Fluorine-18-Labeled Fluorescent Dyes for Dual-Mode Molecular Imaging

Autor: Maxime Munch, Benjamin H. Rotstein, Gilles Ulrich

Publikováno v: Molecules, Vol 25, Iss 24, p 6042 (2020)

Recent progress realized in the development of optical imaging (OPI) probes and devices has made this technique more and more affordable for imaging studies and fluorescence-guided surgery procedures. However, this imaging modality still suffers from

Externí odkaz: https://doaj.org/article/cc2c5ad1bbd346deac290d9cfcf4ac68

Preclinical PET Neuroimaging of [C]Bexarotene

Autor: Benjamin H. Rotstein PhD, Michael S. Placzek PhD, Hema S. Krishnan PhD, Aleksandra Pekošak MPharm, Thomas Lee Collier PhD, Changning Wang PhD, Steven H. Liang PhD, Ethan S. Burstein PhD, Jacob M. Hooker PhD, Neil Vasdev PhD

Publikováno v: Molecular Imaging, Vol 15 (2016)

Activation of retinoid X receptors (RXRs) has been proposed as a therapeutic mechanism for the treatment of neurodegeneration, including Alzheimer's and Parkinson's diseases. We previously reported radiolabeling of a Food and Drug Administration-appr

Externí odkaz: https://doaj.org/article/725b84346084474882a75638559914f5

Synthesis and Evaluation of [11C]MCC950 for Imaging NLRP3-Mediated Inflammation in Atherosclerosis

Autor: Uzair S. Ismailani, Ariel Buchler, Nicole MacMullin, Faduma Abdirahman, Myriam Adi, Benjamin H. Rotstein

Publikováno v: Molecular Pharmaceutics. 20:1709-1716

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::203af362d9f2459125fd597d13581c85
https://doi.org/10.1021/acs.molpharmaceut.2c00915

The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication

Autor: Hossein Davarinejad, Yi-Chun Huang, Benoit Mermaz, Chantal LeBlanc, Axel Poulet, Geoffrey Thomson, Valentin Joly, Marcelo Muñoz, Alexis Arvanitis-Vigneault, Devisree Valsakumar, Gonzalo Villarino, Alex Ross, Benjamin H. Rotstein, Emilio I. Alarcon, Joseph S. Brunzelle, Philipp Voigt, Jie Dong, Jean-François Couture, Yannick Jacob

Publikováno v: Science
Davarinejad, H, Huang, Y-C, Mermaz, B, Leblanc, C, Poulet, A, Thomson, G, Joly, V, Muñoz, M, Arvanitis-Vigneault, A, Valsakumar, D, Villarino, G, Ross, A, Rotstein, B H, Alarcon, E I, Brunzelle, J S, Voigt, P, Dong, J, Couture, J-F & Jacob, Y 2022, ' The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication ', Science, vol. 375, no. 6586, pp. 1281-1286 . https://doi.org/10.1126/science.abm5320

The tail of replication-dependent histone H3.1 varies from that of replication-independent H3.3 at the amino acid located at position 31 in plants and animals, but no function has been assigned to this residue to demonstrate a unique and conserved ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9ac8d5b667a21faac2d0bd5e313c09
https://doi.org/10.1126/science.abm5320

More than a ligand: PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I interferon pathway

Autor: Jonathan J. Hodgins, John Abou-Hamad, Ash Hagerman, Edward Yakubovich, Christiano Tanese de Souza, Marie Marotel, Ariel Buchler, Saleh Fadel, Maria M. Park, Claire Fong-McMaster, Mathieu F. Crupi, John C. Bell, Mary-Ellen Harper, Benjamin H. Rotstein, Rebecca C. Auer, Barbara C. Vanderhyden, Luc A. Sabourin, Marie-Claude Bourgeois-Daigneault, David P. Cook, Michele Ardolino

Targeting the PD-1/PD-L1 axis has transformed the field of immune-oncology. While conventional wisdom initially postulated that PD-L1 serves as the inert ligand for PD-1, an emerging body of literature suggests that PD-L1 has cell-intrinsic functions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1a75c947049681a8f0fcf1c901c4543
https://doi.org/10.1101/2022.08.31.506095