Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Benjamin Israelow"'
Autor:
Min Zhao, Pei-Yi Su, Danielle A Castro, Therese N Tripler, Yingxia Hu, Matthew Cook, Albert I Ko, Shelli F Farhadian, Benjamin Israelow, Charles S Dela Cruz, Yong Xiong, Richard E Sutton, Yale IMPACT Research Team
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009683 (2021)
COVID-19 is a global crisis of unimagined dimensions. Currently, Remedesivir is only fully licensed FDA therapeutic. A major target of the vaccine effort is the SARS-CoV-2 spike-hACE2 interaction, and assessment of efficacy relies on time consuming n
Externí odkaz:
https://doaj.org/article/b2383cfe0cfb49c9beaf80ad8a7fdffc
Autor:
Eriko Kudo, Benjamin Israelow, Chantal B F Vogels, Peiwen Lu, Anne L Wyllie, Maria Tokuyama, Arvind Venkataraman, Doug E Brackney, Isabel M Ott, Mary E Petrone, Rebecca Earnest, Sarah Lapidus, M Catherine Muenker, Adam J Moore, Arnau Casanovas-Massana, Yale IMPACT Research Team, Saad B Omer, Charles S Dela Cruz, Shelli F Farhadian, Albert I Ko, Nathan D Grubaugh, Akiko Iwasaki
Publikováno v:
PLoS Biology, Vol 18, Iss 10, p e3000867 (2020)
The current quantitative reverse transcription PCR (RT-qPCR) assay recommended for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing in the United States requires analysis of 3 genomic targets per sample: 2 viral and 1 host. To sim
Externí odkaz:
https://doaj.org/article/5019bd8fc4174e7b8f0a09373261a311
Autor:
Jonathan K. Mitchell, Bentley R. Midkiff, Benjamin Israelow, Matthew J. Evans, Robert E. Lanford, Christopher M. Walker, Stanley M. Lemon, David R. McGivern
Publikováno v:
mBio, Vol 8, Iss 2 (2017)
ABSTRACT Many DNA tumor viruses promote cellular transformation by inactivating the critically important tumor suppressor protein p53. In contrast, it is not known whether p53 function is disrupted by hepatitis C virus (HCV), a unique, oncogenic RNA
Externí odkaz:
https://doaj.org/article/9c7aab5b79d24bc7ab1c2afe955f3b68
Autor:
Sharon E. Hopcraft, Kristopher D. Azarm, Benjamin Israelow, Nicolas Lévêque, Megan C. Schwarz, Tien-Huei Hsu, Matthew T. Chambers, Marion Sourisseau, Bert L. Semler, Matthew J. Evans
Publikováno v:
mSphere, Vol 1, Iss 1 (2016)
ABSTRACT Hepatitis C virus (HCV) replication requires binding of the liver-specific microRNA (miRNA) miR-122 to two sites in the HCV 5′ untranslated region (UTR). Although we and others have shown that viral genetics impact the amount of active miR
Externí odkaz:
https://doaj.org/article/ef738360aa8246348fe99a4903d25002
Autor:
Marion Sourisseau, Maria L Michta, Chati Zony, Benjamin Israelow, Sharon E Hopcraft, Christopher M Narbus, Ana Parra Martín, Matthew J Evans
Publikováno v:
PLoS Pathogens, Vol 9, Iss 3, p e1003244 (2013)
Hepatitis C virus (HCV) is a major cause of liver disease worldwide. A better understanding of its life cycle, including the process of host cell entry, is important for the development of HCV therapies and model systems. Based on the requirement for
Externí odkaz:
https://doaj.org/article/1e10932f751e49cfa4eaa21b4bf0fc42
Autor:
Manik, Kuchroo, Jessie, Huang, Patrick, Wong, Jean-Christophe, Grenier, Dennis, Shung, Alexander, Tong, Carolina, Lucas, Jon, Klein, Daniel B, Burkhardt, Scott, Gigante, Abhinav, Godavarthi, Bastian, Rieck, Benjamin, Israelow, Michael, Simonov, Tianyang, Mao, Ji Eun, Oh, Julio, Silva, Takehiro, Takahashi, Camila D, Odio, Arnau, Casanovas-Massana, John, Fournier, Shelli, Farhadian, Charles S, Dela Cruz, Albert I, Ko, Matthew J, Hirn, F Perry, Wilson, Julie G, Hussin, Guy, Wolf, Akiko, Iwasaki, Yvette, Strong
Publikováno v:
Nat Biotechnol
As the biomedical community produces datasets that are increasingly complex and high dimensional, there is a need for more sophisticated computational tools to extract biological insights. We present Multiscale PHATE, a method that sweeps through all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbc7b5d57e7a395fabb6caf9bc63a6a
https://doi.org/10.1038/s41587-021-01186-x
https://doi.org/10.1038/s41587-021-01186-x
Autor:
Tianyang Mao, Benjamin Israelow, Mario A. Peña-Hernández, Alexandra Suberi, Liqun Zhou, Sophia Luyten, Melanie Reschke, Huiping Dong, Robert J. Homer, W. Mark Saltzman, Akiko Iwasaki
Publikováno v:
Science (New York, N.Y.). 378(6622)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has highlighted the need for vaccines that not only prevent disease but also prevent transmission. Parenteral vaccines induce robust systemic immunity but poor immunity at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4cc222314008b7dd881bf92fe48c9ca
https://pubmed.ncbi.nlm.nih.gov/35118464
https://pubmed.ncbi.nlm.nih.gov/35118464
Autor:
Mary E. Petrone, Carolina Lucas, Shelli F. Farhadian, Isabel M. Ott, Emily S. Perotti, Wade L. Schulz, Charles S. Dela Cruz, Chantal B.F. Vogels, Ji Eun Oh, Neil S Zheng, Anne L. Wyllie, Jillian R. Jaycox, Yile Dai, Anne E. Watkins, Suzanne Fischer, Nathan D. Grubaugh, Jon Klein, Eric Wang, Aaron M. Ring, Tianyang Mao, Patrick Wong, Akiko Iwasaki, Chaney C. Kalinich, Feimei Liu, Ting Zhou, Julio Silva, Benjamin Israelow, John Fournier, Andreas Coppi, Shuangge Ma, Albert I. Ko, Melissa Campbell, John D. Huck, Eric Song
Publikováno v:
Nature. 595:283-288
COVID-19 manifests with a wide spectrum of clinical phenotypes that are characterized by exaggerated and misdirected host immune responses1-6. Although pathological innate immune activation is well-documented in severe disease1, the effect of autoant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::586128b7c6fff422327dbc915b5098dc
https://doi.org/10.1038/s41586-021-03631-y
https://doi.org/10.1038/s41586-021-03631-y
Autor:
Alexandra Suberi, Molly K. Grun, Tianyang Mao, Benjamin Israelow, Melanie Reschke, Julian Grundler, Laiba Akhtar, Teresa Lee, Kwangsoo Shin, Alexandra S. Piotrowski-Daspit, Robert J. Homer, Akiko Iwasaki, Hee Won Suh, W. Mark Saltzman
Publikováno v:
bioRxiv
An inhalable platform for mRNA therapeutics would enable minimally invasive and lung targeted delivery for a host of pulmonary diseases. Development of lung targeted mRNA therapeutics has been limited by poor transfection efficiency and risk of vehic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ba54aaf5252c0c6fbc146741fa0938
https://doi.org/10.1101/2022.03.22.485401
https://doi.org/10.1101/2022.03.22.485401
Autor:
Jennifer S. Chen, Ryan D. Chow, Eric Song, Tianyang Mao, Benjamin Israelow, Kathy Kamath, Joel Bozekowski, Winston A. Haynes, Renata B. Filler, Bridget L. Menasche, Jin Wei, Mia Madel Alfajaro, Wenzhi Song, Lei Peng, Lauren Carter, Jason S. Weinstein, Uthaman Gowthaman, Sidi Chen, Joe Craft, John C. Shon, Akiko Iwasaki, Craig B. Wilen, Stephanie C. Eisenbarth
Publikováno v:
Sci Immunol
T follicular helper (T FH ) cells are the conventional drivers of protective, germinal center (GC)–based antiviral antibody responses. However, loss of T FH cells and GCs has been observed in patients with severe COVID-19. As T cell–B cell intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4679d3da996c3e8b8ea5b4b7075eb96
https://doi.org/10.1126/sciimmunol.abl5652
https://doi.org/10.1126/sciimmunol.abl5652