2a1a
Autor:
S. M. Zahid Hosen, Md. Nazim Uddin, Zhihong Xu, Benjamin J. Buckley, Chamini Perera, Tony C. Y. Pang, Alpha Raj Mekapogu, Mohammad Ali Moni, Faiyaz Notta, Steven Gallinger, Ron Pirola, Jeremy Wilson, Marie Ranson, David Goldstein, Minoti Apte
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundPrevious studies have revealed the role of dysregulated urokinase plasminogen activator (encoded by PLAU) expression and activity in several pathways associated with cancer progression. However, systematic investigation into the association
Externí odkaz:
https://doaj.org/article/389f362a1ff54af2905c59882ec6c0e9
Autor:
Peter Cuthbertson, Amal Elhage, Dena Al-Rifai, Reece A. Sophocleous, Ross J. Turner, Ashraf Aboelela, Hiwa Majed, Richard S. Bujaroski, Iman Jalilian, Michael J. Kelso, Debbie Watson, Benjamin J. Buckley, Ronald Sluyter
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1309 (2022)
P2X7 is an extracellular adenosine 5′-triphopshate (ATP)-gated cation channel present on leukocytes, where its activation induces pro-inflammatory cytokine release and ectodomain shedding of cell surface molecules. Human P2X7 can be partially inhib
Externí odkaz:
https://doaj.org/article/ec5409f7111249ca998740badc225245
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 152 (2022)
Pancreatic cancer is a highly aggressive malignancy that features high recurrence rates and the poorest prognosis of all solid cancers. The urokinase plasminogen activation system (uPAS) is strongly implicated in the pathophysiology and clinical outc
Externí odkaz:
https://doaj.org/article/cb3a6ece27454a24b820ae7b7892de1f
Autor:
Mingdong Huang, Haibo Yu, Longguang Jiang, Nehad El Salamouni, Benjamin J. Buckley, Michael J. Kelso, Marie Ranson
Publikováno v:
Journal of Medicinal Chemistry. 65:1933-1945
The urokinase plasminogen activator (uPA) plays a critical role in tumor cell invasion and migration and is a promising anti-metastasis target. 6-Substituted analogs of 5-N,N-(hexamethylene)amiloride (HMA) are potent and selective uPA inhibitors that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28578fa6df87bf80a576f693c3b6d1b3
https://doi.org/10.1021/acs.jmedchem.1c01423
https://doi.org/10.1021/acs.jmedchem.1c01423
Autor:
Rocio K. Finol-Urdaneta, Jeffrey R. McArthur, Ashraf Aboelela, Richard S. Bujaroski, Hiwa Majed, Alejandra Rangel, David J. Adams, Marie Ranson, Michael J. Kelso, Benjamin J. Buckley
Acid-sensing ion channels (ASICs) are transmembrane sensors of extracellular acidosis and potential drug targets in several disease indications, including neuropathic pain and cancer metastasis. The K+-sparing diuretic amiloride is a moderate non-spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dba14ffe5766c44ccd30f35396253dd5
https://doi.org/10.1101/2022.03.12.484055
https://doi.org/10.1101/2022.03.12.484055
Publikováno v:
Biophys Rev
The urokinase plasminogen activator (uPA) is a widely studied anticancer drug target with multiple classes of inhibitors reported to date. Many of these inhibitors contain amidine or guanidine groups, while others lacking these groups show improved o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51637536842508fa7e9310e77faa6928
https://doi.org/10.31219/osf.io/3z5m4
https://doi.org/10.31219/osf.io/3z5m4
Autor:
Kiel, Hards, Chen-Yi, Cheung, Natalie, Waller, Cara, Adolph, Laura, Keighley, Zhi Shean, Tee, Liam K, Harold, Ayana, Menorca, Richard S, Bujaroski, Benjamin J, Buckley, Joel D A, Tyndall, Matthew B, McNeil, Kyu Y, Rhee, Helen K, Opel-Reading, Kurt, Krause, Laura, Preiss, Julian D, Langer, Thomas, Meier, Erik J, Hasenoehrl, Michael, Berney, Michael J, Kelso, Gregory M, Cook
Publikováno v:
Communications biology. 5(1)
Increasing antimicrobial resistance compels the search for next-generation inhibitors with differing or multiple molecular targets. In this regard, energy conservation in Mycobacterium tuberculosis has been clinically validated as a promising new dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::27d4818343c40ab81f2a54807685303c
https://pubmed.ncbi.nlm.nih.gov/35210534
https://pubmed.ncbi.nlm.nih.gov/35210534
Publikováno v:
Current Drug Targets
Rheumatoid arthritis (RA) is a chronic and progressive inflammatory disease characterized in its early stages by synovial hyperplasia and inflammatory cell infiltration and later by irreversible joint tissue destruction. The plasminogen activation sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297a4e269e02658da3ae3458a62b772b
https://doi.org/10.2174/1389450120666181204164140
https://doi.org/10.2174/1389450120666181204164140