Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Benjamin I . Laufer"'
Autor:
Julia S. Mouat, Shaobo Li, Swe Swe Myint, Benjamin I. Laufer, Philip J. Lupo, Jeremy M. Schraw, John P. Woodhouse, Adam J. de Smith, Janine M. LaSalle
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-18 (2023)
Abstract Background Congenital heart defects (CHDs) affect approximately half of individuals with Down syndrome (DS), but the molecular reasons for incomplete penetrance are unknown. Previous studies have largely focused on identifying genetic risk f
Externí odkaz:
https://doaj.org/article/7d8ab561956d4e7a86e1153a556c2027
Autor:
Amy E. Byrnes, Sara L. Dominguez, Chun-Wan Yen, Benjamin I. Laufer, Oded Foreman, Mike Reichelt, Han Lin, Meredith Sagolla, Kathy Hötzel, Hai Ngu, Christoffer Soendergaard, Alberto Estevez, Hsiu-Chao Lin, Alexandre Goyon, Juan Bian, Jessica Lin, Flora I. Hinz, Brad A. Friedman, Amy Easton, Casper C. Hoogenraad
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 773-793 (2023)
Antisense oligonucleotide (ASO) therapeutics are being investigated for a broad range of neurological diseases. While ASOs have been effective in the clinic, improving productive ASO internalization into target cells remains a key area of focus in th
Externí odkaz:
https://doaj.org/article/3689714968e4460891db8a383fa60cf7
Autor:
Min Jung, Michelle Dourado, James Maksymetz, Amanda Jacobson, Benjamin I. Laufer, Miriam Baca, Oded Foreman, David H. Hackos, Lorena Riol-Blanco, Joshua S. Kaminker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Sensory neurons are critical for maintaining tissue homeostasis. Here, the authors generated a single-nuclei cross-species atlas of the dorsal root ganglia, revealing conserved programs for sensory function that could inform therapeutic hypotheses.
Externí odkaz:
https://doaj.org/article/45364aef1d7b4294b20a95c973a19812
Autor:
Benjamin I. Laufer, Yu Hasegawa, Zhichao Zhang, Casey E. Hogrefe, Laura A. Del Rosso, Lori Haapanen, Hyeyeon Hwang, Melissa D. Bauman, Judy Van de Water, Ameer Y. Taha, Carolyn M. Slupsky, Mari S. Golub, John P. Capitanio, Catherine A. VandeVoort, Cheryl K. Walker, Janine M. LaSalle
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
In animal models, maternal obesity is associated with development of neurodevelopmental disorder like phenotypes. Here the authors show in a macaque model that in obese dams, cell-free fetal DNA methylation, inflammatory cytokines, and metabolites co
Externí odkaz:
https://doaj.org/article/bfda17b385eb45c399ddcbf0d2cffdd0
Autor:
Yihui Zhu, J. Antonio Gomez, Benjamin I. Laufer, Charles E. Mordaunt, Julia S. Mouat, Daniela C. Soto, Megan Y. Dennis, Kelly S. Benke, Kelly M. Bakulski, John Dou, Ria Marathe, Julia M. Jianu, Logan A. Williams, Orangel J. Gutierrez Fugón, Cheryl K. Walker, Sally Ozonoff, Jason Daniels, Luke P. Grosvenor, Heather E. Volk, Jason I. Feinberg, M. Daniele Fallin, Irva Hertz-Picciotto, Rebecca J. Schmidt, Dag H. Yasui, Janine M. LaSalle
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-32 (2022)
Abstract Background Autism spectrum disorder (ASD) involves complex genetics interacting with the perinatal environment, complicating the discovery of common genetic risk. The epigenetic layer of DNA methylation shows dynamic developmental changes an
Externí odkaz:
https://doaj.org/article/f6d35ff30916481bbb358c37ec11e956
Autor:
Angela G. Maggio, Henry T. Shu, Benjamin I. Laufer, Chongfeng Bi, Yinglei Lai, Janine M. LaSalle, Valerie W. Hu
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Environmental exposures to endocrine disrupting compounds (EDCs) such as the organochlorines have been linked with various diseases including neurodevelopmental disorders. Autism spectrum disorder (ASD) is a highly complex neurodevelopmental disorder
Externí odkaz:
https://doaj.org/article/4049fdc39ba74dbcb2ae582372ba4402
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-15 (2021)
Abstract Background Down syndrome (DS) is characterized by a genome-wide profile of differential DNA methylation that is skewed towards hypermethylation in most tissues, including brain, and includes pan-tissue differential methylation. The molecular
Externí odkaz:
https://doaj.org/article/e4bb9bad6e9843408caa47e3062cf23a
Autor:
Charles E. Mordaunt, Julia M. Jianu, Benjamin I. Laufer, Yihui Zhu, Hyeyeon Hwang, Keith W. Dunaway, Kelly M. Bakulski, Jason I. Feinberg, Heather E. Volk, Kristen Lyall, Lisa A. Croen, Craig J. Newschaffer, Sally Ozonoff, Irva Hertz-Picciotto, M. Daniele Fallin, Rebecca J. Schmidt, Janine M. LaSalle
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-25 (2020)
Abstract Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex heritability and higher prevalence in males. The neonatal epigenome has the potential to reflect past interactions between genetic and environmental fact
Externí odkaz:
https://doaj.org/article/5daab9d3cbe4415ca5f185f325d2a213
Publikováno v:
Environment International, Vol 158, Iss , Pp 106993- (2022)
Background: Wildfire smoke is responsible for around 20% of all particulate emissions in the U.S. and affects millions of people worldwide. Children are especially vulnerable, as ambient air pollution exposure during early childhood is associated wit
Externí odkaz:
https://doaj.org/article/77cc765134bf4124830d3738f9a98a99
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Neurodevelopment in humans is a long, elaborate, and highly coordinated process involving three trimesters of prenatal development followed by decades of postnatal development and maturation. Throughout this period, the brain is highly sensitive and
Externí odkaz:
https://doaj.org/article/d05b466a8b6c4416981a142196e13d3a